Sentences with phrase «developing drug design»

Imagine developing a drug designed to inhibit a protein that helps cancer cells proliferate and survive only to find that the drug does not perform very well in the clinic.

Not exact matches

Drugs that were effective at warding off infections decades ago are now less potent because the bacteria they were designed to kill have developed defence mechanisms.

Elion and Hitchings developed a method known as «rational drug design» that helped revolutionize drug making.

Rõivas, the former Prime Minister, says Estonia is working on developing «precision medicine» that would tap into the genome data of its 1.3 million citizens in order to better diagnose illnesses, treat people, and design personalized drugs.

What Boger wants is to create a better way to develop drugs: through a process called structure - based design in which scientists build up a new drug, atom by atom, after determining the type of molecule that might interrupt the disease process.

Many of the candidate drugs developed in recent years were designed to clear these protein aggregates.

The research team currently is working to identify new biomarkers that will allow them to develop a better understanding of how drug resistance develops, and how to best design effective combinations of medications that may improve patient responses.

Dr. Melnick developed the first BCL6 inhibitors nine years ago, and has continued to improve upon the design of these drugs so they could be used to treat cancer patients.

«Understanding how drug resistance develops can help in the design of new agents or strategies to overcome resistance,» says principal investigator Sameek Roychowdhury, MD, PhD, assistant professor of medicine and of pharmacology in the Division of Medical Oncology at the OSUCCC — James.

«The challenge has been how to direct certain therapies designed to manipulate genes of interest in specific cells without developing a specific drug carrier for each specific cell type.

«We're doing a lot of work to improve clinical trial design and to improve the way drugs are discovered and developed,» Perlmutter says.

Researchers at the San Diego Supercomputer Center at the University of California, San Diego, have developed software that greatly expands the types of multi-scale QM / MM (mixed quantum and molecular mechanical) simulations of complex chemical systems that scientists can use to design new drugs, better chemicals, or improved enzymes for biofuels production.

These so - called artemisinin combination therapies (ACTs)-- there are six combinations — are designed to stave off resistance, in much the same way that combinations curb HIV's ability to develop resistance to any single drug.

Drugs designed to selectively block activated BRAF have led to significant improvement in clinical response and overall survival in melanoma patients, but resistance to these drugs often develops — leading to recurrDrugs designed to selectively block activated BRAF have led to significant improvement in clinical response and overall survival in melanoma patients, but resistance to these drugs often develops — leading to recurrdrugs often develops — leading to recurrence.

The drug candidates it has developed are designed for single pathogens, not multiple threats.

Scientists have developed a three - in - one blood test that could transform treatment of advanced prostate cancer through use of precision drugs designed to target mutations in the BRCA genes.

When Theravance, the company in South San Francisco, California, that developed the drug, designed the large phase III clinical trials needed for approval, the FDA simply required a demonstration that the drug eliminated symptoms of infection as reliably as the approved antibiotic vancomycin.

We refer to these as «alerts»: they can be used by drug design experts to try to avoid certain interactions and / or structures in order to develop safer drugs,» says Aloy.

«Now, because we know the resistance mechanism, we can design elements to minimize the emergence of resistance as these promising new drug candidates are developed,» said Ben Shen, a TSRI professor who led the study, which was published February 20, 2014 online ahead of print by the Cell Press journal Chemistry & Biology.

Professor Michael Lisanti, who designed the study, explained: «We now know that a proportion of cancer cells escape chemotherapy and develop drug resistance; we established this new strategy to find out how they do it.

This knowledge may be used to develop new ways for opening the blood - brain - barrier to increase the efficacy of the brain cancer drugs and for the design of treatment regimes that strengthens the integrity of the blood - brain barrier.»

Anderson and Valerie Grum - Tokars, a junior structural biologist on the team, developed a three - dimensional structure of human p38 MAPK, enabling the chemists to design and synthesize novel drug - like small molecules that would disable it.

Prof. Joost Schymkowitz and Prof. Frederic Rousseau of VIB - KU Leuven in collaboration with Prof. Johan Van Eldere of University Hospitals Leuven have gone one step further: they have developed a new way of designing antibiotic drugs that can give rise to many new antibacterial molecules.

Until now, agents that inhibit Pin1 have been developed mainly through rational drug design.

Inspired by the earlier work, Deborah Fuller from the University of Washington in Seattle, USA, who is interested in developing influenza drugs and vaccines, teamed up with David Baker, also at the University of Washington, who is an expert in computational protein design.

Janssen GPH will also prioritise work with the International Partnership for Microbicides developing the investigational drug dapivirine for use as a monthly vaginal microbicidal ring designed to prevent sexual transmission of HIV and continue its pact with Drugs for Neglected Diseases initiative for the preclinical research of a reformulated form of flubendazole for lymphatic filariasis (elephantiasis) and onchocerciasis (river blindness), Janssen GPH is also developing a new, chewable formulation of Vermox (mebendazole) that will facilitate treatment of intestinal worms in younger children.

-- Drug design: we develop new virtual screening and chemoinformatics methods.

WASHINGTON, DC — May 16, 2010 — At a time when the cost of developing a new drug is skyrocketing and research money is tight, it is important to be creative in designing new therapies for rare diseases and bringing them to market, according to speakers at the eighth Annual Meeting of the American Society for -LSB-...]

Candix AB, in cooperation with Nanexa AB, develops Nanocontainers for drug delivery using a proprietary nanotechnology platform that enables flexible design to optimize performance properties.

Our Drug Design Studio is a proprietary digital tool developed by our in - house software engineering team.

I got a new laboratory of research in bioinformatics and computational chemistry, in which we develop mostly studies in drug design and in silico evaluation of environmental pollutants, and I also proposed a new master program in Bioinformatics.

To address this growing problem, NIAID is funding and conducting research on many aspects of antimicrobial (drug) resistance, including basic research on how microbes develop resistance, development of new and faster diagnostics, and clinical trials designed to find new vaccines and treatments effective against drug - resistant microbes.

Swedish researchers are developing a new drug designed to curb alcoholism.

Panne's findings led to a side project on structure - based drug design with industry partners to develop novel drugs.

A bioengineer in the College of Engineering and Computer Science at Florida Atlantic University has received a $ 141,743 grant from the National Cancer Institute of the National Institutes of Health to develop a novel biodegradable polymer stent that will be designed to prevent complications while at the same time serving as a drug delivery system for esophageal cancer therapy.

Drug from Mediterranean Weed Kills Tumor Cells Scientists at the Johns Hopkins Kimmel Cancer Center, working with Danish researchers, have developed a novel anticancer drug designed to travel — undetected by normal cells — through the bloodstream until activated by specific cancer proteDrug from Mediterranean Weed Kills Tumor Cells Scientists at the Johns Hopkins Kimmel Cancer Center, working with Danish researchers, have developed a novel anticancer drug designed to travel — undetected by normal cells — through the bloodstream until activated by specific cancer protedrug designed to travel — undetected by normal cells — through the bloodstream until activated by specific cancer proteins.

Other companies, including the Swiss drug giants Novartis and Roche, along with Boston's Paratek Pharmaceuticals, are developing ingestible small - molecule drugs designed to increase the inclusion of SMN2 «s exon 7.

Rational drug design develops fewer compounds compared to high - throughput screening.

Further the Meiler laboratory develops a structure - based drug design module for ROSETTA and docking protocols particularly suited for docking small molecules into comparative models.

CancerNetwork speaks with Patricia S. Steeg, PhD, who has recently written a perspective in the journal Nature calling for a shift in both the types of drugs that are developed for breast cancer and in the way clinical trials are designed and executed.

We have designed and developed a data integration and visualization platform that provides evidence about the association of known and potential drug targets with diseases.

The space was also designed with the public in mind, featuring interactive tour stops throughout the lab space that use technology to underscore IDRI's work in developing vaccines, drugs and diagnostics, as well as large built - in windows to showcase IDRI's specialized facilities, including manufacturing.

That's why I have been working with my editorial team to develop a series of comprehensive, yet easy - to - read health books and free special reports designed to give you the tools you need to take control of your health the natural way, without dangerous pharmaceutical drugs.

Children as young as 18 months are now receiving antipsychotic drugs, despite the fact that the diseases they're designed to treat rarely develop before adolescence.

For example, the difference between investigating the chemical properties of a new compound versus designing a marketable drug, or in education, between funding research in neuroscience versus developing that research into instructional resources).

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The Pharmacy Services segment operates retail and mail order pharmacies, and specialty pharmacies for individuals that require complex drug therapies; designs and administers pharmacy benefit plans for its clients (including Medicare Part D services); and develops and operates Pharmacy Services information systems.

1) Equitable drug design: The BRF is committed to developing new therapies, especially designed to treat cancer in pets but also to benefit people as well.

Drug companies have developed a large number of NSAIDs designed especially for dogs.

Because of advances in drug design and precision medicine, researchers have been able to target certain molecules within a cell at the root of a particular disease and to develop specific therapies...