Not exact matches
«Current cancer treatment often focuses on targeting cancer cells, but is not focused on targeting the
fibrotic connective tissue, that may
develop first, before you have cancer.
Dr. Summer and colleagues are currently working to
develop a therapy that could restore lipid production in the lungs of pulmonary fibrosis patients and slow the
fibrotic process.
Fibrotic diseases, such as chronic kidney disease and failure, lung disease, heart failure and cirrhosis of the liver, are estimated to be responsible for up to 45 percent of deaths in the
developed world.
NorthSea Therapeutics
develops therapeutics for NASH and other metabolic, inflammatory and
fibrotic diseases.
In recent years, researchers have
developed so - called «senolytic» drugs that wipe out senescent cells in aging mice and mouse models of age - related disease, exploiting the high dependence of these cells on specific biochemical survival pathways.9, 10 In these studies, senolytic drugs have restored exercise capacity9 and formation of new blood and immune precursor cells11 in aging mice to near youthful norms, and prevented or treated mouse models of diseases of aging like osteoarthritis, 12
fibrotic lung disease, 13 hair loss, 14 atherosclerosis, 15,16 and age - related diseases of the heart itself.9 UNITY Biotechnology is leading a growing charge toward the clinic, with human clinical trials expected to begin in 2019.