Sentences with phrase «developing lead compounds»

We are pursuing both goals by studying the underlying biology, defining therapeutic targets, identifying active molecules by high - throughput screening and developing lead compounds.

Not exact matches

The purple range, which comes just one week after leading cocoa processor Barry Callebaut announced it has developed pink chocolate, derived naturally by isolating specific compounds in cocoa beans.

To try to develop a more sensitive probe for isolating individual peptides — short strands of amino acids — from a pool of similar molecules, a team led by chemist Clark Still of Columbia University 4 years ago synthesized small organic compounds that selectively fish out peptides dissolved in chloroform.

The drug - like compounds can be modified and developed into medicines that target a protein in the human body that is responsible for chemotherapy resistance in cancers, said biochemist Pia D. Vogel, lead author on the scientific paper reporting the discovery.

Although the process of developing the new compounds into clinical drugs is complex and lengthy, Professor Kirk is optimistic the findings will lead to new treatments.

A team led by Professor Oganov developed the world's most universal and powerful algorithm for crystal structure and compound prediction — USPEX (Universal Structure Predictor: Evolutionary Xtallography).

«Through our collaboration with DiscoverX, we screened a large set of compounds that we call Published Kinase Inhibitor Set 2, and these results allowed us to reach the halfway point in constructing the KCGS» said David Drewry, a research associate professor at the UNC Eshelman School of Pharmacy and SGC - UNC principal investigator who is leading the project to develop the Kinase Chemogenomic Set.

In the new study, led by Purdue biochemist Natalia Dudareva, the team looked for genetic changes as the plant developed from its budding stage, which had the lowest levels of volatile organic compounds, to its flower - opening stage, with the highest levels.

After a project lasting anywhere from 2 months to 2 years, the lead compounds he has made are passed on to the company's Optimisation Team, which works them up to the stage at which they can be developed into products.

«These findings should lead to the rational design of R - ATAs based on this structural information to develop novel biocatalysts useful for the production of a diverse range of chiral amine compounds.

The initial work identified the precursor to GS - 5734, a small - molecule antiviral agent, which led to the effort by Gilead and USAMRIID to further refine, develop and evaluate the compound.

Next we use such assays to identify LEAD chemical compound (s) with therapeutic potential for HD or to validate drug or gene - based therapeutic approaches developed by our collaborators (Pr.

«This is another example of how our gene discovery work has led us to targets against which promising compounds have been developed by others in other indications.

Navire Pharma's lead compounds were discovered and developed by the IACS team led by Phil Jones, Ph.D., executive director and head of drug discovery at IACS, together with Benjamin G. Neel, M.D., Ph.D., director of the Laura and Isaac Perlmutter Cancer Center at New York University (NYU).

The company is based around novel compounds, including NAV - 847, discovered and developed by the cross-functional drug discovery team within IACS led by Philip Jones, Ph.D., executive director and head of drug discovery at IACS.

Its lead therapeutic programs, which leverage the company's expertise in chemistry and structural biology, include DG041, an antiplatelet compound being developed for the prevention of arterial thrombosis; DG051 and DG031, compounds targeting the leukotriene pathway for the prevention of heart attack; and DG071 and a platform for other PDE4 modulators with therapeutic applications in Alzheimer's disease and other conditions.

After developing and optimizing assays in - house, Gladstone scientists can transfer these assays to the SMDC or other external facilities to perform high - throughput screening with large compound libraries to identify potential drugs that may lead to therapies.

Reykjavik, ICELAND, May 10, 2005 — deCODE genetics (Nasdaq: DCGN) today announced the publication of a landmark article by a team of its scientists presenting the results of Phase II clinical studies of DG031, the company's lead compound being developed for the...

Ongoing research could result in a better understanding of how nutrition affects immune function, and perhaps lead to developing therapeutically useful natural compounds which can boost the innate immune response.

Aside from the outdated and erroneous formulations, he has also developed an erroneous understanding of Kirchhoff's Law, which compounds his erroneous understanding and formulation of his greenhouse effect parameterizations — which inevitably leads to his erroneous global warming and greenhouse effect conclusions.

Recalling the concern reflected in the outcome document of the United Nations Conference on Sustainable Development, entitled «The future we want», 1 that the health of oceans and marine biodiversity are negatively affected by marine pollution, including marine debris, especially plastic, persistent organic pollutants, heavy metals and nitrogen - based compounds, from numerous marine and land - based sources, and the commitment to take action to significantly reduce the incidence and impacts of such pollution on marine ecosystems, Noting the international action being taken to promote the sound management of chemicals throughout their life cycle and waste in ways that lead to the prevention and minimization of significant adverse effects on human health and the environment, Recalling the Manila Declaration on Furthering the Implementation of the Global Programme of Action for the Protection of the Marine Environment from Land - based Activities adopted by the Third Intergovernmental Review Meeting on the Implementation of the Global Programme of Action for the Protection of the Marine Environment from Land - based Activities, which highlighted the relevance of the Honolulu Strategy and the Honolulu Commitment and recommended the establishment of a global partnership on marine litter, Taking note of the decisions adopted by the eleventh Conference of the Parties to the Convention on Biological Diversity on addressing the impacts of marine debris on marine and coastal biodiversity, Recalling that the General Assembly declared 2014 the International Year of Small Island Developing States and that such States have identified waste management among their priorities for action, Noting with concern the serious impact which marine litter, including plastics stemming from land and sea - based sources, can have on the marine environment, marine ecosystem services, marine natural resources, fisheries, tourism and the economy, as well as the potential risks to human health; 1.