Timed with the hundredth anniversary of their discovery, a new review published in the British Journal of Pharmacology examines the challenges and opportunities of
developing phages as health - promoting, commercially - viable biopharmaceuticals.
Their goal is to
develop a phage cocktail that works reliably when fed to livestock.
Not exact matches
It's
developing a machine - learning algorithm that uses data from the genomes of both
phages and bacteria.
And thats one reason that we use a cocktail of different ones, she says — because its unlikely the bugs will quickly
develop resistance to more than one
phage.
Ganz said that she hoped the publication of the
phage's sequence information would enable other researchers to investigate further and potentially
develop applications for the
phage and its proteins.
Scientists at the Universitat Autònoma de Barcelona (UAB) and the Catalan Institute for Nanoscience and Nanotechnology (ICN2) have
developed a nanoencapsulation system with a liposome coating in order to increase the efficacy of bacteriophages in oral
phage therapy.
To overcome these limitations, researchers
developed a nanoencapsulation system using liposome capsules and applied them to the three aforementioned virulent bacteriophages in order to compare the effects of liposome - encapsulated
phages and nonencapsulated
phages on the concentration of Salmonella in model broiler chickens experimentally contaminated with the bacteria.
The methodology
developed allows encapsulating bacteriophages of different sizes and morphologies, demonstrates the advantages of using encapsulated bacteriophages for oral
phage therapy and, moreover, the nanometric size allows adding it to potable water and fodder.
The technology
developed could be applied to bacteriophages with different morphologies to be used in
phage therapy, in both animals and humans.
And even if there were any, for example due to a bacterium changing its surface structures to prevent the virus from attaching, the new technology makes it possible to
develop a suitable
phage against which a bacterium has not yet
developed resistance.
Young and his research team at the Center for
Phage Technology, jointly sponsored by Texas A&M AgriLife Research and Texas A&M University, have not only developed better understanding of phage, but also bacteria in gen
Phage Technology, jointly sponsored by Texas A&M AgriLife Research and Texas A&M University, have not only
developed better understanding of
phage, but also bacteria in gen
phage, but also bacteria in general.