What I am interested is whether medication could reduce the risk of
developing psychiatric diseases.
Still, looking at someone's genome alone will probably never be enough to determine if they'll go on to
develop a psychiatric disease — other factors, including environmental factors like severe stress, play a strong role too.
Not exact matches
«While many patients with Anti-NMDAR Encephalitis present with isolated
psychiatric symptoms, most of these patients subsequently
develop, in a matter of days, additional neurological symptoms which help to make the diagnosis of the
disease.
The new finding is the latest evidence supporting a growing precision medicine model of
psychiatric disease in which disruptions of certain genes during brain development contribute to a person's risk for multiple
psychiatric disorders, with other genetic or epigenetic drivers, random developmental events, or environmental influences determining the specific
disease an individual
develops, said senior author Benjamin Cheyette, MD, PhD, an associate professor of psychiatry and a member of the UCSF Weill Institute for Neurosciences and the Kavli Institute for Fundamental Neuroscience at UCSF.
«Identifying gene variants that are general risk factors for neurological and
psychiatric disease is important, but understanding exactly which cell types in the
developing brain are compromised and what the consequences are is still extremely challenging,» Pollen added.
The findings also suggest that identifying the brain circuits affected by mutated genes linked to
psychiatric disease could help scientists
develop more personalized treatments for patients in the future, Feng says.
«Although our goal is to
develop systems that can treat infectious
diseases such as malaria, HIV or tuberculosis in sub-Saharan Africa or Southeast Asia, there are many applications here in the U.S. for treating chronic conditions such as heart
disease, diabetes or
psychiatric illness.
Xin Jin's team charts the fundamental principles of how the brain learns and generates actions to
develop cures for a wide range of related neurological and
psychiatric diseases.
Within the fields of microbiology and immunology, neurologic
diseases, neuropharmacology, behavioral, cognitive and developmental neuroscience, and
psychiatric disorders, the center's research programs are seeking ways to:
develop vaccines for infectious and noninfectious
diseases; understand the basic neurobiology and genetics of social behavior and
develop new treatment strategies for improving social functioning in social disorders such as autism; interpret brain activity through imaging; increase understanding of progressive illnesses such as Alzheimer's and Parkinson's
diseases; unlock the secrets of memory; treat drug addiction; determine how the interaction between genetics and society shape who we are; and advance knowledge about the evolutionary links between biology and behavior.
One of Zhang's long - term goals is to use genome - editing technologies to better understand the nervous system and
develop new approaches to the treatment of
psychiatric disease.
Increased understanding of the
developing brain and how deviations from normal development can increase the risk of neurological and
psychiatric diseases has created a rich landscape of opportunity for collaborations between leading academic medical centers and pharmaceutical and biotechnology companies dedicated to identifying new drugs and other interventions to help children.
Prime objectives in studying neurologic and
psychiatric disorders are to
develop discriminating markers and generate data that can provide insight into
disease pathogenesis.