By invigorating the mitochondria, SIRT3 and SIRT4 extend the life of cells, by preventing flagging mitochondria from
developing tiny holes (or pores) in their membranes that allow proteins that trigger apoptosis, or cell death, to seep out into the rest of the cell.
When the gut wall
develops tiny holes in it, it's as if the bouncer has left the door unattended, allowing all the bad guys to flood in and cause a ruckus.
Not exact matches
Yes, they came super clean, however, a few washings later, they started
developing tiny little
holes which
developed into large
holes.
Researchers, including Karnik's group, have
developed techniques to fabricate graphene membranes and precisely riddle them with
tiny holes, or nanopores, the size of which can be tailored to filter out specific molecules.
Or (in dentistry) a
tiny hole in a tooth that
develops over time.
Using a technique they
developed last year, the researchers then etched
tiny, uniform
holes in graphene — small enough to let water molecules through, but not larger contaminants.
The tight junctions which regulate the passage of substances weaken, and
tiny holes develop in the membrane itself.
I find their tees very expensive and still eventually
develop those
tiny annoying
holes.