Sentences with phrase «developing zebrafish»

Marija Matejčić: Coordination of tissue shape and size in the developing zebrafish neuroepithelium

Developing zebrafish methodology to model genetic and environmental modifiers of the vertebrate stress response system (SRS).

Developing zebrafish models of complex phenotypes relevant to human brain disorders.

Emergence of Patterned Activity in the Developing Zebrafish Spinal Cord.

Functional validation of the human mutation was done in developing zebrafish.

COURTESY SHENDURE AND SCHIER LABS CRISPR FOR FATE - MAPPING Researcher: Jay Shendure, Professor, Department of Genome Sciences, University of Washington Project: In collaboration with Alexander Schier's lab at Harvard University, Shendure's group came up with a new way to trace cell lineages in cell culture and in whole organisms — in this case, developing zebrafish.

Study results published online in the journal Green Chemistry show that the molecules, which are aimed at removing hazardous endocrine disruptors from water sources, aren't endocrine disruptors themselves as they proved to be non-toxic to developing zebrafish embryos.

This is a developing zebrafish skeleton showing Sox9 activates a green fluorescent protein reporter in chondrocytes.

In the initial stages of the research project, Yaniv's team members Julian Nicenboim and Dr. Guy Malkinson obtained images of developing zebrafish embryos, whose transparent bodies make it possible to document embryonic development in real time over several days.

COVER A three - dimensional micrograph of computationally separated cells with their internal organelles, as captured by a movie of the developing zebrafish eye.

They found that the TAML - treated BPA water did not show estrogen activity or cause abnormalities in yeast and developing zebrafish embryos.

Tobin, who helped to develop the zebrafish as a model of TB, decided to use the system to study the blood vessels associated with granulomas.

Not exact matches

In 2010, Yanik's team developed a technology for rapidly moving zebrafish larvae to an imaging platform, orienting them correctly, and imaging them.

The study found that zebrafish that failed to inherit specific genetic instructions from mom developed fatal defects earlier in development, even if the fish could make their own version of the gene.

It is, however, clear that cocaine is taken up rapidly and continuously by zebrafish larvae, which at this early stage have not yet a fully developed blood - brain barrier.

«Zebrafish could have a unique niche [in cancer treatment],» says Leonard Zon of Harvard Medical School in Boston, who has used the fish for more than a decade to study how cancer develops.

Companies in the region that have announced staff cuts include Oxford - based Summit Corporation, a zebrafish genomics specialist; Alizyme of Cambridge, which is developing treatments for gastrointestinal diseases; and Silence Therapeutics of London, an siRNA company.

Having spent his first 5 years in that position establishing his own research theme and tools to study zebrafish development, «now it is thanks to this programme that I can expand and fully develop it.»

To test whether fatty acid levels in the bloodstream was a cause or a consequence of disease, the researchers turned to a zebrafish model of Crohn's disease that had been developed by Stefan Oehlers, a post-doctoral fellow in David Tobin's group at Duke.

They developed a streamlined and fast, though inexpensive, method that allows direct access to a pure and vital population of zebrafish OPCs in less than 2 hours.

The Weinstein lab studies zebrafish to understand how the blood and lymphatic systems develop.

When the scientists prevented the genes from working in zebrafish, they failed to develop fingerlike projections called fin rays — the fishes» «hands.»

We will continue to use the zebrafish to develop transgenic models.

Using zebrafish, they developed the first animal model for the oligoneural subtype of CNS - PNET.

First, the researchers developed a model of Parkinson's in zebrafish — the first such animal model of the disease — and exposed them to ziram so that they lost dopamine.

Next, the researchers gave the non-protected zebrafish an investigational drug, CLRO1, being developed by UCLA scientists that breaks up the protein aggregates, or clumps, in Parkinson's patients.

Vitargent has also developed a dioxin test on zebrafish (Danio rerio).

Previous studies have found that mouse and zebrafish embryos do not develop properly in simulated microgravity.

During the course, students collect zebrafish embryos and watch them develop from single cells to swimming larvae complete with beating hearts and distinct pigmentation.

Cardiac Edema and Cranial Injuries Laboratory experiments involving zebrafish have previously shown that oil pollution causes the larvae to develop cardiac edema.

Recent studies on species such as zebrafish showed scales and teeth developing from distinctly different clusters of cells in fish embryos, pouring cold water on «teeth from scales» theories.

As a zebrafish develops, a mass of cells moves along the developing animal's side.

Specifically, they tested new drugs in zebrafish, a small, tropical fish genetically similar to humans, whose brains can develop seizures in a manner similar to patients with epilepsy.

Durdu, a PhD student in Darren Gilmour's lab at EMBL, found this behaviour in specific groups of cells in the zebrafish: the cells that will develop into the animal's «lateral line», a series of ear - like organs along the fish's flank that allow it to sense changes in water pressure.

Drawing upon the cell culture expertise of Noriyoshi Sakai, Ph.D., and Kayoko Kurita, of Fukui Prefectural University, the Japanese - U.S. team developed a system that enables immature sperm cells, or spermatagonia, taken from male zebrafish to survive long enough in vitro that they can receive foreign genes inserted by a retrovirus.

Rieger used zebrafish larvae to model peripheral neuropathy because the embryos develop rapidly and because the larval fish are translucent, making them ideal for studying the progression of nerve degeneration in live animals.

By the third day, all of its major organs have fully developed and moved into proper position, offering scientists a view of what has been referred to as the zebrafish's «artful etchings.»

Researchers have discovered a gene in zebrafish so powerful it can be used to redirect the fate of cells in the developing embryo to become beating heart cells, suggesting that a similar gene in humans could be used to generate heart cells in culture for transplant in ailing people.

Developing innovative zebrafish models for drug abuse research.

Dr. Yin is seeking to understand how zebrafish regenerate damaged tissue so that therapies can be developed to reawaken our dormant genetic codes for regeneration.

On this website you can learn about how zebrafish can help us understand human diseases and how to develop treatments for them.

Studies with Zebrafish embryos help scientists understand how whole organisms develop from the single - celled embryo.

Like the frog, zebrafish embryos develop externally and can be viewed and manipulated at all stages.

Enriched by the rapid evolution of these technologies, TEFOR - TACGene has developed a solid expertise in the design, production and use of TALE - N and CRISPR / Cas9 systems, both for its own research projects in cultured cells and in collaboration, in many model organisms, including the rat, zebrafish, Drosophila, and Xenopus as part of the National Infrastructure in Biology and Health TEFOR supported by Investissement d'Avenir programme (2012 - 2019).

TEFOR - AMAGEN has developed two models of teleost fishes: medaka (Oryzias latipes) and zebrafish (Danio rerio).

This could be because coho take longer than zebrafish to develop, making their embryos more sensitive to trace amounts of toxic substances.

Zebrafish larvae exposed to runoff from a June 2014 storm developed one - third fewer hair cells in their head and trunk.

Zebrafish rad51 loss - of - function mutants developed key features of FA, including hypocellular kidney marrow, sensitivity to cross-linking agents, and decreased size.

In a report published on September 30 in Nature Genetics, Katsanis and his team used a small transparent fish, zebrafish, to literally watch what happened if they chemically blocked the production of three proteins that are required for primary cilia function during the period when a fish egg develops into a grown up, fully - finned fish.

Researchers have developed powerful new techniques to see in unprecedented detail how blood - forming cells develop in zebrafish.