Sentences with phrase «development of a number of diseases»

Not exact matches

The company is also seeking deeper inroads into rare diseases, with a number of assets in late - stage development, and last year it scored a major regulatory win when Europe approved its «bubble boy syndrome» gene therapy Strimvelis.

Epidemiologic research shows that human milk and breastfeeding of infants provide advantages with regard to general health, growth, and development, while significantly decreasing risk for a large number of acute and chronic diseases.

Research in the United States, Canada, Europe, and other developed countries, among predominantly middle - class populations, provides strong evidence that human milk feeding decreases the incidence and / or severity of diarrhea,1 - 5 lower respiratory infection,6 - 9 otitis media,3,10 - 14bacteremia, 15,16 bacterial meningitis, 15,17 botulism, 18 urinary tract infection, 19 and necrotizing enterocolitis.20, 21 There are a number of studies that show a possible protective effect of human milk feeding against sudden infant death syndrome,22 - 24insulin - dependent diabetes mellitus,25 - 27 Crohn's disease, 28,29 ulcerative colitis, 29 lymphoma, 30,31 allergic diseases,32 - 34 and other chronic digestive diseases.35 - 37 Breastfeeding has also been related to possible enhancement of cognitive development.38, 39

Breastfeeding is an unequalled way of providing ideal food for the healthy growth and development of infants1, providing protection from morbidity and mortality due to infectious diseases2 and chronic diseases later in life.3 Exclusive breastfeeding is recommended, starting within one hour of birth and for the first 6 months of life, with continued breastfeeding to 2 years of age and beyond.4 However, rates of initiation, exclusive breastfeeding and breastfeeding duration have fallen since the widespread introduction and promotion of breast - milk substitutes.5 Successful breastfeeding depends on a number of factors, including a re-normalisation of breastfeeding as the infant feeding method of choice through antenatal counselling and education and breastfeeding support to prevent and resolve breastfeeding difficulties.

A U.K. study found a surprising five and a half times, or 550 %, the number of eventual IBD (irritable bowel disease) developments after antibiotic exposure before the age of one, versus no antibiotic exposure in childhood.

Newborn Screen / Metabolic Panel: A blood test done by a small prick to the heel, this test checks baby for a number of potential diseases and disorders that require fast treatment to ensure normal development.

The United Nations has attempted to fill this gap by securing a pledge from developed countries to halve the number of people without any form of sanitation — whether basic outdoor latrines or indoor toilets — by 2015 as part of its Millennium Development Goals (a series of goals for world development, ranging from alleviating poverty to fighting diseases Development Goals (a series of goals for world development, ranging from alleviating poverty to fighting diseases development, ranging from alleviating poverty to fighting diseases like AIDS).

Mardinoglu says the team's network modeling approach, which relied on data from the Sweden - based Human Protein Atlas project and The Genotype - Tissue Expression (GTEx) project consortia, can be used in the identification of drug targets and eventually in the development of efficient strategies for treating a number of chronic liver diseases.

Differences in the ability of a particular gene to influence a child's development depending on who it was inherited from, have been seen in a number of disorders, including Huntington's disease and fragile - X syndrome («Why genes have a gender», New Scientist, 22 May 1993).

One concern is the development of multiple sclerosis, which has been fuelled by social and news media reports of cases occurring after HPV vaccination, and an increasing number of case reports published in the medical literature describing vaccine recipients who developed multiple sclerosis as well as other demyelinating diseases.

Early identification of patients with risk factors for a number of disorders would allow for early treatment that could potentially stop the development of disease in its earliest stages.

The Basque Institute for Agricultural Research and Development, Neiker - Tecnalia, has created four new potato clones which are characterised by their high antioxidant content, their good production both in size and number of tubers, as well as by their resistance to the usual diseases of this crop.

Large numbers of these pileups and double - strand breaks are lethal to the cell, serving as a jumping off point for the development of disease.

A number of studies have shown that miRNAs are critical for normal development and cellular growth and may contribute to the complexity of neurodegenerative diseases.

Raydiance's technology has attracted the attention of the U.S. Food and Drug Administration (FDA), which in July 2007 signed the company to a two - year cooperative research and development agreement that has allowed the FDA's Center for Devices and Radiological Health (CDRH) to evaluate the use, safety and effectiveness of Raydiance's USP laser system in a number of areas, including the ablation of corneal tissues in refractive surgery and corneal repair; the administration of light therapy for treating cancer, cardiovascular disease and diabetes; and the removal of plaque on teeth without damaging the enamel.

«Even so,» the authors add, «cutting - edge gene therapy - based strategies in reconstructive procedures [are close] to setting valuable milestones for development of efficient treatments in a growing number of local diseases and injuries.»

«We were able to observe that a number of epigenetic changes had already taken place in healthy subjects as a result of age or high BMI, and were therefore able to conclude that these changes could contribute to the development of the disease,» said Charlotte Ling.

The research, one of a number of studies to explore the connection between heart disease and development of depression by researchers at Intermountain Medical Center Heart Institute, will be published on July 28 in the European Heart Journal — Quality of Care & Clinical Outcomes.

The research department has a significant number of translational research programmes involving the development of infectious disease vaccines, therapeutics and diagnostics.

«Messenger RNA therapeutics ™ promises to vastly expand the number of diseases we can treat and usher in an entirely new era of drug discovery and development,» said Stéphane Bancel, president and founding CEO of Moderna.

They examined 17 cancer types in 69 countries and found a strong correlation between the number of stem - cell divisions and the incidence of the disease, regardless of the countries» environment or state of economic development.

It can be used in the identification of drug targets and eventually in the development of efficient strategies for treating a number of chronic liver diseases.

Research efforts within the branch advance the development of treatments for a number of diseases.

It's not just ocean acidification threatening these reefs, it's a number of factors including overfishing, disease, development and warming waters.

Now, a new vaccine under development could deal another blow to the disease, lowering the number of deaths even further by targeting dozens of additional strains of S. pneumoniae, and anticipating future versions of the bacteria responsible for pneumococcal disease, which includes sepsis and meningitis.

There are a number of challenges inherent in the development of astrocyte - based treatments for human disease.

In a substudy, review outcomes were also compared across different types of clinical research, based in large part on the designations and definitions derived from a number of sources, including a report by Nathan, 14 the Institute of Medicine, 20 the NIH Director's Panel on Clinical Research, 9 the Association of American Medical Colleges and American Medical Association, 21 and the Agency for Healthcare Research and Quality.22 All 3599 R01 applications involving human subjects that were submitted to NIH for the October 2002 council were categorized into 1 of the following: (1) patient - oriented studies of mechanisms of human disease (bench to bedside); (2) clinical trials and other clinical interventions; (3) patient - oriented research focusing on development of new technologies; (4) epidemiological studies; (5) behavioral studies (including studies of normal human behavior); (6) health services research; and (7) use of deidentified human tissue.

The regulation of cell size and cell numbers is an important part of determining the size of organs in development, as well as of controlling cell over-proliferation in diseases such as cancer and diabetes.

This program has resulted in the discovery of unique variants in environmentally responsive genes, the development of a number of resources, and capacity building in the environmental epidemiology communities in order to incorporate gene - environment hypotheses and tools into human population - based studies on a number of environmentally relevant diseases.

Agrobusiness is the biggest cause of deforestation, CO2 emissions and animal extinction, besides of being responsible for the killing of more than a thousand innocent people, increase in the numbers of cancer and heart diseases, and the development of a culture of cruelty against animals.

«The chronic exposure to high levels of ROS is associated with the development and / or progression of pathophysiological processes, and implicated in an increasing number of human diseases, such as cardiovascular, metabolic, inflammatory and neurogenerative diseases, cancer as well as muscle atrophy and the ageing process.»

Impairment of the highly specific nutrient uptake processes, or compromised GI barrier function, as in «leaky gut syndrome,» can result from a number of causes including: • Low gastric acid production • Chronic maldigestion • Food allergen impact on bowel absorptive surfaces • Bacterial overgrowth or imbalances (dysbiosis) • Pathogenic bacteria, yeast or parasites and related toxic irritants • The use of NSAIDs and antibiotics Impairment of intestinal functions can contribute to the development of food allergies, systemic illnesses, autoimmune disease, and toxic overload from substances that are usually kept in the confines of the bowel for elimination.

These signs, which could be attributed to a number of causes, are very often poorly defined or not specific and are very often overlooked, particularly in the early stages of development / progression of the disease.

Less Diversity in Gut Bacteria Increases Obesity and Disease Risk: An international team of scientists have established links between the number of different bacterial species in the gastrointestinal tract and obesity, further weight gain, and the development of obesity - and inflammation - related diseases.

The resulting obesity predisposes cats to a number of medical conditions (BOX 5), as well as an increased risk for orthopedic disease.21 Excess weight also contributes to the development of musculoskeletal diseases and places excessive strain on joints, muscles, tendons, and ligaments, thus aggravating existing health problems.

This includes development of new therapies to help dogs that develop the disease today, as well as new methods for prevention and control that will reduce the number of dogs that will develop hemangiosarcoma in the future.

The development of the breeds has been associated with the increasing prevalence of a large number of genetic diseases [13].

In shelters, large numbers of animals share common sources of air, food, water, living space and caretaker attention, increasing stress and facilitating disease transmission and the development of behavior problems.

Players should look forward to a number of masteries currently in development, including Drain Essence, Raise Skeletons, Necrotic Edge, plus skill that help you «shatter the souls of your enemies to conjure violent wraiths,» «bolster your minions with necrotic powers, «fill the battlefield with disease and rot,» and generate «cruel new ways to dispose of your pathetic enemies.»

Healthy child development is the foundation for human capital and the basis for future community and economic development.1 A significant body of convergent research emphasises the importance of the prenatal and early years for health and developmental outcomes throughout the life course.2 For a growing number of children, suboptimal developmental trajectories are well established by the time they start school, and become increasingly difficult and costly to modify with the passage of time.3 Thus, investing in young children is important for the prevention of disease later in life and contributes to their full participation in society as healthy and productive adults.4, 5