«Our findings support the hypothesis that L1 retroelements, perhaps along with other virus - derived genomic elements, may contribute to
the development of autoimmune disorders characterized by high levels of type 1 interferon,» she said.
Not exact matches
Founded in 2011, Innovent has built a portfolio
of 16 potential products for treating cancer,
autoimmune disorders and other diseases, and seven
of those are in clinical
development.
Beckmann's work identifying TNFRs was critical to the
development of Enbrel, today prescribed to treat
autoimmune disorders such as rheumatoid arthritis and psoriasis.
Means notes that identifying the potential role
of TREML4 in human lupus may lead to the
development of drugs that could prevent or reduce the
development or progression
of lupus and another
autoimmune disorder called Sjögren's syndrome, which also appears to involve TLR7 overactivation.
The researchers are now looking at how ICOS signals can be altered to diminish
autoimmune disorders and augmented for more effective vaccine
development, and are beginning research on how ICOS signaling may benefit Chimeric Antigen Receptor - T cell (CAR - T) therapies, which involves engineering
of patient's own immune cells to recognize and attack their cancers.
«Icebreaker» protein opens genome for T - cell
development, researchers find: Study provides new view
of immune cell identity, which can be harnessed to fight cancer,
autoimmune disorders, and infectious diseases.»
Understanding celiac disease may speed the
development of new therapies for these
autoimmune disorders.
Today, «humanized» mice are in wide use in scientific research, promising hope for the
development of vaccines for HIV, multiple sclerosis, and other
autoimmune disorders.
Despite its potential broad applications, clinical
development of Hu5c8, a monoclonal antibody intended for treatment
of autoimmune disorders, was terminated due to unexpected thrombotic and cardiovascular events in patients.
She joined the Pillai lab as a post-doctoral research fellow in 2016 and continues to enjoy her work both treating patients with primary immunodeficiency in the clinic and studying the bridging gap between human primary immunodeficiency
disorders and the
development of autoimmune disease pathology in the lab.
Then, when they go gluten - free, since they are «gluten intolerant» as opposed to having celiac disease, it is unclear how closely they need to be followed for vitamin deficiencies, the
development of additional
autoimmune disorders, and other problems that are associated with long - standing celiac disease.
Thus, it can contribute to the
development of allergies and other
autoimmune disorders just the same as a gluten containing cereal such as wheat or spelt.
Over-consumption
of gluten has been linked to the
development of food intolerances, digestive issues including leaky gut, fatigue, weight imbalances, skin and mood
disorders and an increased risk for
autoimmune diseases.
It focuses on
development and commercializing therapies for the treatment
of cystic fibrosis; infectious diseases, including viral infections, such as influenza, and bacterial infections;
autoimmune diseases, such as rheumatoid arthritis; cancer, inflammatory bowel disease; and neurological
disorders, including pain, Huntington's disease and multiple sclerosis.
Evidence has emerged in recent years that over vaccination has been a major factor in the
development of both the epidemic increases in
autoimmune diseases, seizures, behavioral and hormonal
disorders, and cancer seen in younger and younger pets.