[38] A retrospective study of 90 patients with ALK - rearranged NSCLC metastatic to the brain found that OS after
the development of brain metastases was still prolonged at approximately 4 years (49.5 months), with patients frequently having multiple opportunities for salvage SRS at recurrence; 45 % of patients on follow - up had progressive brain metastases at death.
Researchers also examined the rates
of overall survival (OS),
development of distant
brain metastases (DBM), time to WBRT, and complications following SRS.