Sentences with phrase «development of cell populations»

Not exact matches

Prof. Jean - Christophe Marine (VIB - KU Leuven): «Unexpectedly, this ability to divide and contribute to melanoma development contrasted with the activities of other cell populations, such as melanocyte stem cells found in hair follicles, for instance.

They demonstrated that non-obese diabetic (NOD) mice treated with a specific (AID / RAD51) pathway inhibitor had larger populations of certain B cells that were capable of suppressing diabetogenic T cell responses, and greatly reduced T1D development, compared with untreated controls.

This allows us to reveal how drugs affect heart functions in a scenario where the two cell populations are closely coupled,» said Ben Maoz, Ph.D., a co-first author on the second study, who also is a Technology Development Fellow at the Wyss Institute and a member of Parker's group.

«We established a link between one bacterial species — Lactobacillus reuteri — that is a normal part of the gut microbiome, and the development of a population of cells that promote tolerance,» said Marco Colonna, MD, the Robert Rock Belliveau MD Professor of Pathology and the study's senior author.

What's really impressive about Babar's accomplishment is that he did the work for both papers — one on the role of a population of stem cells in lung cancer development (published in Cell) the other on gene expression in group A Streptococcus (published in PNAS)-- as a participant in summer undergraduate research programs.

With the results from both Korea and the UK the presence of both diet and microbe - induced populations of pTreg cells may be required for the development of complete tolerance to food antigens.

«The ability to generate pure populations of these cell types is very important for any kind of clinically important regenerative medicine,» said Loh, «as well as to develop a basic road map of human embryonic development.

Unlike other studies on p53, however, which target cell populations that average many cells together, Dr. Lahav developed a new approach, quantifying p53 at high temporal resolution in single cells and taking into account that «individual cell decisions are crucial in the development and treatment of cancer.»

In collaboration with experimentalists we use these methods to study self - organization phenomena of cell populations in tissue development, disease and regeneration.

It has been postulated that hypoxia contributes directly to the development of more aggressive cancers by exerting selective pressure on the tumor cell population to favor cells that can survive decreased O2 and nutrients [18 — 20].

These results provide a defined population of human astrocytes suitable for further pre-clinical development for treatment of SCI, and demonstrate that pre-differentiation into astrocytes prior to transplantation provides a much greater functional recovery than transplantation of precursor cells themselves.

In this study, we show that in elderly individuals seropositivity for human CMV leads to the development of oligoclonal populations of CMV - specific CTL that can constitute up to one - quarter of the total CD8 T cell population.

The main focus is on the development of various stem cell populations.

Our study of annelid development reveals a population of mesodermal cells that converge and extend along the ventral midline and express a combination of transcription factors, signaling molecules, and guidance factors that closely matches that of the vertebrate chordamesoderm.

Cultures of unfixed ES cells were sorted into four populations for parallel analysis of gene expression and development in cell culture.

Some of the long term aims of the studies are (i) to contribute to the understanding of the mechanisms that control cortical development and evolution, (ii) to use the knowledge to grow neural stem cell populations of high purity and viability for therapeutic approaches and (iii) to study how neural stem cells can be activated in vivo.

Title: Infiltrating immune cells in breast cancer subtypes Date / Time: Tuesday, April 17 2018, 8:00 am - 12:00 pm CT Author: J.L. Matta et al, Ponce Health Sciences Institute and H. Lee Moffitt Cancer Center Poster # / Location: 5698 / Section 32, Board 4 Hyperlink: http://www.abstractsonline.com/pp8/#!/4562/presentation/7977 Demonstrates the value of combining PAM50 subtype distribution with tumor immune profiling to identify biologically distinct patient populations; the combination of these signatures could be applied to the development of specific immunotherapeutics.

Another potential mechanism through which iodine exacerbates or induces Hashimoto's is by up - regulating Th17 cells, the immune cell subset responsible for tissue destruction in autoimmune disease, and by suppressing development of regulatory T cells, the population that invokes oral tolerance to arrest autoimmune responses (31).