Sentences with phrase «development of embryonic stem cell»

Nevertheless, the religious and political right has decried the development of embryonic stem cell lines, and George W. Bush severed federal funding for their development.

Su - chun Zhang and his colleagues at the University of Wisconsin, Madison, and the University of Bonn, Germany, directed the development of embryonic stem cells stage by stage, using the same growth factors the body uses.

Not exact matches

While the entity generated by deleting or disabling early embryonic genes would produce only an unorganized collection of stem cells, it would do so after a period of what appears to be relatively normal development.

Embryonic stem cells are produced during development by the same process of epigenetic programming that later will produce adult cells such as skin and brain.

The scientists rescued the microcephaly during mouse embryonic development by removing a protein that caused the loss of stem cells.

The latest findings show that genetic defects in the body's ability to manufacture carnitine might be associated with an increased risk of autism because carnitine deficiency interferes with the normal processes by which neural stem cells promote and organize embryonic and fetal brain development.

Some of the researchers at the centre will study the differentiation of stem cells into other cell types, one group by using human embryonic stem cell biology and another by studying early embryo development.

In the United Kingdom, research on embryonic stem cells is legal in the first 2 weeks of their development.

During embryonic development, undifferentiated stem cells accumulate methyl groups and other epigenetic marks that funnel them into one of the three germ layers, each of which gives rise to a different set of adult tissues.

«It's an exciting development, and we await the outcome over the next year to see how well these cells integrate, and if there are any potential adverse reactions,» says Mike Cheetham of the Institute of Ophthalmology at University College London, one site where research is under way into a human embryonic stem - cell treatment for AMD.

During embryonic development of mice, however, the situation is different: To build up the system, all mature blood and immune cells develop much more rapidly and almost completely from stem cells.

The laboratory process, described in the journal Scientific Reports, entails genetically modifying a line of human embryonic stem cells to become fluorescent upon their differentiation to retinal ganglion cells, and then using that cell line for development of new differentiation methods and characterization of the resulting cells.

Further investigation, says Resar, showed that these unusual properties arise from the ability of HMGA1 to turn on several genes involved in the Wnt pathway, a network of proteins necessary for embryonic development and stem cell activity.

The success is thanks to neurons cultivated from embryonic stem cells and the right «cocktail» of ingredients to guide cell development.

Newcastle University and the NorthEast England Stem Cell Institute are aware that the research paper «Derivation of Human Sperm from Embryonic Stem Cells» by a group led by Professor Karim Nayernia has been withdrawn from the academic journal Stem Cells and Development.

Using a nuclear protein expressed in follicle stem cells (FSCs), the researchers found that castor, which plays an important role in specifying which types of brain cells are produced during embryonic development, also helps maintain FSCs throughout the life of the animal.

Changes in cellular metabolites have been shown to regulate embryonic stem cell development at the earliest stages of life.

«Changes in metabolites can regulate earliest stages of development: Findings may offer insights into a variety of disorders, advance embryonic stem cell research.»

Eggan has also been itching to use cloning technology to create embryonic stem cells that could be used to model the development of various diseases, especially diabetes and ALS.

«Even if we can make other cells to look like embryonic stem cells, ES cells allow you to investigate unique aspects of human embryonic development.»

Mouse embryonic stem cells, reported in 1981 by Martin Evans, Matthew Kaufman, and Gail Martin, have allowed scientists to generate genetically customized strains of mice that have revolutionized studies of organismic development and immunity and have provided countless models of human disease.

All of the mice produced normal amounts of SOX2 during development, when the transcription factor plays a critical role in the genesis of embryonic and neural stem cells.

«We studied how the Sox2 gene is turned on in mice, and found the region of the genome that is needed to turn the gene on in embryonic stem cells,» said Professor Jennifer Mitchell of U of T's Department of Cell and Systems Biology, lead invesigator of a study published in the December 15 issue of Genes & Development.

This discovery by the scientists at the CRG provides an insight into stem cell - forming molecular mechanisms, and is therefore of great interest for studies on the early stages of life, during embryonic development.

Salk scientists and colleagues have proposed new molecular criteria for judging just how close any line of laboratory - generated stem cells comes to mimicking embryonic cells seen in the very earliest stages of human development, known as naïve stem cells.

Instead of mimicking the complex 3D organization of the developing pituitary gland, this approach relies on the precisely timed exposure of human pluripotent stem cells to a few specific cellular signals that are known to play an important role during embryonic development.

But the identity of the progenitor, or stem cells, that give rise to Merkel cells during embryonic development and adulthood is unclear.

During embryonic development, organ - specific cell types are formed from pluripotent stem cells, which can differentiate into all cell types of the human body.

The ability of a fertilized egg to generate both embryonic and extra-embryonic tissues is referred to as «totipotency,» an ultimate stem cell state seen only during the earliest stages of embryonic development.

«Studies on embryonic development greatly benefit from the culture system of embryonic stem cells and, more recently, induced pluripotent stem cells.

But Mary Herbert, a reproductive biologist at the University of Newcastle, UK, who is part of a team pursuing mitochondrial replacement, says that mitochondria behave very differently in embryonic stem cells compared to normal human development.

They accomplished this by using mouse embryonic stem cells to manipulate the mouse genome at the very start of development.

Other potential uses of embryonic stem cells include investigation of early human development, study of genetic disease and as in vitro systems for toxicology testing.

Neural crest cells are a type of stem cell; during vertebrate embryonic development, they eventually differentiate into specialized cells such as those that make facial skeleton cells or those that create pigment cells.

Although we agree that greater investments are needed in the clinical development of these therapies, we disagree with the authors» suggestion that, relative to embryonic stem cells, adult stem cells provide a superior vehicle for cell - based therapies because they lack tumorigenic activity, can be prepared by methods approved by the Food and Drug Administration (FDA), and have been free of ethical controversy.

The researchers suggest that since the adult muscle stem cells are only activated when injury occurs (by trauma or exercise), they use a new set of genes from those used during embryonic development, which proceeds without injury.

In parallel, the roles of symmetric and asymmetric cell divisions are investigated as a mechanism for governing stem cell self - renewal and differentiation during embryonic development and in the adult.

A second method involves introducing the transgenic DNA into embryonic stem cells (ES cells) derived from a mouse embryo at the very early stages of development.

My post-doctoral work on the identification of genes required for normal germ line development and fertility led to the discovery that the germ line is exquisitely sensitive to mutations in components of the mitotic spindle that have the potential to lead to aneuploidy — this sensitivity may also extend to embryonic and adult stem cells.

Two recent developments involving the California Institute for Regenerative Medicine (CIRM) again serve to underscore the reality that adult and other non-embryonic avenues of stem cell research are advancing at a far more dramatic pace toward providing actual therapeutic benefits for patients than is human embryonic stem cell research (hESCR).

The grand architecture of the human cortex, with its hundreds of distinct cell types, begins as a uniform layer of neural stem cells and builds itself from the inside out during several months of embryonic development.

«Discovery of a gene that could convert human embryonic stem cells into myocardial cells would be golden,» said Didier Stainier, PhD, UCSF assistant professor of biochemistry and biophysics, the senior author of the UCSF study and a pioneer in the study of heart development in the transparent zebrafish embryo.

Recently, his lab used induced pluripotent stem (iPS) cells — adult cells made to act like embryonic stem cells — made from skin cells of patients carrying apoE4, or other mutations related to Alzheimer's, to study their effects on the development, survival, and degeneration of human neurons.

Professor Martinez - Arias and colleagues, supported by the European Research Council and the Wellcome Trust, have reconstructed these early stages of development using mouse embryonic stem cells.

If ACT will succeed at this stage and will able to show long - term safety, it will shape and determine the future development and commercialization of embryonic stem cell - based products.

Researchers at the University of Cambridge have managed to reconstruct the early stage of mammalian development using embryonic stem cells, showing that a critical mass of cells — not too few, but not too many — is needed for the cells to being self - organising into the correct structure for an embryo to form.

The aorta - gonad - mesonephros (AGM) region in the aortic wall appears to be the most important source of new blood cells, and it has been found to contain numerous hematopoietic stem cells by day 11 of mouse embryonic development.

They discovered that extra chromosome 21 - a genetic state known as trisomy 21 - disturbs a key regulating gene called NRSF or REST, which in turn disturbs the cascade of other genes that control normal development at the embryonic stem cell stage.

2007 also saw one of the most game - changing developments in the stem cell field; researchers learned how to create cells like embryonic stem cells, but instead of coming from an embryo these cells are created from adult cells, potentially cells from any tissue in the human body.

LifeMap Discovery ® is a compendium of embryonic development for stem cell research and regenerative medicine, constructed by integrating extensive molecular, cellular, anatomical and medical data curated from scientific literature and high - throughput data sources.