Sentences with phrase «development of other diseases»

A high intake of added sugar and refined carbs has been linked to the development of other diseases, such as liver disease, inflammatory bowel disease, mental decline, arthritis and others (2, 32, 33, 34).

The immune system is already on super high alert, and introducing more invaders is going to increase * systemic inflammation, which can heighten symptoms not to mention lead to the development of other diseases.

Not exact matches

Important factors that could cause actual results to differ materially from those reflected in such forward - looking statements and that should be considered in evaluating our outlook include, but are not limited to, the following: 1) our ability to continue to grow our business and execute our growth strategy, including the timing, execution, and profitability of new and maturing programs; 2) our ability to perform our obligations under our new and maturing commercial, business aircraft, and military development programs, and the related recurring production; 3) our ability to accurately estimate and manage performance, cost, and revenue under our contracts, including our ability to achieve certain cost reductions with respect to the B787 program; 4) margin pressures and the potential for additional forward losses on new and maturing programs; 5) our ability to accommodate, and the cost of accommodating, announced increases in the build rates of certain aircraft; 6) the effect on aircraft demand and build rates of changing customer preferences for business aircraft, including the effect of global economic conditions on the business aircraft market and expanding conflicts or political unrest in the Middle East or Asia; 7) customer cancellations or deferrals as a result of global economic uncertainty or otherwise; 8) the effect of economic conditions in the industries and markets in which we operate in the U.S. and globally and any changes therein, including fluctuations in foreign currency exchange rates; 9) the success and timely execution of key milestones such as the receipt of necessary regulatory approvals, including our ability to obtain in a timely fashion any required regulatory or other third party approvals for the consummation of our announced acquisition of Asco, and customer adherence to their announced schedules; 10) our ability to successfully negotiate, or re-negotiate, future pricing under our supply agreements with Boeing and our other customers; 11) our ability to enter into profitable supply arrangements with additional customers; 12) the ability of all parties to satisfy their performance requirements under existing supply contracts with our two major customers, Boeing and Airbus, and other customers, and the risk of nonpayment by such customers; 13) any adverse impact on Boeing's and Airbus» production of aircraft resulting from cancellations, deferrals, or reduced orders by their customers or from labor disputes, domestic or international hostilities, or acts of terrorism; 14) any adverse impact on the demand for air travel or our operations from the outbreak of diseases or epidemic or pandemic outbreaks; 15) our ability to avoid or recover from cyber-based or other security attacks, information technology failures, or other disruptions; 16) returns on pension plan assets and the impact of future discount rate changes on pension obligations; 17) our ability to borrow additional funds or refinance debt, including our ability to obtain the debt to finance the purchase price for our announced acquisition of Asco on favorable terms or at all; 18) competition from commercial aerospace original equipment manufacturers and other aerostructures suppliers; 19) the effect of governmental laws, such as U.S. export control laws and U.S. and foreign anti-bribery laws such as the Foreign Corrupt Practices Act and the United Kingdom Bribery Act, and environmental laws and agency regulations, both in the U.S. and abroad; 20) the effect of changes in tax law, such as the effect of The Tax Cuts and Jobs Act (the «TCJA») that was enacted on December 22, 2017, and changes to the interpretations of or guidance related thereto, and the Company's ability to accurately calculate and estimate the effect of such changes; 21) any reduction in our credit ratings; 22) our dependence on our suppliers, as well as the cost and availability of raw materials and purchased components; 23) our ability to recruit and retain a critical mass of highly - skilled employees and our relationships with the unions representing many of our employees; 24) spending by the U.S. and other governments on defense; 25) the possibility that our cash flows and our credit facility may not be adequate for our additional capital needs or for payment of interest on, and principal of, our indebtedness; 26) our exposure under our revolving credit facility to higher interest payments should interest rates increase substantially; 27) the effectiveness of any interest rate hedging programs; 28) the effectiveness of our internal control over financial reporting; 29) the outcome or impact of ongoing or future litigation, claims, and regulatory actions; 30) exposure to potential product liability and warranty claims; 31) our ability to effectively assess, manage and integrate acquisitions that we pursue, including our ability to successfully integrate the Asco business and generate synergies and other cost savings; 32) our ability to consummate our announced acquisition of Asco in a timely matter while avoiding any unexpected costs, charges, expenses, adverse changes to business relationships and other business disruptions for ourselves and Asco as a result of the acquisition; 33) our ability to continue selling certain receivables through our supplier financing program; 34) the risks of doing business internationally, including fluctuations in foreign current exchange rates, impositions of tariffs or embargoes, compliance with foreign laws, and domestic and foreign government policies; and 35) our ability to complete the proposed accelerated stock repurchase plan, among other things.

Founded in 2011, Innovent has built a portfolio of 16 potential products for treating cancer, autoimmune disorders and other diseases, and seven of those are in clinical development.

Perhaps this will include research and development of drugs for other diseases, albeit with fewer researchers, but to date, neither the amount the company will save nor its specific use of these freed - up resources has been detailed.

Minoryx is a clinical stage biotech company leading the development of new therapies for X-linked Adrenoleukodystrophy (X-ALD) and other inborn errors of metabolism, a group of rare diseases of genetic origin with a high unmet medical need.

Contamination from upstream tar sands / oil sands development is causing higher levels of cancer and other serious disease for members of the Athabasca Chipewyan and...

About five percent are used for teaching purposes, another five percent for diagnosis of disease, twenty percent for production of biological substances («biologicals») and for toxicity testing, thirty percent in development of drugs and their testing, and forty percent for other research activities such as the present work in genetic engineering to increase the size of sheep and pigs.

The development of functional products follows the decades - long dichotomy of a pandemic of obesity and concomitant diseases (especially diabetes), with consumers who are increasingly informed on the details of nutraceutical and other functional ingredients and the science behind them.

Because many kids don't eat these kinds of fish, and some parents believe that fish oil may also promote brain development and help prevent other diseases, many give their kids a high omega - 3 fish oil supplement with DHA and EPA.

Research in the United States, Canada, Europe, and other developed countries, among predominantly middle - class populations, provides strong evidence that human milk feeding decreases the incidence and / or severity of diarrhea,1 - 5 lower respiratory infection,6 - 9 otitis media,3,10 - 14bacteremia, 15,16 bacterial meningitis, 15,17 botulism, 18 urinary tract infection, 19 and necrotizing enterocolitis.20, 21 There are a number of studies that show a possible protective effect of human milk feeding against sudden infant death syndrome,22 - 24insulin - dependent diabetes mellitus,25 - 27 Crohn's disease, 28,29 ulcerative colitis, 29 lymphoma, 30,31 allergic diseases,32 - 34 and other chronic digestive diseases.35 - 37 Breastfeeding has also been related to possible enhancement of cognitive development.38, 39

The longer an infant is breastfed, the less risk for development of other allergic diseases such as asthma and eczema.

Breastfeeding also supports healthy brain development, higher educational achievement, and lowers the risk of obesity and other chronic diseases.

Although breastfeeding has modest effects on blood pressure (51) and adiposity (52, 53) in later life, it has numerous other health benefits, including protection against infectious disease morbidity (54) and mortality (55) in infancy and a lower risk of type 2 diabetes (56) and improved neural and psychosocial development in the longer term (57, 58).

New findings published in eLife draw connections between some of these pieces, revealing an extensive web of molecular interactions that may ultimately inform the development of new epigenetic drugs for cancer and other diseases.

Other collaborations that are currently being discussed focus on the development of small molecules that could disrupt «kidney» (Malphigian tubule) function in mosquitoes, on the differences in the ability to transmit disease among various populations of Aedes aegypti and other mosquitoes, and on advances in the surveillance of adult mosquiOther collaborations that are currently being discussed focus on the development of small molecules that could disrupt «kidney» (Malphigian tubule) function in mosquitoes, on the differences in the ability to transmit disease among various populations of Aedes aegypti and other mosquitoes, and on advances in the surveillance of adult mosquiother mosquitoes, and on advances in the surveillance of adult mosquitoes.

The stocks are helping the development of new countermeasures such as drugs, vaccines and diagnostics in case smallpox should reappear, and may also allow researchers to explore the impact of smallpox on the human immune system, providing insights into other diseases such as AIDS.

Mid-career and more senior Franklin Fellows, both sponsored and self - nominated, work on global issues of vital importance to the United States, such as the environment; counterterrorism; human rights; consular matters; international development assistance; HIV / AIDS and other trans - national diseases; trade, energy and financial policy; and many others.

It could also lead to the development of new therapies against other more common neurodegenerative disorders of the central nervous system, as well as diseases related to the propagation of pathological proteins, including Parkinson's and Alzheimer's.

«After disease develops, we may not be able to prevent the development of other chronic diseases.

«Our findings will promote the development of specific small - molecule drugs useful to treat Graves» disease and other dysfunctions of GPHRs.»

Other treatments, such as radiation, can affect the heart arteries and cause the development of coronary artery disease or blockages.

Disease - driving mechanisms vary and include, among others, the pruning of neuronal synapses, effects on CNS development in utero, and inflammation.

«It is expected that this study will lay the foundation for developing a new class of potent and effective cancer therapies and the development of reagents targeting epigenetic events in immune - mediated diseases as well as other epigenetically - influenced diseases,» said Alani, who also is chief of dermatology at Boston Medical Center.

«Our study enabled us to show for the first time that each of these three parameters — virus load, virus diversity and infection duration — influences the development of broadly neutralizing antibodies independently of each other,» explains Huldrych Günthard, professor of clinical infectious diseases at UZH.

These in turn depend on development of brain imaging tests or biomarkers that could be measured in the blood or other body fluids to allow a diagnosis of the disease in living people.

Wherever the answer lies, the insights could help in the development of vaccines against other diseases that, like HIV, don't easily succumb to immune attack and that kill millions of people.

Prof. Schuelke emphasizes: «Our results are a good example of how the study of rare genetic diseases can provide insights into general disease mechanisms, which may also play a role in other conditions, such as paraplegia, and which may give rise to the development of regenerative therapies.»

Italy is already beginning to show its promise with the development of gene - therapy techniques and the discovery of genes that could lead to a cure for Parkinson's disease and other neurodegenerative disorders.

The results provide the foundation for development of the broad - spectrum cell - directed antivirals or their combinations for treatment of Zika and other emerging viral diseases.

«Although the effects of the drug were modest, we now know that we can influence the course of the disease, and we expect to build on this success with other drugs, including some already in development,» said senior author, Gary K. Schwartz, MD, professor of medicine and chief of hematology / oncology at NewYork - Presbyterian / Columbia University Medical Center and associate director of its Herbert Irving Comprehensive Cancer Center.

While the disease can take many forms, recent advances have better characterized how lymphoma cells proliferate and interact with other cells and tissues, leading to the development of powerful, targeted therapies with fewer side effects than traditional approaches.

«Future research to clarify the mechanisms underlying the link between PTSD and heart disease in Vietnam veterans and other groups will help to guide the development of effective prevention and treatment strategies for people with these serious conditions.»

But amid this governmental turmoil, another, longer - term development is under way that will affect the lives of everyone in the U.S. and take its toll on others around the world — the loss of critical expertise and capacity in the science agencies of the federal government, including the Environmental Protection Agency, the Centers for Disease Control and Prevention, the Occupational Safety and Health Administration, the National Oceanic and Atmospheric Administration, and the National Aeronautics and Space Administration, among many others.

Fresh insights into how our cells control muscle development could aid understanding of muscular dystrophy and other inherited diseases.

Professor Fallon said: «This identification of an early stage cellular checkpoint that can act as a break on allergic responses has important implications for the development of new therapeutic approaches for asthma and other allergic diseases.»

«This could postpone the development of age - related diseases,» said Mark Y. Jeng, the study's other first author and former graduate student in Ott's lab.

This may contribute to the development of stem cell therapy targeted at other diseases.

Along with animal studies, these observations suggest that the balance of bacteria and other microbes help guide immune development — and that when the balance is disrupted, disease may follow.

Breast cancer cells that spread to other parts of the body break off and leave the primary tumour at late stages of disease development, scientists from the Wellcome Trust Sanger Institute and their collaborators have found.

To date, the present study is the largest to investigate the association between levels of long - chain omega - 3 and omega - 6 fatty acids in the blood and subsequent development of asthma and other allergic diseases.

«KSR belongs to a large class of proteins that are not only implicated in the development of cancer, but also other diseases as well,» Dr. Dar explained.

The new finding is the latest evidence supporting a growing precision medicine model of psychiatric disease in which disruptions of certain genes during brain development contribute to a person's risk for multiple psychiatric disorders, with other genetic or epigenetic drivers, random developmental events, or environmental influences determining the specific disease an individual develops, said senior author Benjamin Cheyette, MD, PhD, an associate professor of psychiatry and a member of the UCSF Weill Institute for Neurosciences and the Kavli Institute for Fundamental Neuroscience at UCSF.

LSDs remain the heart of our company today, but we have also expanded — through both in - house development and strategic acquisitions and partnerships — to other disease areas such as thyroid cancer and multiple sclerosis.

Josef Decosas of the Canadian International Development Agency believes that policy makers must focus on overall health in developing countries, rather than malaria, or AIDS, or TB, or any other single disease.

Compared with the development of new drugs to treat other diseases, «Alzheimer's drug development is more expensive, takes longer, and needs a larger sample of potential patients,» Lo acknowledges.

«These results raise the distinct possibility that there are other pathways — such as inflammation in the brain — that are just as important in the development of Alzheimer's disease.»

«So now that we have seen this environmental toxicant - induced inflammation, we can study the beneficial anti-inflammatory foods, like the purple potato and others, in this human development model, and see how a mother's health and her levels of toxicants and beneficial compounds will influence the baby's susceptibility to chronic disease.»

They add: «What is similar between now and then is the human genetic material, our genome, including ancient polymorphisms that were uncovered to predispose the carrier to the development of atherosclerotic cardiovascular disease... however, our ancient ancestors were certainly susceptible to many other conditions, such as infectious diseases, nutritional deprivation, and trauma, which often resulted in death at an early age, before atherosclerotic heart disease had a clinical impact.»

One concern is the development of multiple sclerosis, which has been fuelled by social and news media reports of cases occurring after HPV vaccination, and an increasing number of case reports published in the medical literature describing vaccine recipients who developed multiple sclerosis as well as other demyelinating diseases.