Sentences with phrase «development of side effects»

Based on any previous veterinary treatments (diets, medications, therapies) for the current problems, have you noted any worsening of clinical signs or development of side effects?

Nearly all types of chemotherapy require close monitoring to watch for the development of side effects.

In the treatment of intestinal protozoan infections... drugs are generally so toxic that they can not be administered for prolonged periods of time, whereas GSE can be administered for weeks or months; prolonged treatment being essential for the cure of chronic protozoan infections... I have had some immunosuppressed patients taking the preparation for over a year with no apparent development of side effects or drug resistance.»

Not exact matches

These risks and uncertainties include, among others: the unfavorable outcome of litigation, including so - called «Paragraph IV» litigation and other patent litigation, related to any of our products or products using our proprietary technologies, which may lead to competition from generic drug manufacturers; data from clinical trials may be interpreted by the FDA in different ways than we interpret it; the FDA may not agree with our regulatory approval strategies or components of our filings for our products, including our clinical trial designs, conduct and methodologies and, for ALKS 5461, evidence of efficacy and adequacy of bridging to buprenorphine; clinical development activities may not be completed on time or at all; the results of our clinical development activities may not be positive, or predictive of real - world results or of results in subsequent clinical trials; regulatory submissions may not occur or be submitted in a timely manner; the company and its licensees may not be able to continue to successfully commercialize their products; there may be a reduction in payment rate or reimbursement for the company's products or an increase in the company's financial obligations to governmental payers; the FDA or regulatory authorities outside the U.S. may make adverse decisions regarding the company's products; the company's products may prove difficult to manufacture, be precluded from commercialization by the proprietary rights of third parties, or have unintended side effects, adverse reactions or incidents of misuse; and those risks and uncertainties described under the heading «Risk Factors» in the company's most recent Annual Report on Form 10 - K and in subsequent filings made by the company with the U.S. Securities and Exchange Commission («SEC»), which are available on the SEC's website at www.sec.gov.

Agios Pharmaceuticals shares plunged more than 18 percent after the company discontinued development of an experimental drug for rare blood disorder due to side effects seen in a study.

It tells the story of «the guinea pigs»» the people most likely to be research subjects in Phase I trials, which test the safety of a drug under development by giving it to healthy subjects and examining any side effects they experience.

Furthermore, antibiotics can cause side effects and lead to development of antibiotic resistance.

52 The American Academy of Pediatrics cautions that «corporal punishment is of limited effectiveness and has potentially deleterious side effects,» and «recommends that parents be encouraged and assisted in the development of methods other than spanking for managing undesired behavior.»

Their first visit was to CytoCybernetics, where CEO Glenna Bett explained how her company has developed a system that uses computers and live human cells to screen drugs in their early stages of development, to determine whether they may cause any potentially deadly side effects.

«Our research has led to the development of a test that can detect patients that will benefit from treatment up front and spare those who are at lower risk from the side - effects of chemotherapy.

University of California, Berkeley and Harvard Medical School researchers were studying how certain bacteria influence multicellular development in the unicellular choanoflagellate Salpingoeca rosetta when they observed the unexpected side effect.

TRPV1 blockers are already the focus of intense research and development, but these compounds come with side effects.

Sometimes, toxic side effects aren't discovered until fairly late in the drug development process, when substantial amounts of time and money have already been invested in clinical trials.

In upcoming investigations, the scientists want to verify their findings on the development of liver cancer and search for active substances that inhibit apoptosis while simultaneously causing the mildest possible side effects.

While the disease can take many forms, recent advances have better characterized how lymphoma cells proliferate and interact with other cells and tissues, leading to the development of powerful, targeted therapies with fewer side effects than traditional approaches.

Researchers in Sweden have just identified a number of drug targets that can be used in the development of new efficient treatment strategies with minimum side effects.

These structures can be mutated to better understand how they influence the Zika virus infection in humans and can also potentially lead to the development of a safe vaccine that has reduced side effects.»

There has been a decrease in side effects due to the development of better treatments, limiting the use of radiation.

Poirier hopes that with further funding and support, his studies will lead to the development of drugs targeted to specific genotypes, making them safer and more effective and reducing side effects.

Pharmacogenomics — the study of how genes affect responses to drugs — is becoming more important in drug - development research and clinical trials, with a view toward decreasing side effects and increasing the efficiency and efficacy of drugs in patients with the right genetic profiles.

More concerning, niacin was associated with an increased trend toward death from all causes as well as significant increases in serious side effects: liver problems, excess infections, excess bleeding, gout, loss of control of blood sugar for diabetics and the development of diabetes in people who didn't have it when the study began.

The findings hold promise for the development of novel targeted therapies with fewer harmful side effects.

This, in turn, opens the doors to the development of new anesthetics that would not have depressed heart function as a side effect.

The prevailing theory of the evolution of aging holds that aging is a side effect of genes that promote growth and development of organisms that have a low likelihood of continued survival in the wild once they have reproduced.

A team at the Wyss Institute for Biologically Inspired Engineering designed a better variant of the widely - used drug erythropoietin (EPO), showing how rational design can improve in vivo efficacy and safety of protein therapeutics, reduce potential side effects, and also accelerate new drug development.

Unlike opioid narcotics that target other opioid receptors, these compounds do not produce a «high» or increased risk of overdose; however, they can deplete the body's supply of dopamine and produce dysphoria and sedation, side effects that have limited their clinical development.

That in turn could lead to the development of new drugs with fewer side effects and less of a social stigma, he says.

Adding to the challenge are the side effects of rapid economic development: air pollution, contaminated water, and encroaching urbanization, all of which threaten Chinese farmland.

They say that their report, which appears in ACS» Journal of Agricultural and Food Chemistry, could lead to the development of natural products that ward off dental diseases with fewer side effects.

This scientific breakthrough is of huge importance for the well - being of patients suffering from pain, since, in the short term, it will allow the development of more efficient painkillers with fewer side - effects.

Scientists from the University of Granada have taken part, alongside the Esteve laboratory, in the development of a new drug that multiplies the analgesic effect of opioids (drugs for treating intense pain), without increasing constipation, one of the most common side - effects of these drugs, among which is morphine.

F. Minimize cancer treatment's debilitating side effects Accelerate the development of guidelines for routine monitoring and management of patient - reported symptoms to minimize debilitating side effects of cancer and its treatment.

We're seeing encouraging results, including the development of more effective drugs with increased efficacy and decreased toxicity, and the ability to better use existing ones, with improved delivery and fewer side effects.

According to Andreassen, the study's senior author, some think of schizophrenia as a «side effect» arising from advantageous variants in genes that are related to the development of human traits, such as cognitive and language skills, that may have increased risks for developing psychoses.

The objectives of the guidelines for the rational and responsible use of antimicrobials are: - Optimal outcome for male and female patients - Optimal use of antibiotics (range, mode of administration, dose, duration)- Minimizing side effects, such as adverse effects, development of resistance, nosocomial infections, C. difficile infections and costs The basics of the guidelines are evidence, international and national guidelines, the epidemiology of antimicrobial resistance at the USZ and the ex-factory prices of drugs.

Another side effect of irregular development is reduced fertility, which is an increasing problem around the globe.

Anabolic steroid abuse has been associated with a wide range of adverse side effects ranging from some that are physically unattractive, such as acne and breast development in men, to others that are life threatening, such as heart attacks and liver cancer.

Unless scientists develop beta - adrenergic stimulants which would be applied to brown fat only, there is a potential risk for the development of many negative cardiovascular side effects or drastic mood swings and disturbances which were experienced with clenbuterol and products containing ephedrine.

The scientists behind Rozerem's development explain that by targeting melatonin receptors — which are responsible for the brain's sleep - wake cycle — it may avoid the groggy side effects of sedative drugs, which work by slowing down the central nervous system.

Many of you must be in search of the best muscle building supplement that offers safe and effective muscle mass development minus any side effects.

Utilized for more than 2 - 3 days, these commonly used OTC cold medications can lead to the development of unwanted side effects, such as dizziness, stomach upset, dry nose and mouth, heart rate irregularities, anxiety, and grogginess, just to name a few.

While fitting into your favorite skinny jeans is certainly a valuable side effect of MMT, my plan's primary aim goes much deeper — to heal your metabolism at the cellular level and ward off the development of most common chronic diseases and premature aging, including:

If you were to compare a mechanic's forearm development to a bodybuilders, 99 % of the time a mechanic will win hands down (despite it just being a side effect of his job description).

The delicate balance between the human microbiome and the development of psychopathologies is particularly interesting given the ease with which the microbiome can be altered by external factors, such as diet, 23 exposure to antimicrobials24, 25 or disrupted sleep patterns.26 For example, a link between antibiotic exposure and altered brain function is well evidenced by the psychiatric side - effects of antibiotics, which range from anxiety and panic to major depression, psychosis and delirium.1 A recent large population study reported that treatment with a single antibiotic course was associated with an increased risk for depression and anxiety, rising with multiple exposures.27 Bercik et al. 28 showed that oral administration of non-absorbable antimicrobials transiently altered the composition of the gut microbiota in adult mice and increased exploratory behaviour and hippocampal expression of brain - derived neurotrophic factor (BDNF), while intraperitoneal administration had no effect on behaviour.

Some of the other maca root side effects in some people are: • skin allergy or a flushed skin appearance • headache • heartburn • upset stomach • development of goiter

Perry Renshaw, MD, PhD, director of the Brain Imaging Center at McLean Hospital and senior author stated, «The development of an inexpensive, widely available intervention such as yoga that has no side effects but is effective in alleviating the symptoms of disorders associated with low GABA levels has clear public health advantage.

The main drawback with the ketogenic diet was difficult tolerability and high dropout rates — given the extremely positive results and the severe side effects common with antiepilepsy medication, the development of an easier - to - follow ketogenic diet would be a worthwhile goal.5

Western countries have achieved really impressive level of civilization development but unluckily democracy and wealthy life have side effects like exaggerated emancipation.

«The side - kick effect: Mentoring relationships and the development of social capital.»

The 56 % meeting or exceeding standard for CA's grade 11 E / LA result was an outlier with blinking red lights that defies meaningful interpretation other than a grossly discrepant cut score (to the low side) or some other test development flaw (such as an inadequate item bank for a computer - adaptive test) or an error in the test administration or scoring process, or some weird effect due to the increased number of grade 11 students with scores since EAP moved from voluntary to mandatory in 2015 [which usually would involve a decrease in scores, a reasonable interpretation for the decrease in Math EAP scores this year, rather than an increase in scores].