«The increased suicide risk for patients with long - standing benzodiazepine use may be partly attributable to the possible
development of withdrawal symptoms when the drugs run out,» says Professor Tiihonen.
But, we know that smokers with depression have more severe tobacco
withdrawal symptoms, experience more craving and these factors could be targets
of future treatment
development.
Some common
symptoms of tolerance include increasing anxiety, panic attacks,
development of agoraphobia for the first time, interdose
withdrawal (
withdrawal symptoms emerging in between doses), as well as a plethora
of other physical / neurological / psychological
symptoms.
As a result, they tend to spend more time onlooking (watching other children without joining) and hovering on the edge
of social groups.8, 11 There is some evidence to suggest that young depressive children also experience social impairment.12 For example, children who display greater depressive
symptoms are more likely to be rejected by peers.10 Moreover, deficits in social skills (e.g., social participation, leadership) and peer victimization predict depressive
symptoms in childhood.13, 14 There is also substantial longitudinal evidence linking social
withdrawal in childhood with the later
development of more significant internalizing problems.15, 16,17 For example, Katz and colleagues18 followed over 700 children from early childhood to young adulthood and described a pathway linking social
withdrawal at age 5 years — to social difficulties with peers at age 15 years — to diagnoses
of depression at age 20 years.