Sentences with phrase «development signaling pathways»

Not exact matches

The AXIN2 protein interacts with proteins in the Wnt signalling pathway, which is involved in controlling many cellular processes, including development.

It was deep in the TGF — beta signaling pathway in a gene involved with uvula development.

That finding confirms the important role these signaling pathways play in dental development.

«We discovered that three particular proteins involved in the Wnt signaling pathway aren't just involved in the development of severe illnesses, but also in the qualitative refinement of highly developed tissue,» says co-first author Claudio Cantù from the molecular biologist research group lead by Prof. Konrad Basler.

Now, Dr. Katharina Walentin and Professor Kai Schmidt - Ott of the Max Delbrück Center for Molecular Medicine (MDC) Berlin - Buch have discovered a new molecular signaling pathway which regulates the development of the placenta.

In addition to the COX enzyme pathway, Dr. Roberts says other studies have shown that aspirin blocks additional cell - signaling cascades that promote cancer development.

Previous research by Lee's lab had shown that p75 is involved in a signaling pathway that regulates the development of sensory neurons — cells which transmit our sensation of pain, touch and muscle tension — in the dorsal root ganglia.

If plastic harms, it does so by stealth: by mimicking our own hormones, by scrambling signals during development, by stimulating our own pathways excessively.

Understanding how this signaling pathway functions would allow for development of strategies to protect crops against climatic change and to improve photosynthesis so as to generate biofuels and other valuable products.

Meanwhile, cancer genome projects have yielded unprecedented insights into the cellular signaling pathways that drive the development and progression of cancer — information that has led to effective therapies tailored for individual patients.

This signaling pathway could be used to optimize the photosynthetic efficiency of plants subject to water and nutrient deficiencies, with potential applications in agriculture and reactor - based crop development for green chemistry and algae - based biofuel solutions.

Researchers at CNRS, CEA and Université d'Aix - Marseille have demonstrated that an ancient signaling pathway inherited from bacteria impacts plant growth and development.

They were interested in one of the cell's key signaling pathways, the MAPK pathway, which helps control cell growth, embryonic development, and the maturation of oocytes into eggs.

Through many painstaking experiments, she zeroed in on a signaling pathway called Wnt, known to be important in mouse lung development.

Researchers at the Center for Regenerative Medicine (CReM) at Boston University School of Medicine (BUSM) and Boston Medical Center (BMC) have discovered that one particular signaling pathway, Wnt, helps direct lung development.

One of the top defective pathways in the iPSCs was the Wnt signaling pathway, which plays an important role in neuronal development.

Her research has recently shown that a signaling pathway dubbed «hedgehog» is important not only for normal development of stem cells but also for the growth of cancer cells in chronic myelogenous leukemia.

«We're seeing more and more often now that [fruit flies] and vertebrates use the same signaling pathways over and over again in many stages of development.

Now that we have discovered how Group A strep bacteria communicate with each other to coordinate the production of this toxin, we can target the signaling pathway for vaccine and antimicrobial development.»

In addition to NANCI, the team identified another lncRNA, which they named LL34, that regulates retinoic acid signaling, another important pathway for early lung development.

«Recently, the attention of scientists has been attracted to endocrine - disrupting chemicals (EDCs), compounds that are suspected of promoting the development of various metabolic disorders via their capacity to impact hormonal and metabolic signaling pathways,» said lead author Shane Regnier, a doctoral candidate at the University of Chicago's Committee for Molecular Metabolism & Nutrition.

NANCI appears to act upstream of Nkx2.1, but down - stream of Wnt signaling, a critical pathway for specifying cell type later in lung tissue development.

Dr. Yaffe's research focuses on the biology of the complex signaling pathways that cells use to respond to DNA damage and inflammation, particularly the role of protein kinases and modular binding domains in tumor development and anti-cancer therapeutics.

A related study, also published in PLOS Genetics, shows that RPM - 1 functions as a part of a novel pathway to control β - catenin activity — this is the first evidence that RPM - 1 works in connection with extracellular signals, such as a family of protein growth factors known as Wnts, and is part of larger signaling networks that regulate development.

The inhibition of this signaling pathway by NT219 protected worms from toxic protein aggregation that in humans is associated with the development of Alzheimer's or Huntington's disease.

Knockdown of LL34 expression leads to decreased retinoic acid signaling, suggesting that this lncRNA may play an early role in the development of the lung, as well as other tissues controlled by this pathway.

«In that way, we followed changes in the pleura throughout disease development, observing stages of chronic inflammation, activation of pro-oncogenic signaling pathways, and eventually inactivation and / or loss of genes that are the gatekeepers of cancer development,» MacFarlane says.

At the University Children's Hospital Zurich, researchers from the University of Zurich have identified a signaling pathway in liver cells that may contribute to the development of steatosis.

In the new study, the researchers discovered that during the second trimester of human brain development, oRG cells express genes related to a fundamental signaling pathway called mTOR, defects in which have previously been implicated in autism and several other psychiatric disorders.

«Secret alter ego of well - known protein fights leaky blood vessels: Surprise discovery of a new pathway governed by Notch signaling protein opens door for better drug development.»

Poznansky's team — with lead scientist Huabiao Chen, PhD, corresponding author of the current report — had been investigating applications of AMD3100, a drug that blocks the CXCR4 / CXCR12 signaling pathway known to be involved in cancer development and in the way in which mesothelioma evades the immune system.

With the knowledge that fibrosis appears to radiate from blood vessels, Humphreys and colleagues examined the hedgehog signaling pathway, which normally regulates organ development but whose roles in the adult are less clear.

In this study scientists used cells from the fruit fly Drosophila to screen for small molecules that suppress the signalling pathway central to the development of MPNs in humans.

RABEX - 5 is upregulated and plays an oncogenic role in gastric cancer development by activating the VEGF signaling pathway.

The Notch1 - Dll4 signaling pathway regulates mouse postnatal lymphatic development.

Dr. Levitsky: My organization within Roche, Pharma Research and Early Development (pRED), has invested in antibody engineering, not only for use of monoclonal antibodies in the established ways of delivering cell - killing agents to tumors or interrupting cell signalling pathways, but also as ways to engage and manipulate the immune system's response to tumors.

The ortholog genes that were found to be associated with cartilage development, along with bmp which acts as a key member gene, are known to be involved in the Wnt signaling pathway (Kim et al., 2013; Lin & Hankenson, 2011).

This signaling pathway was found to be important in embryonic bone development (Wan et al., 2013), and in osteoblasts (bone cells) regulation (Glass et al., 2005; Harada & Rodan, 2003).

Dr. Joyal has over 20 years of drug discovery experience with expertise in cell and molecular biology, particularly in the areas of receptor biology, cell signaling pathways, and assay development.

Furthermore, in this signaling pathway the Met gene plays an important role in the development of Klatskin carcinoma.

The evidence of ortholog genes expression which likely associated with Smad proteins, Wnt, TGF - β signaling pathways, and cartilage formation in S. pistillata supports previous reports suggesting that gene regulatory pathways of development and biomineralization processes across the metazoan evolution are considerably conserved (Jackson et al., 2007; Marin et al., 2008).

With the recent development, by our group, of cell - permeant NAADP (NAADP - aceteoxymethyl ester) and a selective NAADP receptor antagonist (Ned - 19; 1 -(3 --LRB-(4 -(2 - fluorophenyl) piperazin -1-yl) methyl)-4-methoxyphenyl)-2,3,4,9-tetrahydro-1H-pyrido [3,4 - b] indole -3-carboxylic acid), the ability to investigate this signaling pathway has improved.

The Role of CXCL12 - CXCR4 Signaling Pathway in Pancreatic Development Keiichi Katsumoto, Shoen Kume Theranostics 2013; 3 (1): 11 - 17.

While core pathways for BR metabolism and signaling have largely been defined, little is known about the molecular mechanisms regulating BR homeostasis and how these in turn modulate plant development.

8.30 Hana Paculová CDK12 connects transcriptional regulation to DNA damage repair pathway 8.55 Karol Kaiser Wnt secretion during nervous system development 9.20 Simona Hankeová The role of Notch signaling in vasculogenesis 10.00 Coffee break 10.30 Tomáš Doležal Extracellular adenosine regulates complex host - pathogen interactions through the energy release for the immune response 10.55 Ondřej Bernatík and Igor Červenka Regulation of diverse function of Dvl by phosphorylation 11.20 Jan Ryneš Dissection of Axin interactome: rational approach for control of signaling cascades via intervention with specific protein - protein interactions 12.05 Targeting opportunities: discussion & sum - up 13.00 Lunch and departure

Researchers have discovered that genetic mutations underlying two inherited eye disorders arise in different components of a single intracellular signaling pathway that is responsible for development...

«Our findings suggest that apoE4 inhibits the development of newborn neurons by impairing specific signaling pathways and that boosting these pathways with drugs may be of therapeutic benefit,» said Dr. Huang.

The researchers also identified new links between aggressive meningioma proliferation and activation of an intercellular signaling pathway called Wnt — which typically plays a role during embryonic development and tissue formation.

Metlakunta AS, Sahu M, Sahu A. Hypothalamic phosphatidylinositol 3 - kinase pathway of leptin signaling is impaired during the development of diet - induced obesity in FVB / N mice.

Using the wing development of the fly Drosophila melanogaster as a model, Professor Milán studies the signalling pathways and genetic circuits required for tissue development, and new pathways involved in regeneration and cancer.