«We don't know if the observed reversibility of the disease symptoms as observed in the mouse,» he says, «exists in humans who have a much longer period of pre - and post-natal brain
development than mice — months and years in humans, weeks in mice.»
Therefore, LMU researchers argue that bovine embryos might well be a better model for early human
development than the mouse system.
Not exact matches
Yet, in
mouse embryos the researchers found that the human enhancer was active earlier in
development and more active in general
than the chimpanzee enhancer.
Neurobiologist Gordon Fishell lost about 2,500
mice representing 40 genetic variants, which he had developed for studies of forebrain
development over more
than a decade.
Psychologists hope that a deeper understanding of how our left and right hands cooperate will lead to the
development of intuitive two - handed user interfaces that give us more control over computers
than the
mouse we use with one hand today.
Speroni said, «We now have a way to test the impact of endocrine - disrupting chemicals on the
development of the
mouse mammary gland at different doses and obtain results in less
than a week.»
When a strain of
mice genetically destined to develop a form of TLR7 - dependent lupus was crossbred with a strain in which TREML4 expression was suppressed, offspring lacking TREML4 were protected from the
development of lupus - associated kidney failure and had significantly lower blood levels of inflammatory factors and autoantibodies
than did
mice expressing TREML4.
Further testing found these
mice had lower -
than - expected growth hormone and insulin - like growth factor (IGF1) levels in the blood, potentially explaining the small stature and delayed
development seen in human patients.
The discovery may help explain why humans evolved more elaborate brains
than mice, and it could suggest ways to treat disorders such as autism and epilepsy that arise from abnormal neural
development.
In addition, this is not the only case in which the regulatory circuits that control early embryonic
development in humans show greater similarity to those employed in bovine embryos
than to those that operate in the
mouse system.
George was interested in using a vertebrate model that was physiologically simpler
than the
mouse, so that he could study the
development and function of the nervous system.
We speculated that this could be due to the poor
development of the lymphoid tissues in these
mice rather
than the inherent inability of the HPCs to develop into lymphoid cells.
More
than half of the approximately 25,000 genes in the
mouse genome are thought to be involved in
development and function of the nervous system [1, 2], but only 30 % of genes have any function assigned to them [3].
The chronically stressed
mice had decreased immune function and experienced tumor
development significantly earlier
than the non-stressed
mice.16 Other
mouse studies of ovarian cancer showed that chronic stress resulted in increased cancer growth as well as increased angiogenesis, the process with which cancer forms new blood vessels to feed itself nutrients for growth and metastases.17 Chronic stress has also been shown to decrease our body's ability to mount an attack against foreign invaders, including viruses.18 As we know that several viruses can cause cancer (HPV and cervical cancer, and EBV and nasopharyngeal cancer), we can extrapolate that any decrease in immune function could increase cancer risk.
However, TPH2 − / −
mice were not different from wild - type controls on any of these tests and in some cases were more resistant to the
development of depression - like behaviors
than wild - type controls.»