The major challenge is getting closer to a mechanistic understanding of why type 2
diabetes and obesity occur and why they have become so much more common in the last 40 - 50 years.
Not exact matches
One of the most common pregnancy complications, gestational
diabetes affects one in 10 expectant women —
and because it
occurs more often among obese women, rates of GDM in the United States have been rising along with
obesity rates.
Sarcopenia — the significant loss of muscle mass
and function that can
occur as we age — is associated with many chronic conditions such as
diabetes, high cholesterol
and obesity.
NAFLD, which is characterized by the build up of extra fat in liver cells, is associated with
obesity and diabetes,
and it
occurs with minimal or no symptom until the disease is advanced.
Most likely they both
occur in most conditions of
obesity and type II
diabetes.
We need to understand how these adaptations between generations
occur since these may help us understand the record levels of
obesity and type 2
diabetes in our society today.»
Angela C Estampador, 1,2 Paul W Franks1, 3,4 1Department of Clinical Sciences, Genetic
and Molecular Epidemiology Unit, Lund University, Skåne University Hospital Malmö, Malmö, Sweden; 2Department of Endocrinology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark; 3Department of Public Health
and Clinical Medicine, Umeå University, Umeå, Sweden; 4Department of Nutrition, Harvard School of Public Health, Boston, MA, USA Abstract: Evidence has emerged across the past few decades that the lifetime risk of developing morbidities like type 2
diabetes,
obesity,
and cardiovascular disease may be influenced by exposures that
occur in utero
and in childhood.
′ Blood oranges contain naturally
occurring pigments associated with improved cardiovascular health, controlling
diabetes and reducing
obesity, ′ said Professor Cathie Martin from the John Innes Centre on Norwich Research Park.
Dr. Kelly will present findings on a recently discovered cellular glucose sensor in muscle that serves as a key connection between insulin resistance
and accumulation of fat in muscle, which
occurs in
obesity - related
diabetes.
A potential explanation for the secular trend may be that while improved treatment for cardiovascular risk factors or complicating diseases has reduced mortality in all weight classes, the effects may have been greater at higher BMI levels than at lower BMI levels.12 Because
obesity is a causal risk factor for hypertension,
diabetes, cardiovascular disease,
and dyslipidemia,15,19 - 22 obese individuals may have had a higher selective decrease in mortality.18 Indirect evidence of this effect is seen in the findings as the deaths
occur at similar time periods in the 3 cohorts, but cohorts recruited at later periods have an increase in the BMI associated with the lowest mortality, possibly suggesting a period effect related to changes in clinical practice, such as improved treatments, or general public health status, such as decreased smoking or increased physical activity.
In early 1977, the committee released the Dietary Goals for Americans, blaming what they saw as an «epidemic» of killer diseases —
obesity,
diabetes, heart disease
and cancer — on changes in the American diet that had
occurred in the previous fifty years, specifically the increase in «fatty
and cholesterol - rich foods.»
This decrease in sleep duration has
occurred over the same time as the increase in the prevalence of
obesity and diabetes.
This is important, since high cholesterol, heart disease,
obesity and Type - 2
diabetes tend to
occur in unison.
Dr. Tove Fall, lead study researcher at the Department of Medical Sciences
and the Science for Life Laboratory at Uppsala University commented, «We knew already that
obesity and cardiovascular disease often
occur together... in this study we found that individuals with gene variants that lead to increased body - mass index also had an increased risk of heart failure
and diabetes.»
The issue with inflammation is that in can
occur chronically at low levels because chronic inflammation is seen to increase your risk of
obesity,
diabetes, depression,
and heart disease (33, 34, 35).
Additionally, the elevated insulin will increase D2 activity
and suppress TSH levels, further decreasing thyroid levels
and making it inappropriate to use the TSH as a reliable marker for tissue thyroid levels in the presence of elevated insulin levels as
occurs with
obesity, insulin resistance, or type II
diabetes (91 - 99,233).
Acute inflammation
occurs over seconds, minutes, hours,
and days; for example swelling after an injury; while chronic inflammation
occurs over long periods of time
and is associated with chronic diseases such as
diabetes, heart disease
and obesity.
Under conditions of dysbiosis, the gut microbiota becomes perturbed
and, as a consequence, chronic inflammation
occurs, together with a plethora of metabolic
and immunogenic reactions that might contribute to the onset of
obesity, type 2
diabetes, metabolic syndrome,
and AD.»
This is sometimes referred to as physiological insulin resistance in order to distinguish it from the pathological insulin resistance that
occurs in Type 2
diabetes,
obesity,
and metabolic syndrome.
The diagnosis of metabolic syndrome, a precursor to type 2
diabetes,
occurs when a person has three out of five of the following disorders that affect metabolism: high blood pressure, high blood sugar, high triglycerides, low levels of good cholesterol
and abdominal
obesity.
We have an epidemic
occurring in the rate of chronic diseases, like
obesity,
diabetes, hypertension, asthma
and cancer.
Obesity and type 2
diabetes are
occurring at epidemic rates in the United States
and many parts of the world.
Suppression of melatonin by light at night results in circadian disruption
and has been implicated in sleep disturbances, increased risk for
diabetes and obesity, as well as increased risk for more serious diseases, such as breast cancer, if circadian disruption
occurs for many consecutive years, such as in night shift workers.
Suppression of melatonin by light at night results in circadian disruption
and has been implicated in sleep disturbances, increased risk for
diabetes and obesity, as well as increased risk for more serious diseases, such as breast cancer, if circadian disruption
occurs for many consecutive years, such as in nightshift workers.
The suppression of melatonin by light at night reading that results in circadian disruption has been implicated in sleep disturbances, an increased risk for
diabetes and obesity, as well as increased risk for more serious diseases, such as breast cancer, if circadian disruption
occurs for many consecutive years, such as in nightshirt workers.)
This decline
occurred at a time when there is a global epidemic of type 2
diabetes and metabolic syndrome, which includes
obesity, altered blood cholesterol levels, high blood pressure,
and increased blood glucose resulting from insulin resistance.
Regardless of the type
and severity of
diabetes, affected dogs should receive a proper dietetic therapy in order to correct
obesity (when present), maintain constant frequency
and caloric content of meals
and provide a diet which reduces blood glucose fluctuations
occurring shortly after eating.
Because of the marked increase in
obesity and physical inactivity in children (18), 30 % of new cases of human type 2
diabetes now
occur in people < 20 y of age.
They report that the trend is likely
occurring throughout the United States because the higher prevalence of risk factors such as
obesity and diabetes seen in the young here are also seen throughout the country.