This search for protective rather than risk factors is part of a paradigm shift in Joslin's
diabetes complications studies, says Dr. King, who also is Joslin's chief scientific officer and a professor of medicine at Harvard Medical School.
The nationwide cohort study surveyed participants in the Japan
Diabetes Complications Study who were between the ages of 40 and 70 and had been diagnosed with diabetes.
A second, unrelated study that analyzed data from a cohort of people with type 1 diabetes in the Pittsburgh area, the Pittsburgh Epidemiology of
Diabetes Complications study (EDC), showed why it is so important to recognize depressive symptoms in people living with diabetes: Those who exhibit the highest level of depressive symptoms are most likely to die prematurely.
Not exact matches
The
study found that there was no harm in advising women with
diabetes in pregnancy, at low risks of
complications, to express breastmilk from 36 weeks» gestation.
In both
studies, the link between OSA and the two
diabetes complications in people with Type 2
diabetes was independent of age, gender, ethnicity, blood pressure, blood glucose levels, smoking and cholesterol.
UKPDS - Implications for the care of people with Type 2
diabetes The United Kingdom Prospective Diabetes Study (UKPDS), the largest clinical research study of diabetes ever conducted, has provided conclusive evidence that the life threatening complications of Type 2 diabetes (non insulin dependent diabetes) can be significantly reduced by appropriate tr
diabetes The United Kingdom Prospective
Diabetes Study (UKPDS), the largest clinical research study of diabetes ever conducted, has provided conclusive evidence that the life threatening complications of Type 2 diabetes (non insulin dependent diabetes) can be significantly reduced by appropriate tr
Diabetes Study (UKPDS), the largest clinical research study of diabetes ever conducted, has provided conclusive evidence that the life threatening complications of Type 2 diabetes (non insulin dependent diabetes) can be significantly reduced by appropriate treat
Study (UKPDS), the largest clinical research
study of diabetes ever conducted, has provided conclusive evidence that the life threatening complications of Type 2 diabetes (non insulin dependent diabetes) can be significantly reduced by appropriate treat
study of
diabetes ever conducted, has provided conclusive evidence that the life threatening complications of Type 2 diabetes (non insulin dependent diabetes) can be significantly reduced by appropriate tr
diabetes ever conducted, has provided conclusive evidence that the life threatening
complications of Type 2
diabetes (non insulin dependent diabetes) can be significantly reduced by appropriate tr
diabetes (non insulin dependent
diabetes) can be significantly reduced by appropriate tr
diabetes) can be significantly reduced by appropriate treatment.
Studies have shown that
diabetes complications can be greatly reduced by measuring glucose levels several times a day to inform diet and medication decisions.
Many
studies have indicated that an increasing number of pregnant women in the U.S. have health conditions that could boost the risk of problematic
complications including chronic health disease, hypertension and
diabetes.
«In further
studies we want to examine how different combination therapies affect the retinal proteins, in order to achieve a better understanding of the causes and treatment of this
diabetes complication,» added Dr. Stefanie Hauck (PROT).
«If these improvements continue over time, they may result in a lower risk of heart disease,» said the
study's principal investigator, Carel Le Roux, MD, PhD,
Diabetes Complications Research Centre, University College Dublin.
«The next step is a much larger - scale
study, to look at the genetics and immune systems of people still making insulin, and to answer the important question of whether the
complications of Type 1
Diabetes are reduced in people with low levels of insulin.»
It suggests an opportunity to educate both patients and providers to decrease
complications and improve outcomes,» says senior
study author Megan R. Haymart, M.D., assistant professor of metabolism, endocrinology and
diabetes at Michigan Medicine.
New research published in Diabetologia (the journal of the European Association for the
Study of
Diabetes) shows that age (or age at diagnosis) and duration of diabetes disease are linked to the risk of death and marcovascular complications (those in larger blood vessels), whereas only diabetes duration is linked to the risk of microvascular complications (in smaller blood vessels such as those in th
Diabetes) shows that age (or age at diagnosis) and duration of
diabetes disease are linked to the risk of death and marcovascular complications (those in larger blood vessels), whereas only diabetes duration is linked to the risk of microvascular complications (in smaller blood vessels such as those in th
diabetes disease are linked to the risk of death and marcovascular
complications (those in larger blood vessels), whereas only
diabetes duration is linked to the risk of microvascular complications (in smaller blood vessels such as those in th
diabetes duration is linked to the risk of microvascular
complications (in smaller blood vessels such as those in the eyes).
The paper, published in the journal Diabetologia (the journal of the European Association for the
Study of
Diabetes), found for the first time that dementia - related complications within the brain can also lead to changes in glucose handling and ultimately d
Diabetes), found for the first time that dementia - related
complications within the brain can also lead to changes in glucose handling and ultimately
diabetesdiabetes.
«Although many guidelines recommend people with
diabetes reduce their salt intake to lower the risk of
complications, this
study is among the first large longitudinal
studies to demonstrate the benefits of a low - sodium diet in this population.»
«This is a very exciting finding, obtained by
studying patients» cells, that has the potential to result in a new treatment for this chronic
complication of longstanding Type 1
diabetes,» Dr. Folli said.
With the rate of
diabetes increasing dramatically worldwide, many individuals will be at risk for vision loss from diabetic eye
complications and DME is a major global health concern,» says Jennifer K. Sun, M.D., M.P.H., a member of the
study research team and writing committee, and an Investigator in the Section on Vascular Biology, an ophthalmologist in Beetham Eye Institute at Joslin and an Assistant Professor at Harvard Medical School.
«Other
studies have identified a connection between inflammation biomarkers and pregnancy
complications such as pre-eclampsia and gestational
diabetes,» Palomba said.
Study findings indicate that among older adults who had
diabetes for a shorter duration (9 years or less), nonfatal cardiovascular
complications had the highest incidence (coronary artery disease, congestive heart failure, and cerebrovascular disease), followed by diabetic eye disease and acute hypoglycemic events.
Cardiovascular
complications and hypoglycemia (low blood sugar) were common nonfatal
complications in adults 60 years of age and older with
diabetes, according to a
study published by JAMA Internal Medicine, a JAMA Network publication.
«The high burden of early
complications in youth with
diabetes requires additional research to clarify the underlying causes and to identify effective intervention strategies,» said Dr. Dana Dabelea, lead author and co-chair of the national SEARCH
Study and professor of epidemiology at the Colorado School of Public Health at the University of Colorado Anschutz Medical Campus.
The
study, from researchers involved with the nationwide SEARCH for Diabetes in Youth Study, looked at five health complications and co-morbidities of diabetes, including: retinopathy (eye disease), diabetic kidney disease, peripheral neuropathy (altered sensation in the feet), arterial stiffness and high blood pres
study, from researchers involved with the nationwide SEARCH for
Diabetes in Youth Study, looked at five health complications and co-morbidities of diabetes, including: retinopathy (eye disease), diabetic kidney disease, peripheral neuropathy (altered sensation in the feet), arterial stiffness and high blood p
Diabetes in Youth
Study, looked at five health complications and co-morbidities of diabetes, including: retinopathy (eye disease), diabetic kidney disease, peripheral neuropathy (altered sensation in the feet), arterial stiffness and high blood pres
Study, looked at five health
complications and co-morbidities of
diabetes, including: retinopathy (eye disease), diabetic kidney disease, peripheral neuropathy (altered sensation in the feet), arterial stiffness and high blood p
diabetes, including: retinopathy (eye disease), diabetic kidney disease, peripheral neuropathy (altered sensation in the feet), arterial stiffness and high blood pressure.
«We have walkable neighbourhoods in many towns and cities in Canada, but they have to actually be used to help us reduce our risks of developing chronic conditions like type 2
diabetes and its associated
complications,» says
study senior author, Dr. Kaberi Dasgupta, MUHC internal medicine physician and an associate professor of medicine at McGill University.
A new
study from McMaster and York universities has found that poor muscle health may be a
complication of Type 1
diabetes, even among active twenty - somethings.
The
study also found that the higher the dose of any of the statins, the greater the risk of
diabetes,
diabetes complications, and obesity.
As in prior
studies among older adults, we found that obesity was associated with a decreased risk of dementia, consistent with the hypothesis that, while obesity in mid-life may increase risk for later - life cognitive decline and dementia, obesity at older ages may be associated with cognitive and other health advantages.25 - 27 The trend toward a declining risk for dementia in the face of a large increase in the prevalence of
diabetes suggests that improvements in treatments between 2000 and 2012 may have decreased dementia risk, along with the documented declines in the incidence of common
diabetes - related
complications, such as heart attack, stroke, and amputations.11 Our finding of a significant decline between 2000 and 2012 of the heart disease - related OR for dementia would also be consistent with improved cardiovascular treatments leading to a decline in dementia risk.
In the
study, statin use was also associated with a «very high risk of
diabetes complications,» says Mansi.
Among 3,351 pairs of similar patients — part of the overall
study group — those patients on statins were 250 percent more likely than their non-statin-using counterparts to develop
diabetes with
complications.
The finding builds on an earlier surprise from the Joslin Medalist
Study program, which looks for clues on how some people live with type 1
diabetes for more than 50 years with unusually low levels of
complications, says George King, M.D., Joslin's Chief Scientific Officer and Professor of Medicine at Harvard Medical School.
But the new
study firmly establishes that some of these cells endure for many decades in some Medalists — offering clues to potential treatments for preserving and even restoring the crucial cell population, says George L. King, M.D., senior author on the paper, Joslin's chief scientific officer and head of the Dianne Nunnally Hoppes Laboratory for
Diabetes Complications.
I know the research faculty is looking forward to have Alex lead our efforts in the
study of gut microbiome on all aspects of
diabetes and its related
complications.
Natarajan has been at the forefront of research on the
complications of
diabetes and the first to
study epigenetic changes in diabetic vascular
complications and metabolic memory.
Researchers are building a database of DNA sequence, functional and epigenomic information, and clinical data from
studies on type 2
diabetes and its macro - and microvascular
complications, and creating analytic tools to analyze these data.
«We know that people with type 2
diabetes and insulin resistance are susceptible to atherosclerosis, but our
study shows that excess insulin alone does not promote this
complication.»
Children of these families tend to be extremely obese, and there has actually been
studies showing that if these children are treated with leptin or injected with leptin chronically over time, this resolves and significantly reduces the weight gain, and they become leaner and this prevents other
complications such as
diabetes that can develop.
«We are very eager to develop new treatments for diabetic kidney disease,» says George King, M.D., lead author of the
study, and chief scientific officer, head of the Dianne Nunnally Hoppes Laboratory for
Diabetes Complications and a professor of medicine at Harvard Medical School.
April 18, 2011 Elderly
diabetes patients with very low glucose levels have slightly increased risk of death A new
study of older
diabetes patients has found that well - controlled blood sugar levels were associated with a lower risk of major
complications such as heart attacks, amputation and kidney disease, but the very lowest blood sugar levels were associated with a small but significant increased risk of death.
«This would be a great way of avoiding many of the
complications associated with
diabetes,» said Jeff Millman, a co-author of the
study and a professor of medicine and biomedical engineering at Washington University.
However, this additional care was not linked to a drop in pregnancy - related
complications, such as high blood pressure, gestational
diabetes and overly large babies, the
study found.
A 2005
study from the American Association of Clinical Endocrinologists (AACE) involving more than 157,000 people with
diabetes found that more than two - thirds weren't adequately controlling their blood sugar, which put them at risk for blindness, kidney failure, foot amputation, and other
complications.
In the new
study, a research team led by David M. Nathan, MD, of Massachusetts General Hospital, in Boston, looked at results from three large, long - term
studies: the
Diabetes Control and
Complications Trial (DCCT); its follow - up
study, the Epidemiology of
Diabetes Interventions and
Complications (EDIC); and the Pittsburgh Epidemiology of
Diabetes Complications (EDC)
study.
A 2011
study in the Pakistan Journal of Biological Sciences by Mazloom et alfound that vitamin c supplementation «can decrease fasting and postprandial oxidative stress and may prevent
diabetes complication» (13).
In
diabetes,
studies have shown that people with higher levels of various pesticides, had higher hemoglobin A1c levels (a measure of long term glucose control) and more neurological
complications.
Epidemiological
studies support that people who are deficient in vitamin D have a higher risk for developing an immune - related condition like chronic infections, metabolic
complications such as type 1
diabetes, and autoimmune diseases (3).
One
study in diabetic rats also showed that intermittent fasting protected against kidney damage, one of the most severe
complications of
diabetes (13).
While benfotiamine may be a promising supplement for Alzheimer's disease,
diabetes complications, and other conditions involving advanced glycation end - products, not all
studies have shown benefits.
Epidemiological
studies suggest that individuals who have inadequate Vitamin D levels are at an increased likelihood to develop an immune - related disorder such as chronic infections, autoimmune diseases and metabolic
complications associated with type 1
diabetes.
Fresh fruit consumption in relation to incident
diabetes and diabetic vascular
complications: A 7 - y prospective
study of 0.5 million Chinese adults.
A 2001
study, for example, noted that AGEs cause «the
complications of
diabetes and aging,» with the AGEs particularly affecting things like collagen (which gives skin its firmness) and elastin (which helps skin bounce back after being stretched).
Molecular Aspects of Lipoic Acid in the Prevention of
Diabetes Complications Nutrition 2001 (Oct); 17 (10): 888 — 895 In experimental and clinical
studies, LA markedly reduced the symptoms of diabetic pathologies, including cataract formation, vascular damage, and polyneuropathy.