Not exact matches
Most importantly, these cells protected
mice from developing
diabetes in a
model of disease, having the critical ability to produce insulin
in response to changes
in glucose levels.
«We think that for the first time, we have a
mouse model of anorexia that closely resembles the conditions leading up to the
disease in humans,» said study leader Lori Zeltser, PhD, associate professor
of pathology & cell biology and a researcher
in the Naomi Berrie
Diabetes Center.
The two labs are now collaborating on further studies
of the new enzymes — and the potential benefits
of inhibiting them —
in mouse models of diabetes, inflammation and autoimmune
disease.
Using red blood cells modified to carry
disease - specific antigens, a team
of scientists from Whitehead Institute and Boston Children's Hospital have prevented and alleviated two autoimmune
diseases — multiple sclerosis (MS) and type 1
diabetes —
in early stage
mouse models.
This proposed role for GM1 (and indirectly GD1a) provides a rationale for its potency
in suppressing
diabetes in NOD
mice (10) and
disease onset
in other animal
models of autoimmunity.