Sentences with phrase «diabetic mice with»

So Belmonte's group infected diabetic mice with viruses carrying the dead guide activators.

Not exact matches

Yu and his research team discovered that in the diabetic mouse cornea, the density of sensory nerve fibers and their endings are drastically reduced, similar to patients with DPN.

But with this approach, the team simply applied the lotion to diabetic mice's sores.

They compared the concentrations of proteins in the retinas of non-diabetic mice, of mice with type 2 diabetes without treatment and of type 2 diabetic mice that were treated with the standard drug metformin, which lowers blood glucose levels and thus reduces diabetes complications.

They demonstrated that non-obese diabetic (NOD) mice treated with a specific (AID / RAD51) pathway inhibitor had larger populations of certain B cells that were capable of suppressing diabetogenic T cell responses, and greatly reduced T1D development, compared with untreated controls.

When the team transplanted the cells into diabetic mice whose own beta cells had been destroyed artificially with a chemical, the cells acted like healthy beta cells.

The drug, SRT1720, kept mice with high - calorie diets from becoming obese or diabetic, according to a study published in Cell Metabolism [subscription required].

In their experiments involving mice with diabetic wounds, a wound was shown to heal stronger and thrice as fast with the application of ANGPTL4.

To turn this into something that could one day be a viable therapy for people, the team took stomach stem cells from diabetic mice, engineered them with the same genes and grew mini-organs.

One of the most popular models is the immunodeficient nonobese diabetic severe combined immunodeficiency (NOD scid) gamma (NSG) transgenic mouse line, which can be endowed with a humanized immune system using CD34 + hematopoietic stem cells.

The mutant mice produced less insulin — the hormone made in the pancreas that helps cells burn sugar — and they were plump and diabetic, with high levels of glucose in their blood.

In these two microscopy images, human islets (the source of insulin cells) were poisoned with a drug to remove the insulin cells, and then treated with either an empty virus (left panel) or the therapeutic virus (right panel), and then grown in a diabetic mouse.

In addition, the researchers conducted an experiment in the Type I diabetic mice using modified insulin and nanoparticles that had been coated with red blood cell membranes.

Cells equipped with a gene whose activity is driven by blue light were used to help diabetic mice control glucose levels.

In fact, the speed and kinetics of touching down to safe blood glucose levels are identical in diabetic mouse models treated with Ins - PBA - F and in healthy mice whose blood sugar is regulated by their own insulin.

(A) Isolated islets from 3 - wk - old, female, Tg - hIAPP mice were cultured in presence of different concentrations of islet extracts (IE) from old Tg - hIAPP mice, with overt diabetic pathology and age - matched WT mice.

Scientists report in the May 9 Science Translational Medicine that seven of 12 diabetic mice treated with this combination were cured even after having lost the ability to make insulin for several weeks, the equivalent of a human patient who has needed insulin injections for a couple of years.

Groups of male, IAPP, Tg mice were injected i.p. at 4 wk of age with 10 % pancreas homogenate from male, diabetic, IAPP Tg mice or 50 µM IAPP aggregates prepared from synthetic source.

To rule out that the induction observed was due to other diabetic - associated alterations in the pancreas, we performed a control experiment in which we injected Tg - hIAPP mice with pancreas homogenate from a diabetic model not associated with IAPP aggregation.

As shown in Fig. 2 A, treatment with 1 % islet homogenate from diabetic mice leads to punctated accumulation of thioflavin S (ThS)-- positive amyloid aggregates in cultured islets.

The results demonstrated that this new molecule was safe and effective, causing significant improvement in mouse models of both acute uveitis and chronic diabetic inflammation, with no apparent side - effects.

To further validate our result in clinical samples, we obtained primary tumor from patients with advanced breast cancer and the tissue was passaged once in nonobese diabetic / severe combined immunodeficient mouse without in vitro culture.

No significant difference in body weight was observed in the groups treated with diabetic pancreas homogenate, containing IAPP aggregates or synthetic IAPP aggregates, prepared in vitro, compared with Tg - hIAPP mice injected with buffer (Fig. 8 A).

In people with diabetes, beta cells don't function well, but Melton and his team were able to use the new beta cells to improve the glucose state of diabetic mice.

Inhibition of dipeptidyl peptidase IV with sitagliptin (MK0431) prolongs islet graft survival in streptozotocin - induced diabetic mice.

(a) Growth curves of primary tumors in non-obese diabetic / severe combined immunodeficiency disease (NOD / SCID) mice injected with 5 × 105 or 5 × 104 MDA - MB 231 and MDA - MB 231 F3 cells.

Creation of a rich subcutaneous vascular network with implanted adipose tissue - derived stromal cells and adipose tissue enhances subcutaneous grafting of islets in diabetic mice.

Oral chronic gavage with galanin in diabetic mice increases insulin sensitivity, which is associated with an improvement of several metabolic parameters such as glucose tolerance, fasting blood glucose, and insulin.

Paternal effect on embryo quality in diabetic mice is related to poor sperm quality and associated with decreased glucose transporter expression

The study showed that fisetin, a flavonoid contained in abundance in strawberries, promoted survival of neurons grown in culture and enhanced memory in healthy mice, along with prevention of both kidney and brain complications in diabetic mice.

Meditation delays molecular aging 12.06.2012 Lower your heart rate and live longer 22.05.2012 Just 15 minutes» walking per day extends life expectancy 14.05.2012 Contented men live longer, contented women don't 29.04.2012 Survival tip: eat chicken instead of beef 23.04.2012 Contented people live longer 22.04.2012 Walking, not running, delays cell aging 05.04.2012 Stay fit and untroubled by negative feelings for a long life 04.04.2012 Grow old healthily with green tea 11.03.2012 Watching TV is soooo bad for you 29.02.2012 Live longer with monounsaturated fatty acids 22.02.2012 Exercise delays aging as much as caloric restriction does 02.02.2012 Get fit, delay aging 30.01.2012 How beta - alanine can extend your life expectancy 27.01.2012 Being fit protects your cells from rusting 26.01.2012 High blood sugar level makes you look older 22.01.2012 Optimists live longer 24.12.2011 Yoga makes diabetics healthier 29.11.2011 Belief in a just world extends life expectancy 27.11.2011 Sleep better — live longer 25.11.2011 Forgive and live longer 28.10.2011 Probiotic bacteria LKM512 extends lifespan in animal study 24.10.2011 Animal study: Royal Jelly has life extending properties 18.10.2011 L - Arginine: «the best anti-aging remedy» 02.10.2011 Test - tube study: ashwagandha inhibits Alzheimer's 10.08.2011 Live longer — take carnosine 04.08.2011 Creatine - Q10 combination protects brain cells and lengthens lifespan: animal study 15.07.2011 Fish oil helps aging mice live longer 02.07.2011 Hard workers live longer 12.06.2011 Supercentenarians are extremely healthy 06.06.2011 Why sculptors live longer than painters 03.06.2011 Afternoon nap helps you live longer 01.06.2011 Calorie burning reduces mortality in elderly 17.05.2011 Eat more beans and live longer 11.05.2011 Raise your VO2max to delay ageing 18.04.2011 Lithium in drinking water helps you live longer 16.04.2011 Nonagenarians with resilience will make it to 100 14.04.2011 Royal Jelly rejuvenates pituitary: animal study 02.04.2011 Four healthy habits can prolong your life by fourteen years 19.03.2011 The rejuvenating effect of 45 minutes» running every day: animal study 28.01.2011 So vitamin E does extend life expectancy... 27.11.2010 Carnosine extends lifespan in animal study 10.11.2010 BCAAs extend lifespan in animal study 28.10.2010 Elderly are fitter with Cordyceps sinensis 08.10.2010 Glucosamine and chondroitin users live longer 24.06.2010 Rhodiola rosea extends life in animal study 18.06.2010 Runners» testes stay young 10.06.2010 Drink green tea instead of water — and live longer 24.05.2010 Low - carb diet delays aging and promotes health 19.05.2010 Q10 makes worms live longer 09.05.2010 Diet of coffee, nuts and berries keeps you healthy 26.04.2010 Delay aging without hunger with life extenders in green apples 19.04.2010 Endogenous growth hormone keeps older athletes young 09.04.2010 Men who take ginseng live longer 19.03.2010 Animal study: Canadian longevity stacker works 05.03.2010 Human study: omega - 3 fatty acids delay molecular ageing 08.02.2010 Fish oil lengthens life in animal study 07.02.2010 Curious?

Moreover, it should be noted that ketogenic diets are only relatively high in protein18, 106 and that some recent studies have demonstrated that VLCKD can even cause a regression of diabetic nephropathy in mice.109 With regard to possible acidosis during VLCKD, as the concentration of KBs never rises above 8 mmol / l10 this risk is virtually inexistent in subjects with normal insulin functWith regard to possible acidosis during VLCKD, as the concentration of KBs never rises above 8 mmol / l10 this risk is virtually inexistent in subjects with normal insulin functwith normal insulin function.