"Diabetic rats" refers to rats that have a medical condition called diabetes.
Full definition
One study
in diabetic rats also showed that intermittent fasting protected against kidney damage, one of the most severe complications of diabetes (13).
As the researchers wrote in the journal, «Diabetes,» tests
on diabetic rats showed that repeated treatments with the drug led to increasingly improved nerve function.
According to one study
in diabetic rats, avocado oil can protect against the harmful effects of free radicals by entering the mitochondria (26).
Interestingly, it has recently been shown that memantine, an uncompetitive NMDA receptor antagonist that inhibits overactivity of NMDARs, was able to prevent retinal ganglion cell degeneration in streptozotocin -
induced diabetic rats [73].
In an animal study, we previously showed that caffeine consumption improved the erectile function
of diabetic rats by up - regulating cavernous cGMP [20].
In
diabetic rat models, female mesenteric arteries show greater abnormal vascular responses demonstrated by greater impairment of acetycholin - induced relaxation and an increased expression of endothelial nitric oxide synthase.
Antidiabetic effect of flax and pumpkin seed mixture powder: effect on hyperlipidemia and antioxidant status in
alloxan diabetic rats.
In «Diabetic rats cured with their own stem cells ``, we report how researchers cured
diabetic rats by turning brain stem cells extracted through the nose into insulin - producing cells in the pancreas.
In view of their most recent results, it seems the key lies in the fact that chronic melatonin consumption not only induces the appearance of «beige fat» in
obese diabetic rats, but also increases its presence in thin animals used as a control group.
In this study, the authors examined the effects of sex hormones on systematic and renal hemodynamic parameters, mean arterial pressure, renal cortical flow and renal medullary blood flow in castrated male and spayed
female diabetic rats, compared with sham - operated animals.
Sex hormone regulation of systemic endothelial and renal microvascular reactivity in type - 2 diabetes: studies in gonadectomized and sham - operated Zucker diabetic rats
Streptozotocin -
diabetic rats express deficits in water maze learning and hippocampal synaptic plasticity.
In addition, the study was able to show that it protected blood vessels of
diabetic rats against oxidative chemicals and hardening of the arteries.
In fact, a study looking
at diabetic rats given cumin extract revealed that cumin was more effective at reducing blood glucose and AGE production than glibenclamide, an anti-diabetic drug.
These studies include a report published in the journal Andrologia in 2012, in which tests on
diabetic rats determined that Butea superba may help improve erectile function by stimulating circulation.
Because diabetics are at high risk of having neuropathic pain, the team
studied diabetic rats that had neuropathic symptoms: hypersensitivity to touch and lack of heat sensation.
Research published in the Journal of Agricultural and Food Chemistry found that buckwheat extract lowered blood glucose levels by 12 to 19 percent when added to the diets
of diabetic rats.
A result of the study of effects of Aloe Vera on
diabetic rat models suggests that it is useful in the treatment of diabetes.
Antidiabetic effect of flax and pumpkin seed mixture powder: effect on hyperlipidemia and antioxidant status in
alloxan diabetic rats.
Rubino bases his hypothesis on a series of experiments he did in 2004
on diabetic rats.
Recently the European Journal of Pharmacology published research that discovered curcumin naturally activates the opioid system
in diabetic rats.
In one investigation,
diabetic rats treated with coconut water kept up preferred glucose levels over other diabetic rats (9).
These findings suggest that disrupted MCT2 - mediated uptake of lactate by neurons contributes to memory dysfunction in type 2
diabetic rats.
«We showed for the first time that glycogen levels are significantly higher in the hippocampus of
diabetic rats,» corresponding author Hideaki Soya says.
«MCT2 expression was significantly lower in the hippocampus of type 2
diabetic rats,» Soya says, «dysregulated MCT2 - mediated neuronal uptake of lactate is a possible aetiology of memory dysfunction in type 2 diabetes, and that elevated hippocampal glycogen may be an adaptive change to compensate for the decreased lactate utilization.»
«This indicated that exercise significantly improved spatial memory impairments in type 2
diabetic rats,» Shima explains.
The most promising chemical — sulforaphane, a naturally occurring compound found in cruciferous vegetables — tamped down glucose production by liver cells growing in culture, and shifted liver gene expression away from a diseased state in
diabetic rats.
4 weeks of moderate exercise further enhanced glycogen levels and normalized MCT2 expression in the hippocampus of type 2
diabetic rats.»
In the intestines of
diabetic rats, they found that GLP - 1 triggered some gut cells to become more like those that manufacture insulin in the pancreas.
Zambidis says there are plans to conduct additional experiments of their cells in
diabetic rats, whose conditions more closely resemble human vascular damage to the retina than the mouse model used for the current study, he says.
Then, the team evaluated which genes were turned on or off in diaphragm arteries in
the diabetic rats during exercise training.
They found that certain types of glucose transporters (GLUT and SGLT) as well as their regulatory proteins were present in a higher number in type 2
diabetic rats.
Among their additional work in animal models, the scientists showed that
diabetic rats that received human DME fluid high in PKal - related proteins but low in VEGF developed increased leakage from retinal blood vessels.
French researchers found that
diabetic rats on a high protein diet with arginine and proline — specific molecules found in protein — showed better wound healing over rats fed either standard or high protein food without arginine and proline supplementation.
Sex differences in mesenteric endothelial function of streptozotocin - induced
diabetic rats: a shift in the relative importance of EDRFs
Place learning and hippocampal synaptic plasticity in streptozotocin - induced
diabetic rats.
Water maze learning and hippocampal synaptic plasticity in streptozotocin -
diabetic rats: effects of insulin treatment.
In sciatic nerves of streptozotocin (STZ)- induced
diabetic rats, motor and sensory nerve conduction velocities (NCVs) and capillary density were reduced, and axonal atrophy and demyelination were observed.