Sentences with phrase «diabetic subjects»

In addition, a recent metaanalysis showed that the relative risk of myocardial infarction (MI), an important and frequent complication in diabetic subjects, conferred by smoking appears to be 25 % higher in women than in men (138).

Thus, it is unclear whether human satellite cells established from diabetic subjects express traits found in in vivo biopsies, such as reduced FV.

Blood glucose and insulin responses to different meals in non-insulin-dependent diabetic subjects of both sexes

However, in obese diabetic subjects, insulin stimulates the FV of GS to a lower extent (6).

In newly diagnosed diabetic subjects without clinical CVD, increased atherosclerosis and higher intima media thickness was found in carotid arteries (271).

Myotubes established from type 2 diabetic subjects express a reduced GS mRNA and protein compared with control subjects (5).

Kar P, Laight D, Rooprai HK, Shaw KM, Cummings M. Effects of grape seed extract in Type 2 diabetic subjects at high cardiovascular risk: a double blind randomized placebo controlled trial examining metabolic markers, vascular tone, inflammation, oxidative stress and insulin sensitivity.

Influence of parboiling and physicochemical characteristics of rice on the glycaemic index in non-insulin dependent diabetic subjects

Previous studies of cell cultures from diabetic subjects cultured under basal physiological conditions showed that the basal as well as the insulin - stimulated FV0.1 values are reduced (4,5).

Sex seems to influence glucose utilization in obese and diabetic subjects substantially (293, 294).

ΔA0.5 is lower for the diabetic group than the control group, but this difference disappears because ΔA0.5 in cultures established from type 2 diabetic subjects significantly increased with increasing insulin concentration.

In this study, we compared a group of «supernormal» young lean subjects with the most common form of type 2 diabetes in obese elderly diabetic subjects in order to optimize our conditions for finding significant differences.

They also observed significant decreases in total cholesterol and triglyceride values in both normal and diabetic subjects given either 2 grams per day or 3 grams per day.

Efficacy of Ipomoea batatas (Caiapo) on diabetes control in Type 2 diabetic subjects treated with diet.

According to research conducted by the Agricultural Research Service diabetic subjects who consumed less that half a teaspoon of cinnamon per day had significantly reduced blood sugar levels.

Previous studies of cell cultures established from diabetic subjects and cultured under basal physiological conditions showed that the basal as well as the insulin - stimulated FV values are reduced (4,5).

Influence of the amount of starch on the glycaemic index to rice in non-insulin-dependent diabetic subjects

In collaboration with colleagues from the Harvard School of Public Health and research institutes in Italy, they conducted genome - wide association analyses of 1,517 type 2 diabetic patients with CHD and 2,671 type 2 diabetic subjects without CHD.

To identify the rate - limiting step for glycogen synthesis in type 2 diabetic subjects compared with control subjects, the experimental system has to include at least two conditions: 1) similar extracellular conditions under which glucose transport / phosphorylation can be studied and 2) identical glucose uptake fluxes, which will allow the identification of downstream defects.

Diabetic Medicine, May 2009, 26 (5): 526ï ¿ 1/2 531, «Effects of grape seed extract in Type 2 diabetic subjects at high cardiovascular risk: a double blind randomized placebo controlled trial examining metabolic markers, vascular tone, inflammation, oxidative stress and insulin sensitivity»

Anxiety and eating disorders as well as depression are more common in diabetic subjects, especially in women (Table 3)(338).

It also synced with production of beige fat in obese diabetic subjects.

Ludvik B, Hanefeld M, and Pacini G. Improved metabolic control by Ipomoea batatas (Caiapo) is associated with increased adiponectin and decreased fibrinogen levels in type 2 diabetic subjects.

Joslin scientists are currently investigating whether there are other genetic variants that specifically predispose type 2 diabetic subjects to cardiovascular disease and are planning to expand this research to investigate genetic variants associated with CHD in the type 1 diabetes population.

Furthermore, it is unclear whether the glucose uptake is primarily affected in cultures established from type 2 diabetic subjects.

Among younger normal - weight sedentary volunteers (217) and also in obese and diabetic subjects (218), females had higher IMCL in leg muscle (219), higher lipid area density, and greater number of IMCL droplets than males.

In this study, we have shown evidence that skeletal muscle cells established from type 2 diabetic subjects, grown and fused under basal physiological culture conditions, retain defects in insulin - stimulated GS activity, indicating that the insulin - resistant phenotype is intrinsic to the cells.

On the other hand, an inverse correlation between plasma adiponectin levels and insulin sensitivity is seen in obese and diabetic subjects, which tends to be somewhat more pronounced in women (45 — 47).

More than half of the diabetic subjects are middle aged, and incidence rises with increasing ages in both sexes, reaching highest rates in the very old women (Figure 2B).

The present study shows that the diabetic phenotype can be conserved in human satellite cell cultures established from type 2 diabetic subjects and demonstrates that glucose uptake as well as insulin - stimulated GS activity is primarily affected in satellite cell cultures established from patients with type 2 diabetes.

Both glucose transport and glycogen synthesis are stimulated by insulin, and defects in both processes have been postulated to take part in the development of insulin resistance in type 2 diabetic subjects in vivo.

As a new finding, we describe here that impaired GS activity in cell cultures established from type 2 diabetic subjects can be compensated for by increasing insulin concentrations in a dose - dependent manner.

B: Cell cultures established from diabetic subjects.

Comparing basal and insulin - stimulated GS activity between cultures exposed to different insulin concentrations did not reveal significant differences in control cultures or those established from type 2 diabetic subjects (P > 0.05).

The question is: Do cell cultures, established from diabetic subjects, conserve the diabetic phenotype in culture?

a, P < 0.05; C, cultures established from control subjects; DM, cultures established from diabetic subjects.

The glycogen content was significantly negatively correlated to the basal FV0.1 (r = − 0.33, P = 0.01) and stimulated FV0.1 (r = − 0.27, P = 0.04) in cultures established from control subjects, and it was significantly positively correlated to the basal FV0.1 (r = 0.29, P = 0.02) and stimulated FV0.1 (r = 0.27, P = 0.02) in cultures established from diabetic subjects.

To get further insight into the differences between diabetic and control cultures, we compared the absolute differences between the basal and the insulin - stimulated state (ΔFV0.1) in control cultures and in those established from type 2 diabetic subjects (Fig. 3C).

The Hill coefficient was ∼ 1.0 for all culture conditions and did not vary with acute or chronic insulin stimulation in either control cultures or cultures established from diabetic subjects (P > 0.05, data not shown).

However, in diabetic subjects, this protection is alleviated.

Furthermore, presence of depression doubles mortality risk in diabetic subjects (339).

To overcome this limitation, a team led by JAX Assistant Professor Michael Stitzel, Ph.D., isolated single cells from the pancreatic islets of both non-diabetic and type 2 diabetic subjects to obtain transcriptomes for each cell.

Five studies on cinnamon and diabetic subjects and 3 on non-diabetic subjects were all analysed.

Metabolic response to cottage cheese or egg white protein, with or without glucose in type 2 diabetic subjects

Ludvik B, Hanefeld M, Pacini G. Improved metabolic control by Ipomoea batatas (Caiapo) is associated with increased adiponectin and decreased fibrinogen levels in type 2 diabetic subjects.

However, this increase is substantial in IGT and type 2 diabetic subjects, suggesting that metabolic endotoxinemia is exacerbated after high - fat intake.

Influence of ripeness of banana on the blood glucose and insulin response in type 2 diabetic subjects