While we still do not know just how Alzheimer's progresses or what role the fibrils play, they are always found in Alzheimer's - ridden brains and are considered
diagnostic markers of the disease.
Not exact matches
The company wanted to use it as a
diagnostic marker for
disease: If synthetic versions
of antibodies could be tagged with aequorin in the lab, then whenever they matched up with an antigen (or surface protein)
of a specific pathogen in blood or tissue, the sample would glow.
The goal is to identify new
disease diagnostic markers and develop new therapies, according to the company's head
of R&D in China, Andreas Tschirky, and chief scientific officer Li Chen.
A detailed understanding
of how TSPO binds to such
markers opens up novel paths for
diagnostic imaging and could constitute an important step along the way to early detection
of such
diseases and inflammations.
Monitoring the levels
of GARP on B cells may provide a very useful
diagnostic marker for autoimmune
disease.
A type
of antifungal antibody, called ASCA, is widely used as a
diagnostic marker since it is highly elevated in the blood
of patients with several chronic
diseases including Crohn's.
At present, the most common, sporadic form
of Alzheimer's
disease is difficult to diagnose until symptoms are readily apparent and significant damage to the brain has occurred; findings from this study may provide clues to suitable
diagnostic markers.
Gata5 a potential
diagnostic marker for congenital heart
disease The finding also suggests that gata5 could be a potential new
diagnostic marker for congenital heart defects, as the researchers demonstrated that gata5 regulates the expression
of a gene known as nkx2.5 which, when mutated in humans, causes human congenital heart defects and
disease.
The lack
of specific
markers of disease and the fact that the CFS diagnosis is controversial imply that the level
of diagnostic accuracy and adherence to international criteria are likely to be variable.
As
markers flanking and successively closer to the
disease gene are identified, the accuracy
of a
diagnostic linkage test is improved, but even relatively distant
markers give some predictive information.
Various types
of linkage tests have been most successful for identifying genetic
markers located close enough to
disease genes to be useful in
diagnostic tests.