Only a few studies on treating
diarrheal signs in dogs with tylosin have been published.
Even so, the effect of controlling
diarrheal signs does not appear to diminish with time, and thus there is no need to increase the dosage of the medication.
The dogs had shown chronic or intermittent
diarrheal signs for a period of more than one year.
If
diarrheal signs continue, tylosin treatment is re-initiated.
Since tylosin is an antimicrobial agent, it has been speculated that some pathogenic bacteria are likely responsible for
the diarrheal signs.
The mode of action must differ, however, from the immunomodulatory effect of prednisone because prednisone treatment did not completely resolve
diarrheal signs in the same dogs that responded to tylosin.
Based on negative culture results and ELISA tests, we have excluded such common enteropathogenic bacteria as Clostridium perfringens, Clostridium difficle, Salmonella spp., Campylobacter spp., and Yersinia spp. as causative factors for
the diarrheal signs occurring in TRD.
In contrast, prednisone did not completely resolve
diarrheal signs, and the probiotic Lactobacillus rhamnosus GG did not prevent the relapse of diarrhea in any of the dogs.