Sentences with word «dicer»

(2014) A variety of Dicer substrates in human and C.elegans.

Dr. Kahn and Joslin researchers are planning to investigate whether Rapamycin increases Dicer in cellular models.

One possible agent that might increase Dicer levels is Rapamycin, an immunosuppressant used to prevent rejection in organ transplantation.

For example, they discovered that ADAR1 forms a complex with Dicer to play a major role in the control of RNA interference mechanism.

Analysis of nearly one thousand mammalian mirtrons reveals novel features of Dicer substrates and miRNA evolution.

Fusion Tech Dicer Wash Walls come with a number of design and sanitation features that add value to your facility and processing operation.

The pathologist of the Department of Pathology at the University Hospital of Bellvitge August Vidal explained that «this tumorigenic transformation depends on Dicer protein that could serve as a marker for the presence of tumor cells, or as a therapeutic target.»

Together, these findings indicate an essential role for Dicer and miRNA processing in white and brown cell differentiation and whole body metabolism that may contribute to the development of HIV - related lipodystrophy.

Interestingly, suppression of Dicer activities is reported to result in promotion of epithelial - mesenchymal transistion and metastatic transformation of cancer cells.

The table below outlines those various features so you can choose the right slicer or dicer at a glance.

In plants and Caenorhabditis elegans, two distinct populations of small RNAs have been proposed to participate in RNAi: «Primary siRNAs» (derived from DICER nuclease - mediated cleavage of the original trigger) and «secondary siRNAs» [additional small RNAs whose synthesis requires an RNA - directed RNA polymerase (RdRP)-RSB-.

One of our discoveries is that dsRNAs that are long enough to be processed by the RNAi machinery, but short enough not to activate the interferon pathway, called Dicer substrate siRNAs, have enhanced potency and duration of action relative to the 21 base long siRNAs used in most studies.

Functional Redundancy of DICER Cofactors TARBP2 and PRKRA During Murine Embryogenesis Does Not Involve miRNA Biogenesis

We are supporting research projects with new fast transgenic mouse technology employing TAL effector nucleases — read more in Flemr M, Malik R, Franke V, Nejepinska J, Sedlacek R, Vlahovicek K, Svoboda P: A Retrotransposon - Driven Dicer Isoform Directs Endogenous Small Interfering RNA Production in Mouse Oocytes.

Fareh, Yeom, Haagsma, Chauhan, Heo, Joo «TRBP ensures efficient Dicer processing of precursor microRNA in RNA - crowded environments» Nature Communications, (2016)

Dicer recognizes double - stranded RNA (dsRNA), latches onto it, and chops it into pieces 21 - 23 nucleotides long.

I know it sounds like a late - night TV offer, with a vegetable dicer thrown in for free, but one of the most exciting areas of aging research is on the importance of the length of the tips of your chromosomes, called telomeres.

That's just how long it took me to wash and chop up the onion, bell peppers and carrots (I'm kinda a slow dicer).

The setup is over quicker than you can say «I know kung fu,» and from there on you it's on par with the first «Raid» film: non-stop, brutal and flat - out cool action, shot more like golden era John McTiernan than modern day slice - and - dicers like Michael Bay or Paul Greengrass.

Raw power and speed aren't new for modern Corvettes; true, the C5 and C6 were capable corner dicers, as well as drag racers, but could leave even the most experienced drivers» hairs standing on end near the limit, exhibiting a frightful tendency toward trailing - throttle oversteer.

Scientists find a new role for RNAi protein Dicer in preventing collisions during DNA replication...

Conserved vertebrate mir - 451 provides a platform for Dicer - independent, Ago2 - mediated miRNA biogenesis.

«If we could increase Dicer activity, fat tissue would have a healthier metabolism which would improve the metabolism of people being treated.

Recent studies revealed that loss of Dicer function to process Alu RNAs to small fragmented RNAs (Alu - siRNAs) underlie the AMD pathology.

Sharp knives, dicers, and graters can take the «labor» out of chopping & prepping veggies!

FoodSwing has spent in excess of $ 22 million automating a stainless steel fortress of cookers, tanks, dicers, pureeing machines, blending, liquefying and milling equipment — all just to prepare for the aseptic processing and filling operation.

Fusion Tech Dicer Wash Walls are designed to provide a quick and easy way to thoroughly clean the removable components of a meat dicer.

We even put our slicers and dicers to the test handling jerky, bacon bits, and meat snacks in these videos to show you how great our slicers truly are.

According to the head of the research group of chemoresistance and Predictors of tumor response and stromal environment ICO - IDIBELL, Alberto Villanueva, «tumor exosomes contain certain proteins (Dicer, TRBP and Ago2) able to process microRNAs that can alter the around the tumor cells transforming them into tumoral cells.»

Using a mouse model in which expression of Dicer was specifically knocked out in fat tissue, the researchers found that mice that lacked Dicer in fat developed abnormal fat distribution resembling HIV - related lipodystrophy (which is associated with antiviral treatment).

This research suggests that therapy with an agent that increases levels of Dicer or specific miRNA expression could be beneficial to people with metabolic syndrome.

The researchers also found lower Dicer levels in the fat tissue of patients with HIV and HIV - related lipodystrophy, suggesting that low levels of Dicer expression in fat in HIV patients may contribute to the development of this syndrome, a complication which limits therapy in some people with HIV.

Dicer - related therapy might also help patients with HIV - related lipodystrophy.

Earlier Joslin research revealed that with aging, miRNA processing in fat tissue decreases due to a decrease in Dicer, a critical enzyme that converts pre-miRNAs to mature miRNAs.

«It's good to build on our previous research on miRNA processing and Dicer in aging and find that a decline in Dicer may also play an important role in HIV lipodystrophy by dramatically changing the biology of fat and the tendency towards diabetes and metabolic syndrome,» says lead author C. Ronald Kahn, MD, Chief Academic Officer at Joslin Diabetes Center and the Mary K. Iacocca Professor of Medicine at Harvard Medical School.

With a helping hand from proteins RISC and DICER (scissors), small RNAs are born.

On - going research of the Nishikura laboratory is to examine whether the Dicer promoting function of ADAR1 has any relevance to AMD.

The laboratory has shown that ADAR1 forms a complex with Dicer and promotes its catalytic activity, increasing Dicer cleavage of pre-miRNA, RISC assembly, and loading of miRNA.

These studies indicate that ADAR1 is required for promotion of rapid increase of miRNA synthesis during embryogenesis, when the expression of TRBP, a canonical partner of Dicer, remains low.

In ADAR1 - null embryos, the lack of formation of the Dicer - ADAR1 complex results in dysregulated expression of many genes involved in cell death, cell proliferation, and organogenesis, which is likely to contribute at least in part to their embryonic lethality.

Most importantly, miR - BART6 silences Dicer through multiple target sites located in the 3 «UTR of Dicer mRNA.

Biogenesis of all microRNAs is regulated by two major components, Microprocessor and Dicer.

Re-evaluation of the roles of DROSHA, Export in 5, and DICER in microRNA biogenesis.

The 5p and 3p reads are offset by 2 nucleotides on both ends due to the sequential processing of the miRNA transcript by Drosha and Dicer to generate the mature ~ 22 nucleotide read (s).

The length of the loop is at least 8 nucleotides long; there is no apparent maximum in loop length, even in organisms possessing only a single Dicer gene, contra (6), even though most taxa like vertebrates with single Dicer genes never show loop lengths greater than ~ 40 nucleotides.

RNAi depends on two proteins, Dicer and Argonaute.