Sentences with phrase «diet of obese mice»

Surprisingly, the effects of obesity on gut bacteria, inflammation, and osteoarthritis were completely prevented when the high fat diet of obese mice was supplemented with a common prebiotic, called oligofructose.

Not exact matches

In a study published in the journal Food Chemistry in 2014, a team of researchers analyzed how the bioactive compounds of seven different varieties of apples - Granny Smith, Braeburn, Fuji, Gala, Golden Delicious, McIntosh and Red Delicious - affected the good gut bacteria of diet - induced obese mice.

Handa, T., Yamaguchi, K., Sono, Y., and Yazawa, K. Effects of fenugreek seed extract in obese mice fed a high - fat diet.

BYE BYE BUDS Mice that became obese on a high - fat diet (right) lost a quarter of their taste buds (stained red) and also had fewer progenitor cells (stained green)-- which give rise to new taste buds — than mice of a healthy weight on a regular diet (leMice that became obese on a high - fat diet (right) lost a quarter of their taste buds (stained red) and also had fewer progenitor cells (stained green)-- which give rise to new taste buds — than mice of a healthy weight on a regular diet (lemice of a healthy weight on a regular diet (left).

«Importantly, we found that blocking the actions of the endocannabinoids with pharmacological inhibitors of cannabinoid receptors in the periphery completely normalized food intake and meal patterns in western diet - induced obese mice to levels found in control lean mice fed standard chow.»

«We did not do it using a genetic strain of obese mice, but mice that became obese the way that people do, by eating a high - fat, high - sugar diet.»

Research conducted at the University of Barcelona showed that obese mice living on a diet enriched with omega - 3s displayed improved sensitivity to insulin.

To explore that question, a team led by Cornell University biomedical engineer Claudia Fischbach first showed that female mice that were obese, because of genetics or a high - fat diet, had more fibrous mammary fat pads with straighter collagen fibers than those seen in lean mice (see image).

We examined six experimental groups of 20 - week - old C57BL / 6J mice: (a) lean C57BL / 6J female mice, (b) lean C57BL / 6J male mice, (c) moderately obese C57BL / 6J male mice with diet - induced obesity, (d) moderately obese female B6.Cg Ay / + mice, (e) severely obese female B6.V Lepob / ob mice, and (f) severely obese male B6.V Lepob / ob mice.

We calculated the average adipocyte cross-sectional area and the percentage of F4 / 80 - expressing cells in the perigonadal, perirenal, mesenteric, and subcutaneous inguinal adipose tissue depots from Ay / + female, Lepob / ob female, lean male, and diet - induced obese (DIO) male mice.

In our previous study we found that a high fat diet containing comparable amounts of soybean oil to what Americans are currently consuming caused mice to become obese, diabetic and insulin resistant and to have large lipid droplets and hepatocyte ballooning in their livers.

Just 12 weeks of the high fat diet made mice obese and diabetic, nearly doubling their body fat percentage compared to mice fed a low fat, healthy diet.

The results of this initial study, and the description of the use of these two diets are presented in the paper by (4) Van Heek et al (1997), «Diet induced obese mice develop peripheral, but not central resistance to leptin».

The study found that feeding obese, pre-diabetic mice a specialized diet low in the amino acids leucine, isoleucine and valine promoted leanness and improved the regulation of blood sugar.

Over an eight - week period, a control group of mice fed a high - fat diet predictably became obese, but the mice whose Hedgehog pathway had been activated didn't gain any more weight than another control group fed on a normal diet.

The activation of a protein pathway in fat cells in the mice allowed the animals to be fed a high - fat diet without becoming obese.

Lean and diet - induced obese mice were used to characterize single - dose in vivo pharmacological effects of IRAB - A; multiple - dose IRAB - A effects were tested in obese mice.

Obese mice that ate a high - fat diet along with the green tea compound EGCG (Epigallocatechin -3-gallate) gained weight significantly more slowly compared to a control group of mice which didn't get the green tea supplement.

In a study of obese mice that received a diet rich in either coconut or safflower oil, mice that received the coconut oil were found to have made much less fat cells than mice that received the safflower oil.

This idea is supported by animal studies, showing that mice without any bacteria in their intestines had lower amounts of body fat, and did not become obese or insulin resistant when put on a high - fat diet.

Male C57BL / 6J obese mice fed a high - fat diet for 12 weeks and genetically diabetic db / db mice at an age of 6 weeks received dietary C3G supplementation (0.2 %) for 5 weeks.

Green tea -LRB--)- epigallocatechin -3-gallate reduces body weight with regulation of multiple genes expression in adipose tissue of diet - induced obese mice

One - half of the mice on the HF diet developed obesity (diet - induced obese (DIO) mice), whereas the remaining mice were diet resistant (DR).

In a later step of this study, microbiota from obese mice fed with a western diet were transferred to the microbiota - free mice.

In rodents, ketogenic diets reduce reactive oxygen species in the brain34 and reduce central inflammation and reactive oxygen species in a model of multiple sclerosis.35 Two clinical papers have found that ketogenic diet feeding of 12 weeks to 6 months reduced signs of liver inflammation in obese patients with nonalcoholic fatty liver disease (in addition to improving various other physiological and biochemical variables).36, 37 Unfortunately, basic research into non-alcoholic fatty liver disease has been hampered by species differences between mice and humans in their hepatic reaction to ketogenic diets.38

in 2016, genetically identical mice that consumed a high - fat diet were more likely to produce obese offspring with impaired glucose tolerance, an early sign of type 2 diabetes.

When mice are obese and they are allowed to eat as much of they want of a high fat diet, they gained twice as much weight as the non obese mice eating the same high fat diet.

All we have to go on is preclinical data in mice (and many of these mice are obese and raised in crowded cages6), and we must remember this, especially with patients and their families who are at wit's end because they are unable to effectively follow the diet.