Sentences with phrase «diets in normal mice»

Intrigued, Turek joined with endocrinologist Joseph Bass, also at Northwestern, to study the effects of regular and high - fat diets in normal mice and mice with a dysfunctional Clock gene.

Not exact matches

Three groups of middle - aged mice (about a year old) were studied: one group ate a normal diet, in which fewer than 30 percent of calories came from fat, while two others were fed high - calorie diets in which 60 percent of the calories came from fat.

Laboratory mice that have received rapamycin have reduced the age - dependent decline in spontaneous activity, demonstrated more fitness, improved cognition and cardiovascular health, had less cancer and lived substantially longer than mice fed a normal diet.

Lastly, they plan to vary the timing of exposure to the various diets in the mouse model of autism, by, for example, giving pregnant mice a high - glycemic index diet and then keeping their pups on a normal diet.

In a separate study, Steven Kliewer, a molecular biologist at the University of Texas Southwestern Medical Center in Dallas, and colleagues fed normal mice and transgenic mice that overproduce the hormone a regular diet, then starved them for a daIn a separate study, Steven Kliewer, a molecular biologist at the University of Texas Southwestern Medical Center in Dallas, and colleagues fed normal mice and transgenic mice that overproduce the hormone a regular diet, then starved them for a dain Dallas, and colleagues fed normal mice and transgenic mice that overproduce the hormone a regular diet, then starved them for a day.

When fed a diet containing cholesterol, saturated fat, and bile acids for 3 weeks, the transgenic mice, in contrast to normal mice, did not develop a detectable increase in plasma LDL.

In this research, after just four weeks on a high - fat or a high - sugar diet, the performance of mice on various tests of mental and physical function began to drop, compared to animals on a normal diet.

If they have the choice, normal behavior in mice is to prefer a high - fat diet to simpler foods.

That research showed that mice on a normal diet who were exposed to low doses of antibiotics throughout life, similar to what occurs in commercial livestock, packed on 10 to 15 percent more fat than untreated mice and had a markedly altered metabolism in their liver.

Monitoring groups of mice, one group receiving normal levels of protein in the diet and the other group nourished with low levels of protein for five weeks, researchers were able to uncover the damaging effect a reduction of protein can cause to the structure of this vital organ.

However, Brian Delaney, who is president of the Calorie Restriction Society, an organisation that supports the practice in people, says some who follow this diet are disappointed by the relatively modest benefits in monkeys compared with mice, which have lived up to 50 per cent longer than normal.

The mice that were fed a calorie - restricted diet, mainly by a reduction in their carbohydrate intake, over a period of six months, had fewer disease symptoms than their normal - diet counterparts.

Compared to the mice that had normal amounts of vitamin E in their diet, the mice fed extra vitamin E had:

Compared with normal chow diet - fed mice, the high - fat diet mice showed worsened blood sugar, increased triglycerides, a type of fat (lipid) in the blood, and a substantial increase in the numbers of CD8 + T cells in the liver.

The researchers found that in genetically - modified mice lacking Interferon - 1, who were also fed a high - fat diet, the CD8 + T cells did not produce an inflammatory response, and the mice had near normal blood sugar levels.

The older mice fed a diet containing extra amounts of vitamin E, the equivalent to about 200 IU / day consumed by humans — about 10 times the Recommended Daily Allowance but well below the upper limit — were far more resistant to the bacteria than the older mice that had a normal amount of vitamin E in their diet.

Interestingly NPGL levels, which plummeted in the 5 - week - long high - fat - diet mice — fell back to normal levels in mice who gorged themselves for the longer period of 13 weeks.

Dr. Verdin further found that prolonged intake of a high - fat diet, even in normal mice, can itself reduce the activity of the enzyme produced by SIRT3 — an enzyme his laboratory originally discovered.

Some studies have identified a number of regions of methylated DNA (one key way in which epigenetic changes occur) that are different in fat cells of mice fed high - fat diets than in cells of mice with normal diets.

Because the placenta also plays an important role in nutrient allocation (as previous studies have shown), the babies of mice fed the obesogenic diet were still born at a normal size.

Body composition was unaltered in Lyplal1 knockout mice as assessed by Dual - energy X-ray absorptiometry (DEXA) scanning, both on normal chow and on a high fat diet.

The rats who ate non palatable chow and were on normal «diets» were perfectly fine; the rats who had eaten sweets but were on a normal diet ate about 20 % more; the rats who had been in restricted cycling patterns and refed on sweets ate 80 % more than control mice on normal diets.

«Low - Calorie Diet Slows Aging in Mice in Study,» claimed a recent headline.17 According to the article, «Putting elderly mice on a very low - calorie diet for as little as four weeks reversed many of the changes in the activity of various genes that had occurred during normal aging...» The resesearchers were not looking at actual signs of disease, nor were they measuring lifespan, but instead focused on the analysis of 11,000 different genes using a method called microarray technology in which Spindler has large financial holdiMice in Study,» claimed a recent headline.17 According to the article, «Putting elderly mice on a very low - calorie diet for as little as four weeks reversed many of the changes in the activity of various genes that had occurred during normal aging...» The resesearchers were not looking at actual signs of disease, nor were they measuring lifespan, but instead focused on the analysis of 11,000 different genes using a method called microarray technology in which Spindler has large financial holdimice on a very low - calorie diet for as little as four weeks reversed many of the changes in the activity of various genes that had occurred during normal aging...» The resesearchers were not looking at actual signs of disease, nor were they measuring lifespan, but instead focused on the analysis of 11,000 different genes using a method called microarray technology in which Spindler has large financial holdings.

Tumor - bearing mice fed diets high in MCTs were found to have reduced levels of the enzyme fatty acid synthase and also reduced acetyl CoA, similar to tumor free mice, suggesting cancer cell metabolism was restored back to that of normal cells.94

However, when methionine - rich diets are used to induce hyperhomocysteinemia... Mice fed methionine - rich diets had significant atheromatous pathology in the aortic arch even with normal plasma homocysteine levels, whereas mice fed B vitamin - deficient diets developed severe hyperhomocysteinemia without any increase in vascular patholMice fed methionine - rich diets had significant atheromatous pathology in the aortic arch even with normal plasma homocysteine levels, whereas mice fed B vitamin - deficient diets developed severe hyperhomocysteinemia without any increase in vascular patholmice fed B vitamin - deficient diets developed severe hyperhomocysteinemia without any increase in vascular pathology.

Moreover, it should be noted that ketogenic diets are only relatively high in protein18, 106 and that some recent studies have demonstrated that VLCKD can even cause a regression of diabetic nephropathy in mice.109 With regard to possible acidosis during VLCKD, as the concentration of KBs never rises above 8 mmol / l10 this risk is virtually inexistent in subjects with normal insulin function.