Sentences with phrase «difference in gene expression»

They found significant differences in gene expression patterns and DNA modifications between donors under the age of 9 and those older than 28.

The group looked for differences in gene expression by comparing levels of messenger RNA — the middle - man between gene and protein production — throughout the entire genome.

However, there were no significant differences in gene expression between baseline and three months in the non-responders.

To see what genes might be involved in this increased aggression, the team used microarrays to look for differences in gene expression in fly brains.

«There was also a big difference in gene expression of a specific enzyme called nicotinamide N - methyltransferase.»

When the researchers started taking weeds out of the corn at early points, such as when the corn had as few as two and four leaves, they still saw differences in gene expression when compared to corn without weeds.

Dr. Hardison noted that the opposite is also true: researchers need to take into account systematic differences in gene expression patterns between the species when considering the mouse as a model for humans.

Their results showed that both forms of RP had clear differences in gene expression compared to normal retinas.

«We are currently in the process of identifying differences in gene expression and neuroanatomy in these birds to better understand the neural mechanisms of these cognitive deficits,» says Roth.

In this case, the study authors say, differences in gene expression over the course of a day may cause a person's heart to heal more quickly in the afternoon than in the morning.

David Relman, whose lab at Stanford University studies host reaction to infections as well, has some qualms about the team's methodology; for instance, he wonders if their results could be due to the fact that different cell types are present in the lungs during a severe infection, rather than to true differences in gene expression.

«In our opinion, most of the published protocols to generate so - called naïve stem cells are not convincing because they produce cells that are very much like the starting cells — there's not much difference in gene expression,» says co-senior author Rudolf Jaenisch of the Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology.

He has been studying differences in gene expression in infected and uninfected plants and finds that the fungus seems to increase the activity of genes involved in seed production.

The team found deep conservation of certain processes that likely reflects similar underlying regulatory processes between mouse and man, but there were also significant differences in gene expression during kidney development, as well as in the timing, scale, organization, and molecular profile of key cell types and cell structures.

«There are incredible differences in gene expression, especially in the pituitary,» Calisi said.

A baseline study shows major differences in gene expression in the hypothalamus and pituitary between male and female pigeons.

This, together with other findings, suggests, that in the slave - raiding ants differences in gene expressions, i.e., the reading of the gene sequence and the transcription into proteins, is solely geared toward the raid.

The findings, published recently in Nature, uphold the mouse model of human disease, but pinpoint important differences in gene expression that will guide future health research.

«Population differences in gene expression have only recently begun to be investigated,» said Dolan, «We believe they play a significant role in susceptibility to disease and in regulating drug response.

The ability of these populations to interconvert in vitro combined with their subtle differences in gene expression lead us to ask if there was any functional significance to this low level of PrEn gene expression.

We compared the transcriptomes from VNO and OM of both male and female mice to assess whether differences in gene expression in these tissues could underpin sexually dimorphic behaviors [17].

«Based on our data, which is comprised of gene expression across 16 brain regions, we found that the most distinct region, i.e. the region where we observe more human - specific differences in gene expression, is the striatum, a region involved in motor coordination, reward, and decision - making,» lead author André M. Sousa of the Yale School of Medicine and the Kavli Institute for Neuroscience told Seeker.

To test the notion that this low level of transcription at the Hex locus producing the V+S + fraction in ES cell culture represented an immediate early state in PrEn differentiation, we examined global differences in gene expression.

Differences in gene expression levels between people of European versus African ancestry can affect how each group responds to certain drugs or fights off specific infections, report researchers from the University of Chicago Medical Center and the Expression Research Laboratory at Affymetrix Inc. of Santa Clara, CA.

In these images of rat brains, differences in gene expression of genes for fibroblast growth factor 2 (FGF2, top set) and dopamine 2 receptor (D2, bottom sett) can be seen in rats of two breeds before (left) and after (right) cocaine exposure.

They compared space - flown endothelial cells to endothelial cells cultured under normal gravity, looking for differences in gene expression and / or in the profile of secreted proteins.

For example, the nuclei in the centers of the mutant organoids moved more slowly, and we saw significant differences in gene expression.»

The authors are now working to understand how selection acts differently on males and females, and how this leads to differences in gene expression between the sexes.

In the healthy weight subjects, the difference in gene expressions were not significant.

Other scientists on the eLife review board were also impressed with the results of Dr. Espinosa's research publicly stating: «These findings have important implications for understanding the basic nature of, and individual variation in, the diverse phenotypes of people with Down syndrome,» and «This is clearly an interesting and significant study that provides important new insights into the differences in gene expression in trisomy 21 cells.»

Pääbo has also found that differences in gene expression (how active a gene is) may have played a role in creating the gap between chimp and human brains.

Differences in gene expression may thus explain how largely similar genomes create such different organisms.

Differences in gene expression may have given us bigger brains, but in this movie scene, the chimp comes out on top.

Differences in gene expression are likely to specify much of the phenotypic differences between and within species.

Comparison of the differences in gene expression between the V+S + and V − S + fractions supports this idea.

The only clue indicating that differences in gene expression level are not the reason for the observed correlation between the recombination rate and the size of introns is that we do not see a comparable pattern when examining the size of exons, the number of exons per gene, and the overall size of proteins.

However, differences in gene expression levels can not explain the observed negative correlation between the recombination rate and the distance between genes.

The difference in gene expressions were not significant in the normal weight individuals.