Sentences with phrase «different angiogenesis inhibitors»
Because of Dr. Folkman's vision, at least 23 different angiogenesis inhibitors have been approved by the FDA for 18 different indications, with 100 different drugs being tested in over 3,000 clinical trials in approximately 43 countries.
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Nintedanib, in addition to blocking vascular endothelial growth factor receptors (VEGFR) and platelet derived growth factor receptors (PDGFR), also acts on fibroblast growth factor receptors (FGFR), which makes it different to classical angiogenesis inhibitors.
In the mouse model, treating node metastases with two angiogenesis inhibitors that have different mechanisms of action did not change the density of blood vessels or the growth of the metastases.