Sentences with phrase «different antibody binding»
a) To measure the overlap coefficient of different antibody binding sites, the signals were separated from background using a brightness criterion and made binary.
https://actaneurocomms.biomedcentral.com/ Not exact matches
In such patients, a phenomenon called «antibody - dependent enhancement» (ADE) takes place, during which antibodies that were generated during the first infection bind but do not destroy the slightly different newly infecting virus, but instead facilitate its infection of immune cells.
Some of the mice were inoculated with antibodies binding to different DENV serotypes, whereas a second group was naïve, that is, they did not have any anti-DENV antibodies.
«But when we looked at the different stages of breathing that have already been recognised, we found that this antibody - binding site was still hidden.
Second, the safety of designer proteins will have to be studied carefully, Crowe says, because they are markedly different than natural HA - binding antibodies.
Teijaro adds that the ideal approach may be to combine the HIS virus vaccine with a strategy to generate broadly neutralizing antibodies — those that can bind many different influenza strains — to create a universal flu vaccine (SN: 10/28/17, p. 18).
However, high levels of a different type of envelope - binding antibody belonging to the IgA family were associated with a lack of protection against HIV infection.
When low levels of antibodies from a previous dengue infection sense a new serotype is around, they weakly bind to the different serotype, lead it to cells with receptors for their constant regions, and the new serotype ultimately enters those cells.
These neutralizing llama antibodies target different areas of the CD4 - binding site of the virus, therefore breadth and potency are increased when they are used in combination.
This antibody binds to the D664KW666 core 2F5 epitope but use entirely different germ line V genes from 2F5 and that are significantly less divergent than 2F5 from thei
The overall score encompass several factors: reproducibility of the antibody staining in different cell lines (and if signal strength correlates with RNA expression levels); assays for enhanced antibody validation by using antibodies binding to different epitopes on the same target protein (independent antibodies), by knockdown / knockout of the target protein (genetic methods) and by matching of the signal with a GFP - tagged protein (recombinant expression); experimental evidence for location described in literature.
Antibodies included in the Human Protein Atlas have been analyzed without further efforts to optimize the procedure and therefore it can not be excluded that certain observed binding properties are due to technical rather than biological reasons and that further optimization could result in a different outcome.
and affinity of antibody ACI - 5400 were characterized by a panel of methods: (i) measuring the selectivity for a specific phospho - Tau epitope known to be associated with tauopathy, (ii) performing a combination of peptide and protein binding assays, (iii) staining of brain sections from mouse preclinical tauopathy models and from human subjects representing six different tauopathies, and (iv) evaluating the selective binding to pathological epitopes on extracts from tauopathy brains in non-denaturing sandwich assays.