Novartis is typically looking at an extremely high number of
different antibody sequences to identify the single one having the desired properties.
Not exact matches
In a study published in the May 29, 2014, edition of Molecular Ecology Resources, Duke researchers Peter Larsen, Ryan Campbell and Anne Yoder used high - throughput
sequencing on sifaka blood samples to generate
sequence data for more than 150,000
different sifaka
antibodies — protective molecules that latch on to bacteria, viruses and other foreign invaders in the body and fight them off before they cause infection.
Data from in vivo mouse models indicate that delivery of the DMAb
sequence for the influenza A-targeted monoclonal
antibody protected against lethal doses of two very
different, clinically relevant influenza A viruses.
An article published on June 26th in PLOS Pathogens now reports that a mini
antibody called 3D8 scFv can degrade (or chew up) viral DNA and RNA regardless of specific
sequences and protect mammalian cells and genetically manipulated mice against
different viruses.
Collection of blood samples for Anti PfSPZ
antibodies and RNA
sequencing at
different time points.