Ransohoff reminds the audience that dysfunctional microglia can cause several
different brain diseases.
Richard Ransohoff (Biogen) studies a process called «inflammation» in the brain in
different brain diseases.
«Now, our goal is to see how this mechanism is affected in
different brain diseases and determine if it can be harnessed to protect neurons and ultimately preserve brain function.»
Not exact matches
After many setbacks, researchers have been trying
different approaches to treating the neurodegenerative
disease, such as starting treatment earlier and finding new ways to target the
brain.
If the Sun or the Moon were a tiny bit
different, perhaps we wouldn't be here; but perhaps we would be - and possibly we would be even better, with sturdier bodies, larger, more active
brains, better resistance to
disease, etc..
The symptoms are caused by
different diseases, which affect the
brain, such as Alzheimer's.
If conditions on Earth were
different, we would be
different — perhaps even better, though, with stronger bodies, fewer tendencies to
disease and larger
brains to figure out answers more easily and completely.
Since the first human
brain organoids were created from stem cells in 2013, scientists have gotten them to form structures like those in the
brains of fetuses, to sprout dozens of
different kinds of
brain cells, and to develop abnormalities like those causing neurological
diseases such as Timothy syndrome.
By subdividing the
brain more strategically, the map can help pinpoint particular sections» functions and help determine how
different cortical regions contribute to development, aging and
disease.
«The method supports detecting microRNAs directly from very small volumes of CSF to potentially get an indication of
different types of
diseases, including amyotrophic lateral sclerosis (ALS), Alzheimers, Huntingdon's, and traumatic
brain injuries,» says Pregibon.
The behavioral tests used here modeled one dimension of the
disease — an inability to experience pleasure from normal activities — but not others, such as stress and anxiety, and probably tap into
different brain mechanisms in mice than in humans, he says.
As for the Lund researchers, the method provides a tool for studying how neurons cooperate inside a healthy
brain and in animal models with
different neurological
diseases.
Raising further doubt, a team led by Douglas Galasko, director of the Alzheimer's
Disease Research Center at the University of California, San Diego, twice tried to find BMAA in Chamorros and North Americans who died of brain disease — and both times came up empty - handed, though using a different method of chemical identification than the one employed by Cox and the Miam
Disease Research Center at the University of California, San Diego, twice tried to find BMAA in Chamorros and North Americans who died of
brain disease — and both times came up empty - handed, though using a different method of chemical identification than the one employed by Cox and the Miam
disease — and both times came up empty - handed, though using a
different method of chemical identification than the one employed by Cox and the Miami team.
Neurodegenerative
diseases are caused by the death of neurons and other cells in the
brain, with
different diseases affecting
different regions of the
brain.
Two kinds of mouse glial
brain cells, microglia and astrocytes, making
different versions of the APOE protein were grown with
brain nerve cells, or neurons, that make
disease - causing forms of tau.
To demonstrate the chip's efficacy in modeling
disease, the team doped
different regions of the
brain with the drug Phencyclidine hydrochloride — commonly known as PCP — which simulates schizophrenia.
«This shows how important it is to implement
different brain regions into in vitro models, especially when studying how neurological
diseases impact connected regions of the
brain.»
Brains of patients with Alzheimer's
disease clog up too, but with plaques made from a
different protein called amyloid beta peptide.
By comparing doctor's reports of a patient's symptoms with images of the patient's
brain post-mortem, they may be able to classify
different categories of Alzheimer's
disease.
A molecule that helps cells stick together is significantly over-produced in two very
different diseases — rheumatoid arthritis and a variety of cancers, including breast and
brain tumors, concludes a new study.
The
brain of a female migraineur looks so unlike the
brain of a male migraineur, asserts Harvard scientist Nasim Maleki, that we should think of migraines in men and women as «
different diseases altogether.»
They focused on three
different types of PVD: arterial
disease in the lower extremities, called peripheral artery
disease; carotid artery stenosis, which is blockage in the carotid arteries, the major blood vessels in the neck that supply blood to the
brain, neck and face; and abdominal aortic aneurysm, an enlargement of the lower aorta, the major blood vessel that supplies blood to the body.
A report published in The Lancet Neurology evaluates for the first time how well
different types of
brain imaging tests work to detect Alzheimer's and predict how the
disease will progress.
BRAIN MAZE Even before symptoms show up, young people who have a version of a gene linked to Alzheimer's disease tap into different areas of the brain to navigate through a virtual reality
BRAIN MAZE Even before symptoms show up, young people who have a version of a gene linked to Alzheimer's
disease tap into
different areas of the
brain to navigate through a virtual reality
brain to navigate through a virtual reality maze.
«New possibility of studying how Alzheimer's
disease affects the
brain at
different ages.»
That variety cropped up in a
different part of the
brain than the other strains, and it also produced clumps of proteins akin to the amyloid plaques found in sporadic Creutzfeldt - Jakob
disease, a fatal
brain disease of unknown origin that usually affects those over age 55.
Brain cells from
different people vary in their susceptibility to Zika infections, says infectious
disease researcher Scott Weaver, also at the University of Texas Medical Branch but not involved in the study.
Damage to the olfactory receptor neurons because of a respiratory infection, a head injury or a neurodegenerative
disease can disrupt the
brain's ability to process
different smells.
This could, for example, be a normal
brain and a
diseased brain, or the same
brain at two
different stages of development.
Our investigations also open a new route for understanding how
different physiological states of the body influence stem cells in the
brain during health and
disease, and opens new ways for thinking about therapy,» says Fiona Doetsch.
This is very
different from the idea dominant in psychiatry, that mental illness is a
brain disease.
Each form of Alzheimer's
disease should perturb
different brain networks and so influence the concentration of
different proteins that can be measured in the blood.
«Although
different types of
brain stimulation are currently applied in different locations, we found that the targets used to treat the same disease are nodes in the same connected brain network,» says first author Michael D. Fox, MD, PhD, an investigator in the Berenson - Allen Center for Noninvasive Brain Stimulation and in the Parkinson's Disease and Movement Disorders Center at B
brain stimulation are currently applied in
different locations, we found that the targets used to treat the same
disease are nodes in the same connected brain network,» says first author Michael D. Fox, MD, PhD, an investigator in the Berenson - Allen Center for Noninvasive Brain Stimulation and in the Parkinson's Disease and Movement Disorders Center at
disease are nodes in the same connected
brain network,» says first author Michael D. Fox, MD, PhD, an investigator in the Berenson - Allen Center for Noninvasive Brain Stimulation and in the Parkinson's Disease and Movement Disorders Center at B
brain network,» says first author Michael D. Fox, MD, PhD, an investigator in the Berenson - Allen Center for Noninvasive
Brain Stimulation and in the Parkinson's Disease and Movement Disorders Center at B
Brain Stimulation and in the Parkinson's
Disease and Movement Disorders Center at
Disease and Movement Disorders Center at BIDMC.
It binds to the beta - amyloid plaques that characterize Alzheimer's
disease, helping to measure the extent to which plaques have formed in
different brain regions.
For the last decade, neuroscientists have been using the non-invasive
brain - mapping technique functional called magnetic resonance imaging or fMRI to examine activity patterns in human and animal
brains in the resting state in order to figure out how
different parts of the
brain are connected and to identify the changes that occur in neurological and psychiatric
diseases.
«As we're trying
different types of
brain stimulation for
different diseases, the question comes up, «How does one relate to the other?
The mutations take place on a protein that serves as the precursor for amyloid beta, a
different protein that forms plaques in the
brains of individuals afflicted by Alzheimer's
disease.
New York, NY (February 1, 2012)-- For decades, researchers have debated whether Alzheimer's
disease starts independently in vulnerable
brain regions at
different times, or if it begins in one region and then spreads to neuroanatomically connected areas.
One is about understanding how the function of the
brain circuitry is altered by
different movement - related
disease processes, such as stroke and Parkinson's
disease.
It isn't too
different from how electroshock therapy works to counter certain mental illnesses and how deep -
brain stimulation smooths motion disorders such as multiple sclerosis and Parkinson's
disease.
This unique pattern of
brain cell death causes
different symptoms in each
disease.
By directly altering the gene coding for the prion protein (PrP), Whitehead Institute researchers have created mouse models of two neurodegenerative prion
diseases, each of which manifests in
different regions of the
brain.
The mass die - off of nerve cells in the
brains of people with Alzheimer's
disease may largely occur because an entirely
different class of
brain cells, called microglia, begin to fall down on the job, according to a new study by researchers at the Stanford University School of Medicine.
The Group studies how transporter proteins (in normal and
diseased brains of
different ages) modulate the extracellular spatiotemporal concentration profiles of excitatory (glutamate and aspartate) and inhibitory (GABA and glycine) transmitter amino acids.
In addition to explaining how
different diseases affect the
brain, Jin's research might point the way for new therapies for these disorders.
In collaboration with the University of California, Davis, D'Azzo and her colleagues have begun checking NEU1 levels in
brain tissue of Alzheimer's patients at
different stages of the
disease.
In this work, we transplanted hematopoietic stem and progenitor cells into the substantia nigra of
brains of two
different mouse models of Parkinson's
disease.
«We've learned a lot about the
brain from mice, but I think we can all agree that mice and humans are very
different,» says Li - Huei Tsai, a neuroscientist at the Picower Institute for Memory and Learning at MIT who studies the neurobiology of Alzheimer's
disease.
Extensive damage to white matter (myelin - rich
brain areas) characterizes Alzheimer's
disease, Huntington's
disease, and Parkinson's
disease, pointing to myelin damage and oligodendrocyte impairment as a common path to the progression of these
diseases, even though each of these
diseases may have a
different cause.
The benefits of using olfactory receptor neuron samples to study psychiatric disorders and patient responsiveness include their similarity to
brain neurons, the relatively easy biopsy procedure, and the potential for scientists to sample and compare cells from the same patients throughout several
different stages of
disease.