Not exact matches
Human
breast cancers can be classified according to their histological and molecular features into
different subtypes, including luminal, ERBB2 and basal - like
tumors.
The study published in Cancer Cell shows that exosomes from
tumor cells of
breast cancer (and other
tumor types such as ovarian and endometrial) are
different in size and composition than those of healthy cells.
Comparing the metastasized
tumors with the original
breast tumors, the researchers were surprised to learn that multiple, slightly genetically
different cells from the original site had broken away together and established the new
tumors.
Navin's team developed a new sequencing approach called Nuc - Seq, revealing that
different subtypes of
breast cancer displayed varied
tumor diversity.
The researchers then compared
tumor cells isolated from multiple
different breast cancer patients and found that cells expressing lower amounts of Numb - 1 and -2 were more resistant to the chemotherapy agent cisplatin.
A molecule that helps cells stick together is significantly over-produced in two very
different diseases — rheumatoid arthritis and a variety of cancers, including
breast and brain
tumors, concludes a new study.
The resulting «map» of gene - drug interactions allowed the researchers to accurately predict the responses of multiple human cancer cell lines to
different chemotherapy agents based on the cell lines» genetic profiles and also revealed new genetic factors that appear to determine the response of
breast and ovarian
tumor cells to common classes of chemotherapy treatment.
Using all the existing data that was available, Andrechek, along with MSU doctoral student Daniel Hollern, analyzed 1,172 mouse mammary
tumor samples from 26
different preclinical models and was able to compile one of the largest databases to show which strains of mice were best suited to study a particular type of human
breast cancer.
Different tumor subtypes can include glandular, which include the mammary glands, as well as squamous, which are very rare and involve epithelial cells that line the inside of the
breast.
They showed that the iKnife could distinguish normal and
tumor tissues from
different organs, such as
breast, liver, and brain, and could even identify the origin of a
tumor that was a metastasis, a secondary growth seeded by a primary
tumor elsewhere in the body.
Different types of
tumors show a preference for specific organs and tissues; circulating
breast cancer cells, for example, are likely to take root in bones, lungs, and the brain.
The team also found that these genes had
different functions in promoting metastasis: One group encouraged growth of
tumor cells in both
breast and lungs, whereas the other only helped the new
tumor thrive in the lungs.
«This was unexpected and suggests fundamental but unrecognized differences in drug action in
tumor cells from
different individuals having the same disease — in this case,
breast cancer.»
The study evaluated the efficacy and safety of cabozantinib compared to placebo in 9
different solid
tumor types including
breast, lung, ovarian, and prostate.
In the awarded research, Allison Cleary used the mouse model MMTV - Wnt1, which spontaneously develop
breast tumors, to explore the relationship between the
different cell clones.
-- discovery awarded international science prize Researcher Allison Cleary has, for the first time, demonstrated that
different types of
tumor cells cooperate in the development and growth of
breast cancer.
Researcher Allison Cleary has, for the first time, demonstrated that
different types of
tumor cells cooperate in the development and growth of
breast cancer.
Breast cancer research and treatment have long focused on a patient's original
tumor as a guide to preventing relapse; however, research suggests that some recurrent cancers are
different from the primary
tumor and may respond better to
different therapies.
I had a hunch based on this work that microRNA expression would be
different in
breast cancer stem cells than in more differentiated
tumor cells or normal tissue and that it would change as the stem cells differentiated to form a
tumor.
The challenge is that these mutations are «personal» to the
tumor and patient; i.e., not all types of
breast cancer carry the same set of mutations, and as a result,
different patients have a
different, personal set of mutations.
This
tumor recurrence often shows up in
different sites such bones, lung, liver, or brain and primarily responsible for
breast cancer related deaths.
(Source) Another study found lyophilized strawberries to inhibit oral tumorogenesis in hamsters (source), while a
different study investigated the effects of strawberry extract on leukemia and
breast cancer cells, and discovered the extract to inhibit
tumor proliferation by causing cell death.
The doctor reading your mammogram will be looking for
different types of
breast changes, such as small white spots called calcifications, lumps or
tumors called masses, and other suspicious areas that could be signs of cancer.