Sentences with phrase «different cell therapy»

There has been a significant trend in biotechnology with companies investing in different cell therapy workflows.

The experimental and clinical studies show that different cell therapy methods lead to different results of efficiency.

Not exact matches

That means that the stem - cell therapies have to be converted into whatever cell they're meant to be (heart - muscle cells, neurons, and so forth) before going into the body, rather than using different kinds of stem cells to treat the condition.

They isolated blood cells from HIV - positive patients on antiretroviral therapy and at different stages of disease progression, as well as cells from non-infected individuals.

The Wyss team believes the ability of the human gut - on - a-chip to culture the microbiome with human gut cells also holds promise for the field of precision medicine, where a patient's own cells and gut microbiota could one day be cultured inside a gut - on - a-chip for testing different therapies and identifying an individualized treatment strategy.

But in many cell lines and patient samples that developed resistance to the combination therapy, the researchers observed something different happening.

Researchers are developing many different versions of CAR - T cell therapies, but the basic premise is the same: Doctors remove a patient's T cells (immune system cells that attack invaders) from a blood sample and genetically modify them to produce artificial proteins on their surfaces.

«This could be useful in developing new combination therapies, where multiple drugs are used simultaneously to treat a cancer by attacking different parts of the cancer cells at the same time.»

«This could lead to personalized therapy where we can look at how an individual's cells respond to different therapeutic cocktails,» said Mirkin, whose lab developed NanoFlares in 2007.

«Now you can think about collecting a patient's cells and studying how those cells respond to different therapies.

They will also investigate different combination therapies, looking at those used for other conditions that may be effective in reducing HIV - infected cells.

For a typical cell therapy, heart cells are made from different stem cells, but the quality of the heart cells will vary.

The team designed a different approach to study the therapy in myeloma, adding in an infusion of the patient's own stem cells along with their lymphodepleting chemotherapy (melphalan), followed by CTL019 infusion about two weeks later.

If these preclinical studies are successful, the researchers plan to further develop their CAR T cell therapy and test its safety and efficacy for different types of metastatic cancer in upcoming clinical trials.

Our investigations also open a new route for understanding how different physiological states of the body influence stem cells in the brain during health and disease, and opens new ways for thinking about therapy,» says Fiona Doetsch.

Today, at 56, Atala oversees 300 researchers and support personnel, including chemists, biologists and engineers divided into different teams working on cell therapy, a technology for what he calls partial transplants and the creation of new organs.

The group is now investigating the different pathways in which iNKT cells can be formed and identifying which are best for cancer therapy.

Takahashi predicts that in the future, selecting from different stem cell therapies will «depend on the target disease and the situation of the host.»

Researchers at the Institute for Stem Cell Therapy and Exploration of Monogenic Diseases (I - Stem — Inserm / AFM / UEVE), in collaboration with CNRS and Paris Descartes University, have recently developed a new approach to better control the differentiation of human pluripotent stem cells, and thus produce different populations of motor neurons from these cells in only 14 days.

It is the first time that a gene therapy based on genetically modified stem cells is tested in a multicenter, international clinical trial that shows a reproducible and robust therapeutic effect in different centers and different countries.

Researchers at the Institute for Stem Cell Therapy and Exploration of Monogenic Diseases (I - Stem — Inserm / AFM / UEVE) have recently developed a new approach to produce different populations of motor neurons from these cells in only 14 days.

Can you tell us how it's different from other types of T cell therapies?

«Thanks to work by Lorenz and others, we can now generate 50 different cell types, which could be used to develop new therapies or create powerful disease models.

After hearing a brief explanation that laid out the different sources of stem cells (but left undiscussed their current uses or future potential for therapy), the respondents offered a slightly more nuanced set of views, and only a slight majority (52 %) supported embryonic stem cell research.

The researchers used the new technique to mutate the genes CXCR4 and CCR5, which encode receptor molecules that different strains of the HIV virus use to sneak in and infect immune cells and which have been targeted in previous cell therapy trials.

Due to the high efficiency of establishing organoid models from different tissues and diseases, such as cancer, organoid technology allows the generation of large living biobanks of tumor organoids that are amenable for middle - throughput drug screens and may allow personalized therapy design, as a complement to cell line and xenograft - based drug studies (7,19).

Dr. Allison: The way the field of immunotherapy is going now is toward combinatorial therapies, where we combine these different immune checkpoints blockers, and also combine these with drugs that actually kill tumor cells.

The finding, published in the current issue of Genes and Development1 represents a different approach to cultivating specialized cells for transplant therapy than that being pursued in other labs.

A concentrated source of information on cell therapies spanning the different stages of development: including research, pre-clinical, clinical and marketed phases, being pursued by both non-profit organizations (NPO) and industries.

But if, as this study suggests, the way that cells become proliferative again is similar across many different organs, we can imagine therapies that interfere with cancer initiation in a more global way, regardless of where that cancer may appear in the body,» he explains.

The central points of immunology are identifying and distinguishing the many different immune cells that are essential for diagnosis and therapy.

That has been in part a result of how much response efficacy that has been achieved with some patients in addition to work with different types of gene therapy applications and coupling those with cell therapy advancements.

[38] Although the results of the trials of cell therapy for PD were mixed, with only a minority of patients showing clear - cut and durable gains, researchers have subsequently gained substantial insight into the reasons underlying differential outcomes at different centers and amongst different protocols, and for the troubling dyskinesias that were suffered by some patients.

Tumor heterogeneity, i.e., the differences between cells within one tumor, among different tumor lesions of the same patient, or between patients even if the tumors are of similar genetic signatures, provides major challenges for future therapy.

The WFIRM research team is working to engineer replacement tissues and organs and develop healing cell therapies for more than 30 different areas of the body.

We learn which specific genes are expressed in cancer cells and how a patient may respond to different therapies, so that we can select the most appropriate targeted treatment for the particular cancer.

Using different mouse models of cancer, a therapy consisting of antibodies which block the PD - 1 / PD - L1 checkpoint to boost the ability of T cells to fight cancer cells was used in combination with anti-CD27 antibodies, which activate T cells via the receptor CD27.

Autologous cell therapies require a fundamentally different manufacturing approach, and we did not identify any DSTs designed specifically for such processes.

In Sabrina's poster, she showed that patients with a low number of different types of T - cells (a type of immune cell which has different versions to fight different infections / diseases; called a T - cell repertoire or TCR) in their blood at start of treatment were more likey to respond to anti-PD1 therapy, and had a poor response to anti-CTLA4 therapy.

Repopulation of the immune system is carried out via cell transplants that are by now a safe and proven application of stem cell medicine, little different from the many varieties of first generation stem cell therapy.

And the ability to efficiently and precisely modify the DNA in these cells offers enormous potential for the development of personalized stem cell therapies that benefit people with many different types of genetic disorders.

This form of therapy has been used in different ways since the 1700s to decrease pain and muscle spasms, improve recovery, slow cell aging and improve health.

Williams and his colleagues are studying a different approach to sickle cell gene therapy.

There are several different treatments being compared, including: surgery followed by vaccine - based immunotherapy, surgery followed by oncolytic virus therapy, surgery followed by IL - 12 gene therapy and biopsy followed by placement of a specialized catheter system that draws tumor cells out of the brain.

She also points out that there is a lack of scientific support for different therapies that are requested by owners and a need for more careful assessment of the value of stem cells taken from the patient.

Simply put, these therapies are based on the overall concept that utilizing different forms of vibrating energy can actually heal a pet's diseased or injured cells.