Sentences with phrase «different cell types»

The research highlights the importance of investigating different cell types in normal human tissues to understand the cellular origin of cancer and the factors that may contribute to its development.

Such an alternative pathway could open the door to the preparation of different cell types for cancer therapy.

This is a reflection of how extremely difficult it is to understand the complex functions of a three - dimensional organism with its many different cell types and substances without animal research.

We can direct their development into different cell types by adding certain molecules to them as they divide.

As a basis for their experiments, the researchers drew on mouse studies that have identified key regulatory mechanisms acting within and between different cell types to coordinate developmental programs.

Other types of stem cells are capable of creating multiple different cell types, but not all the cell types in the body.

The group's next step is to perform new in vitro trials with different cell types to evaluate the immune response and toxicity.

These cats have two different cell types for hair colour, in which different copies of the X chromosome have been shut down.

The ultimate test of a stem cell is its ability to produce different cell types.

Researchers are trying to figure out how a plant or animal makes different cell types from the same set of genetic instructions.

The organization of these tissues let different cell types work together, to enable organs in the body to perform their functions.

Some scientists believe the ability to grow different cell types started animals on the evolutionary road to becoming humans.

In addition, during inflammation or infection different cell types must be able to pass through the vessel wall to the surrounding tissue.

However, it is becoming more and more difficult to compile a representative price survey that takes different cell types into account.

Once harvested, the stem cells can be injected and induced to grow into a large number of different cell types.

The embryos are usually four to five days old and their stem cells have the potential to develop into different cell types.

Like transcription factors, these genes turn on other stem cell genes and turn off those associated with different cell types.

16:44 - Macklis: understanding of how different cell types become neurons and how they function has improved dramatically in past 5 years

HSCs give rise to the many different cell types found in blood and can be used to treat a variety of diseases, including multiple myeloma, leukemia, and blood disorders such as sickle cell anemia.

Ficoll purified peripheral blood mononuclear cell pellets of the sort used in the current investigation are comprised of several different cell types (e.g., CD4, CD8, CD14, CD19, CD56)(Reinius et al., 2012).

He was by this time at the Sloan - Kettering Institute, New York, and had worked on different cell types to see how they released proteins into their surroundings by exocytosis.

Although these processes are affected by many different cell types within the tumour stroma, macrophages and other myeloid - derived cells are among the most important players.

Other forms of cell - cell interaction, on the other hand, are only effective in mixed population structures; these include, for example, cross-feeding mutualisms in which different cell types depend on close proximity to benefit each other [17 — 19].

Mechanical properties of many different cell types including glial cells, platelets, cardiocytes, macrophages, endothelial cells, epithelial cells, fibroblasts, bladder cells and more have been determined using F - d spectroscopy.

When several hundred members of a class of molecules called microRNAs are measured it becomes possible to distinguish different cell types including the discovery that stem cells fall into two broad categories.

Current investigations focus on how BTLA expressed by different cell types attenuates disease.

«It's amazing that nobody really knows how many different cell types there are in the human body,» said Stephen Quake, co-director of the Chan Zuckerberg BioHub.

As a single - celled organism, Capsaspora can't have multiple different cell types at the same time like humans can.

This collective of different cell types release proteins and interact, creating a «micro» environment, because of the micro scale at which these cell types co-habituate.

«To build tissues, we need to be able to take stem cells and use them to make many different cell types which are grouped together in particular spatial patterns,» explained Andres M. Bratt - Leal, the paper's first author and a former graduate student in McDevitt's lab.

The group is particularly interested in understanding how different cell types respond to defects in cell division by activation of the spindle assembly checkpoint (SAC).

Even though different cell types were used as the initial starting materials, and they were made to produce different sets of proteins, both groups identified and isolated cells nearly identical to human embryonic stem cells, and did so in the same timeframe.

(Adult stem cells, on the other hand, are much more limited in their potential; they can usually only become a few different cell types, and consequently are not applicable for treating as wide a variety of diseases as hESCs are.)

«Two completely different cell types help each other to carry one key function, to regulate the physiology of the gut,» Bogunovic said.

Plath's team found that the changes that happen in cells during reprogramming occur in a sequential stage - by - stage manner, and that importantly, the stages were the same across all the different reprogramming systems and different cell types analyzed.

During this process, the stem cells transform into the dozen or so different cell types that compose the human brain.

«This would promote different cell types developing next to each other — which would lead the way for growing micro-organs from scratch within the lab.»

In order to isolate the 3D structure of the chromosome during metaphase, the authors used a combination of chromosome conformation capture technologies (3C, 5C and Hi - C) developed by the Dekker lab over the last decade to map the points of contact along the mitotic chromosome in different cell types synchronized to divide at the same time.

Previous work from Dekker and colleagues had shown that points of interaction along the chromosome influence gene expression and are the reason why different cell types are organized differently in three dimensions.

All these very different cell types have the same ancestor, whose descendants must acquire different fates.

«The field has identified different cell types in addition to motor neurons involved in this disease, so one of our approaches was to find out what weapons these cells might be using to kill motor neurons,» Dr. Kaspar says.

«This is a major breakthrough and a beautiful example of convergent evolution where vertebrates at least five times have independently evolved» this ability «by modifying different cell types to serve the same function.»

It even uses an ordinary, off - the - shelf printhead, connected to test tubes full of different cell types instead of wells full of colored inks.

To visualize different cell types in the brain, researchers often need genetic access to that cell — the ability to express a gene of interest only in, say, chandelier cells, but not neighboring neurons.

It has billions of parts, many used to activate and silence genes — an arrangement that allows individual cells to specialize as brain cells, heart cells and some 200 other different cell types.

Previous research has shown that syncytin - 1 makes different cell types stick together.

The Cd14 protein is found among different cell types, including epithelia, blood, and dendritic cells.