Scientists devised a method to identify
different classes of compounds with the potential for eliminating senescent cells.
«The research opens up opportunities for using different reagents in nano - DESI, allowing for detailed analysis of
different classes of compounds in bewilderingly complex mixtures,» said Dr. Sergey A. Nizkorodov, an Associate Professor of chemistry at University of California, Irvine.
They created a special strain of mice that could be stripped of dopamine and injected with
different classes of compounds to try to restore movement.
Not exact matches
University
of Illinois chemist Martin Burke, a pioneer
of a technique that constructs complex molecules from simple chemical «building blocks,» led a group that found that thousands
of compounds in a
class of molecules called polyenes — many
of which have great potential as drugs — can be built simply and economically from a scant one dozen
different building blocks.
In more recent years, perovskites have expanded to a
class of compounds with a similar structure and chemical recipe — a 1:1:3 ingredient ratio — that can be tweaked with
different elements to make
different «flavors.»
Furthermore, in order to optimize the pharmacokinetic profile and to improve CXCR4 binding affinity
of this
class of molecules, dual pyrimidinyl
compounds, substituted with
different functional groups such as methoxy and morpholine, were synthesized (
compounds 194 - 200).
We developed several computational and machine learning methods to successfully identify behavioral patterns or signatures associated with
different classes of reference drugs, from which to predict the
class of novel
compounds (Brunner et al., 2012, Alexandrov et al., 2015), and more recently developed methods to allow us to compare animal models
of AD and its progression, and to identify (in silico) novel
compounds from our existing database
of thousands
of novel and reference
compounds with the potential to reverse the AD model behavioral profile.
Michelin offers five or six
different compounds to their teams, depending on the
class of car.
Danny and his peers» lives are
compounded by many
different things: the death
of a friend, anticipating changes that will occur once they all leave for college,
different family pressures and dynamics, and navigating the boundaries and intersections
of class and culture.