A new twin study sheds light on what causes reprogrammed stem cells to have
different epigenetic patterns
Obese and lean men very likely have
different epigenetic patterns in tissues throughout their bodies, he says, including sperm.
Not exact matches
A recent flurry of conferences have forwarded the idea of creating an international epigenome project that could centralize the data, set goals for
different groups, and standardize the technology for decoding
epigenetic patterns.
The Human Genome Project, which sequenced the 3 billion pairs of nucleotide bases in human DNA, was a piece of cake in comparison:
Epigenetic markers and
patterns are
different in every tissue type in the human body and also change over time.
For Helicobacter pylori, a pathogenic bacterium that colonizes over 40 percent of the world population and is associated with gastric cancer, the team discovered that
epigenetic heterogeneity can quickly emerge as a single cell divides, and
different subpopulations with distinct methylation
patterns have distinct gene expressions
patterns.
The specific
pattern of
epigenetic marks in a cell type specifies identity and this
epigenetic control is vital to what makes our cells
different, for example a skin cell from a liver cell, when they all contain the same genetic instructions.
However,
different kinds of cells have
different epigenetics, so their expression
patterns are
different.»
The program works by looking for specific molecular
patterns in cancer DNA that is free flowing in the patients» blood and comparing the
patterns against a database of tumour
epigenetics, from
different cancer types, collated by the authors.