Pol III is pretty complicated — it is made up of 17 different subunits encoded by 17
different essential genes.
Not exact matches
This interaction is explained by divergent evolution occurring among paralogs of an
essential duplicate
gene, for which the functional copy is not located at the same locus in
different accessions.
To that end, he traces the evolutionary histories of
genes from
different organisms, in order to understand the biological forces that shape
essential DNA elements and to understand the ongoing rivalry between pathogens and their hosts.
PHENOMIN's scientists have collaborated with 17
different centers over the world to identify and decipher the function of
genes that are
essential for mammalian life.
These studies demonstrate that the two important protein complexes, condensin and cohesin, are both
essential for the assembly of the functional genome architecture, but their roles in the 3D genome organization (
gene contacts and topological domain organization) are significantly
different.