Sentences with phrase «different gene expressions»

Current research is looking closely at the interactions of different gene expressions and protein networks, within normal versus neoplastic cells.

The clones also appeared to have an effect on the gene expression of the pregnant cows themselves; on day 34, some uterus tissue showed grossly different gene expression, which could affect the placenta.

The researchers also found different gene expression patterns after the flu vaccination in younger and older people.

Figuratively speaking, different gene expression means that that in the genetic material of the three ant species, certain buttons are pressed at different levels of intensity — yet, ultimately, this leads to the same result in all species: a successful raid.

Each life stage may have a different phenotype (different gene expression and function) than the other stages.»

Back in 2011, for example, her lab demonstrated that beta cells in newborn rats are immature cells with very different gene expression and function than adult beta cells.

«This suggests that two different gene expression programs may exist; one for normal cellular activity and one for regeneration,» explains Stewart.

It overlaps somewhat with recent «atlas» type papers from Tripathi and Lemaitre, but has unique aspects and different gene expression and Gal4 databases, so it will serve to complement these other studies.

Not exact matches

The resulting transcriptional profiles cluster not by postpartum day, but by milk Na: K ratio, indicating that women sampled during similar postpartum time frames could be at markedly different stages of gene expression.

Even more striking, the gene - expression pattern in the hippocampi of THC - treated aged mice was radically different from that of untreated elderly mice.

«Human and chimpanzee genes differ very little, so one hypothesis in evolutionary genomics holds that humans and chimpanzees are so phenotypically different because of differences in the way they regulate gene expression.

In his second semester, he started doing research in three different labs, including that of Carolyn Decker, a molecular biologist who was investigating how the cell controls gene expression through the destruction of messenger RNA.

Molecular characterization of the cells that undergo cell fate transition upon oncogenic Pik3ca expression demonstrated a profound oncogene - induced reprogramming of these newly formed cells and identified gene expression signatures, characteristic of the different cell fate switches, which was predictive of the cancer cell of origin, tumour type and clinical outcomes in women with breast cancers.

«We were starting to understand a lot about circuits and cells, and we had the tools to look at gene expression in different kinds of cells?

The researchers discovered that both major living lineages of birds (the common neognaths and the rarer paleognaths) differ from the major lineages of non-bird reptiles (crocodiles, turtles, and lizards) and from mammals in having a unique, median gene expression zone of two different facial development genes early in embryonic development.

The authors defined the gene signature of the different regions surrounding the wound to uncover the gene expression signature of the cells that actively divide and those that migrate to repair the wound.

Gene expression is the process whereby the genetic information of DNA is used to manufacture functional products, such as proteins, which have numerous different functions in living organisms.

This system plays a major role in the regulation of gene activity, and enables the selective expression of different functions in differentiated cell types.

The researchers have compared various processes involved in gene expression, such as gene transcription and chromatin modification, and have repeated this in different tissues and cell types from both humans and mice.

Once the pattern of expression of these genes had been identified, Prof. Khatri and his colleagues tested it out on the remaining 900 samples from patients with different tropical diseases and from healthy people.

Transcription factors are responsible for either inhibiting or promoting the expression of genes, and master regulatory transcription factors are like transcription factors on steroids: their actions regulate thousands of genes in different kinds of cells.

«Professor Hummon and I have been mapping gene expressions for the right versus the left side of the colon, which we now know are different from each other due to the way the colon forms,» said Buechler.

The genome - wide epigenetic changes clustered in certain chromatin domains and controlled «gene expression changes that specify different malignant traits, including the ability to form tumors,» McDonald said.

They found that gene expression is different at 209 sites in chronically lonely people and that many of those changes fit a pattern of elevated immune activation, inflammation, and depressed response to infection.

Previous work from Dekker and colleagues had shown that points of interaction along the chromosome influence gene expression and are the reason why different cell types are organized differently in three dimensions.

The expression of all human genes was analyzed in these tumors and correlated with different clinical parameters.

That protein, called NRSF, blocks the expression of 64 different genes and prevents them from turning a cell into a neuron.

Until now, the data and test results for this ongoing work have all come from preexisting, online digital data sets of gene expression from patients with different kinds of infections — not from current patients.

To develop a comprehensive view of astrocyte gene expression, the duo used the technique in four very different areas of the mouse brain: two regions of the cortex and the hypothalamus and cerebellum.

«Signaling pathways and gene expression profiles are very different in cells that grow in 2D and 3D cultures,» says Oksana Sirenko, a research scientist at Molecular Devices in Sunnyvale, California.

The two samples are each labelled with a different colour fluor so that the relative expression of each gene can be determined for each sample.

For mosquito transmission to occur, the sexual form gametocytes, which are structurally distinct and have a very different program of gene and protein expression, have to form continually in the blood on a 2 - day cycle.

That exposes DNA to different proteins, thereby dampening gene expression; in this particular case, that disrupts proper cell division.

For Helicobacter pylori, a pathogenic bacterium that colonizes over 40 percent of the world population and is associated with gastric cancer, the team discovered that epigenetic heterogeneity can quickly emerge as a single cell divides, and different subpopulations with distinct methylation patterns have distinct gene expressions patterns.

While previous investigations into the protein's effects have used either mice in which gene expression was knocked out or transgenic animals that expressed human gene variants throughout their lifetimes, the MGH - MIND - led study used a different approach to investigate the effects of introducing the variant forms of the protein into brains in which plaque formation had already begun.

A necklace of early stage developing wings, each labeled fluorescently to reveal a different pattern of gene expression.

Prof Tony Green, an author from the Wellcome Trust - MRC Stem Cell Institute and Cambridge University, said: «The SC3 tool was able to use patterns of gene expression to distinguish, within an individual cancer, subclones that carried different mutations.

Our work shows an exciting new way that eRNAs produce these different patterns of gene expression.

But the researchers found no significant changes in the expression of genes known to be involved in calcification from prior studies comparing strains with dramatically different calcification levels.

It plays an important role in how cells sense their neighbors and, by controlling gene expression, determines which cells should develop into different types and how much they should grow - like a master controller.»

Understanding the best ways to work with RNA and the various RNA detection methods can help scientists advance our understanding of gene expression patterns and elucidate the roles of different genomic elements in cellular function and dysfunction.

They next analyzed long gene expression in mice of different ages.

After 3 months, the researchers drew blood samples from the monkeys, purified five different types of immune cells, and measured gene expression across their entire genomes.

The researchers in the Greenberg lab found that across all analyzed datasets, and in studies of different mouse brain regions, in the absence of MECP2 the expression of long genes is increased.

In a 2015 study of 46 people, Bearden found that people with 22q11.2 deletion syndrome who have autism show different patterns of gene expression than do those with the syndrome who have schizophrenia3.

This same feature, tumor heterogeneity, may reduce the ability to identify critical gene expression changes when comparing mean gene expression in adjacent tumor and normal tissues, as tumors of the same type may have different sets of genes differentially expressed.

Surprisingly, they found that although the patterns of gene expression — as shown by the RNA sequencing — differed between the hepatocellular carcinomas and the liver cancers with biliary phenotype and depended on the histological type, the overall pattern of mutations in the cells was actually similar between the tumors — of either type — that had emerged in patients who had had infections with either hepatitis C or B, and were different in patients without such infections.

But brain cells that had been created using the direct conversion technique had different patterns of gene expression depending on whether they were created from young donors or older adults.

They built a new software tool called MIxT (Matched Interactions across Tissues) that uses computational and statistical methods to find and investigate links between gene expression in different body tissues.

«This is because while both cell types show hydroxyurea - induced gene expression, collision with replication occurs differentially because replication forks have progressed to different extent in these cells,» said Feng.