Not exact matches
The goal is to identify the
genes necessary to install C4 photosynthesis in rice through
different approaches, including genomic and transcriptional
sequence comparisons and mutant screening.
In fact, the MESA researchers had included 46
different variants of the
gene in their
sequencing database.
Bernard Friedenson, associate professor of biochemistry and molecular genetics at UIC, looked at the DNA
sequences of breast cancers from 21
different women and found mutations in
genes involved in immunity in every one of them.
I remember looking at the report and realizing that there were all of these similar
genes in all of these
different animals and thinking: «Maybe a careful reading of the papers associated with the
sequences most similar to mine will tell me something about my own
gene.»
In this standard view, the genetic differences between any two individuals are due to slight differences in the
sequence of their
genes that mean that the
genes «spell out» slightly
different proteins.
A Canadian project called FORGE (finding of rare disease
genes) aims to
sequence children and families with 200
different disorders this year.
The two proteins have
different biochemical properties and recognize
different DNA
sequences, so these properties create more options for
gene - editing,» said Dr. Olson, who holds the Pogue Distinguished Chair in Research on Cardiac Birth Defects, the Robert A. Welch Distinguished Chair in Science, and the Annie and Willie Nelson Professorship in Stem Cell Research.
However, when the
sequence of that genome emerged it appeared that the scientists were seeing double — the organism seemed to have two very
different versions of many of its
genes.
The pilot project tested a dozen or so of the most commonly used
gene promoters (regions of DNA that facilitate
gene transcription) and segments of DNA that encode ribosome - binding sites (
sequences of messenger RNA that control protein translation) to determine whether they behave consistently in
different cellular contexts.
Collaboratively, the research team
sequenced the DNA that encodes the
genes as well as the RNA from the insect at
different developmental stages, to identify when
different genes are expressed and in which tissues and organs.
Molecular geneticists dream of having a similarly comprehensive view of networks that control
genes: For example, they would like to identify rules explaining how a single DNA
sequence can express
different proteins, or varying amounts of protein, in
different circumstances (see p. 80).
By comparing proteomic and RNA -
sequencing data from people on
different exercise programs, the researchers found evidence that exercise encourages the cell to make more RNA copies of
genes coding for mitochondrial proteins and proteins responsible for muscle growth.
Because the genome for Dictyostelium has been
sequenced, researchers are already deeply immersed in teasing apart
different genes and traits that might help explain the differences between farmers and nonfarmers and how the symbiosis might have evolved in the first place.
The researchers carried out fine - scale mapping, looking for parts of the DNA
sequence that were specifically
different in butterflies with
different patterns, in three
different Heliconius species, and in each case the cortex
gene was found to be responsible for this adaptation in their patterning.
To his surprise, Lo found four
different MLV - related
gene sequences in 32 of the 37 patient samples.
They
sequenced pythons in these three states and identified 1,700
genes that were significantly
different pre - and post-feeding.
People with
different DNA
sequences in the
gene producing the OR7D4 receptor respond differently to this smell — some people find it foul, some sweet, and others can not smell it at all.
Like Wray, the scientists estimated the
genes» rate of evolution by comparing their DNA
sequences in two
different species, a technique calibrated to the date when the two species are known to have diverged.
All the plant groups the researchers examined, except liverworts, contained at least one of three distinct introns — useless chunks of DNA located inside the coding
sequence of a
gene — in two
different genes.
The BBSRC - funded ARK - Genomics facility — which is part of Edinburgh Genomics at the University of Edinburgh — provided a substantial body of
sequence data, including information on which
genes are expressed in a spectrum of 40
different tissues.
Different versions of
genes can vary at single points in their
sequence, and these variations are called SNPs.
Both Antarctic and Arctic fish carry antifreeze proteins in their blood, but the
genes that code for them not only differ in
sequence but arose at
different times, since the North Atlantic froze only 2.5 million years ago and the Southern Ocean 10 to 14 million years ago.
Previous work had shown that two variations in the COX - 2
gene, with either a guanine (G) or a cytosine (C) molecule at a particular spot in the
gene's DNA
sequence, lead to
different levels of COX - 2 protein.
They also showed that they could block up to five
genes at once by delivering
different RNA
sequences.
Between
different species, there are regions of the
gene that vary in
sequence.
The readability of
genes is controlled by epigenetic factors, namely factors which do not influence the
gene sequence directly, but rather cause certain
genes and chromosomal segments to be packed in
different densities — and thus make them accessible for reading.
As a result of having such a high concentration of movable
gene sequences,
different strains of corn are hugely
different genetically — more than one would predict.
In the last four years scientists have cloned and
sequenced many
genes carrying defects that cause disease, including those responsible for Fragile X linked mental retardation,
different forms of muscular dystrophy, and most recently Huntington's disease.
And when they
sequenced Sputnik's genome, they found its small ring of DNA contained
genes from three
different viral families, including Mamavirus.
Surprisingly, they found that although the patterns of
gene expression — as shown by the RNA
sequencing — differed between the hepatocellular carcinomas and the liver cancers with biliary phenotype and depended on the histological type, the overall pattern of mutations in the cells was actually similar between the tumors — of either type — that had emerged in patients who had had infections with either hepatitis C or B, and were
different in patients without such infections.
To do this, they incorporated the
gene sequence of each receptor into cultured cells and then probed the cells to determine if they were activated by one or more of 25
different bitter - tasting chemicals.
GenProfile focuses on the systematic analysis of DNA
sequence variation in biomedically relevant
genes in order to identify those variants, or combinations of variants (
gene profiles), that determine an individual's genetic risk for disease, predict individually
different drug response, and ultimately pave the way to a personalized medicine.
Then they determine the
sequence of as many of those
genes as their grant money will allow — typically around a thousand, coming from a thousand bacterial cells — and use that information to estimate how many
different kinds of bacteria are present in the sample.
Because
genes on the Y chromosome often vary slightly in
sequence — and even function — from the corresponding
genes on the X, males could have slightly
different patterns of
gene expression throughout the body compared with females, due to not only their hormone levels, but also their entire Y chromosome.
If the
gene sequences were very
different, he would know they diverged a long time ago because they had evolved away from each other — simple, logical, objective.
By focusing on several of these mutations and screening through guide RNA variants with
different mismatch combinations, they were able to identify specific guide RNAs that stimulated Cas9 activity towards the mutated
gene sequences but left the normal counterpart untouched.
Natural
gene sequences have been shaped in response to many
different evolutionary pressures, but are rarely optimal for aspects of «biotechnological fitness,» such as maximized protein yield or optimal expression control.
They're continuing to
sequence prostate tumors to learn how frequently
different mutations occur, as well as studying which of the rearranged
genes are actually driving cancer.
The transmission of
different states of
gene expression through multiple cell divisions and across generations has been termed «epigenetic,» since the underlying DNA
sequence is identical in both states.
The case highlights concerns that a network of individual
gene patents could threaten the future of personalized medicine and whole - genome
sequencing by blocking companies and clinicians from reporting a patient's genetic risk factors for
different diseases.
Analysis of the DNA and encoded amino acid
sequences of A14 and B9 revealed that the first two are clonal variants which aligned most closely to the germ line denoted VHH Vg (T Verrips, unpublished data) and that the
sequence of B21 is highly divergent from both and also aligns to a
different germ line V
gene sequence Vu.
Use existing GenBank
sequences to compare cladograms of the same plants with
different gene inputs.
Finding the
genes responsible for the increased risk is not straightforward because small
sequences of DNA can interact with completely
different parts of the genome through a strange phenomenon known as «DNA looping».
Remember that a
gene is a set of instructions, spelled using the chemical «letters» A, C, G and T. Each
gene has a
different sequence of letters, and cells use zinc - containing proteins to help control individual
genes based on their specific
sequence of letters.
Once the cells were color - coded, Cembrowski could work with the Quantitative Genomics team to get
sequencing data and he found that the green and magenta cells»
gene expression was strikingly
different.
«We now have an immense amount of
gene sequencing information for a number of
different diseases,» said Krogan.
That's a
gene with a slightly
different DNA
sequence — or genetic blueprint — from most others of its species.
They used a method to identify
genes that are co-expressed with already known endothelial - enriched
genes and analysed RNA
sequencing data from 124 unprocessed tissue samples from 32
different organs.
With the
sequence data in hand, the scientists were able to categorize the
genes into three groups, each modified by
different combinations of the two epigenetic markers.
Many million
different users consult these databases each year, seeking information on anything from DNA
sequences, protein structures,
gene expression profiles, human genetic polymorphism or even comparative analyses of entire genomes.