To study this mystery, Chen's team developed a new computational method to define where
different glioblastoma subtypes develop in the brain.
Not exact matches
Identifying the drivers of these
different cellular states in
glioblastoma stem cells could offer us the best opportunity for treating what remains an extremely difficult - to - treat tumor.»
From tissue and cell samples from five
glioblastoma patients, the scientists obtained 33 individual cancer cells capable of reproduction, which grew into very
different tumors in the lab.
Shah next plans to rationally combine the toxin - secreting stem cells with a number of
different therapeutic stem cells developed by his team to further enhance their positive results in mouse models of
glioblastoma, the most common brain tumor in human adults.
Researchers at University of California San Diego School of Medicine have demonstrated that distinct types of
glioblastoma, the most common form of brain cancer in adults, tend to develop in
different regions of the brain.
The activation of this signaling pathway progressively increased in
different types of gliomas, with the highest activity seen in patients with
glioblastoma, a particularly difficult - to - treat form of brain cancer that represents approximately 15 percent of all brain tumors.
The NYGC and its founding member institutions are conducting additional studies involving Watson to help accelerate the discovery of potentially actionable sequence variants in various types of cancer, including an ongoing study that involves DNA and RNA from a larger cohort of
glioblastoma patients, and a study of 200 patients with
different types of cancer.
Newswise — Researchers at University of California San Diego School of Medicine have demonstrated that distinct types of
glioblastoma, the most common form of brain cancer in adults, tend to develop in
different regions of the brain.
It may help classify patients with very high accuracy into the
different existing
glioblastoma subtypes, which differ in survival and treatment response.
Many if not all
glioblastoma cells have a
different genetic makeup, making it impossible to find one common mutation or target for treatments.
Professor Susan Short, member of NCRI's Radiotherapy Research Working Group, said: «We're just beginning to realise the full potential of PARP inhibitors to tackle many
different types of cancer, so it's exciting to see that olaparib could potentially be used to treat
glioblastoma in combination with chemotherapy and radiotherapy.