In view of the
different timing of meiotic initiation in female and male mammals, we determined the developmental expression profile of mouse Boule during both male and female embryonic
gonadal development (embryonic day 10.5, E12.5, E16.5 and E17.5) in comparison with adult gonads.
While the study set out to estimate incidence rates of each disease related to age at neutering, patients were diagnosed at
different ages and with differing durations of the disease as well as varying years at risk from the effects of
gonadal hormone removal.