Sentences with phrase «different immune mechanisms»

We investigated the relative importance of different immune mechanisms in limiting the spread of the intestinal microbiota.

A different immune mechanism, the innate immune response, comes into play in reactions of gluten sensitivity, as opposed to the long - term adaptive immune response that arises in celiac disease.

Not exact matches

The three main conditions — celiac disease, gluten sensitivity, wheat allergy — are based on very different mechanisms in the immune system.

Different studies suggest that bacteria present in the maternal gut could reach the mammary gland during late pregnancy and lactation through a mechanism involving gut immune cells.

It also may have helped several others by boosting the power of a new type of cancer drug that uses a different mechanism to unleash an immune attack on the tumor.

Our experts in mucosal vaccine delivery have established in vitro and in vivo models to assess the activity of adjuvants and vaccine formulations on innate and adaptive immune cells, as well their capacity to stimulate different effector mechanisms of clearance.

The other major class of immunotherapies are known as anti-CTLA-4 treatments, such as ipilimumab (Yervoy), which target a different mechanism to unleash immune cells to fight tumors.

She is registred to the National Order of Biologists in the province of Palermo; collaboration in research project from 2012 to 2015 at the Department of Biopathology and Biotechnology, University of Palermo, focusing the study on the identification of molecules capable to modulate intracellular metabolic pathways for the prevention and treatment of infectious, tumor and degenerative disease, in collaboration with Prof. Angela Santoni, University of Rome; collaboration in research project in 2011 at the hospital «Villa Sofia Cervello» of Palermo to study methods can cure the genetic defect that causes thalassemia through genetic engineering; she studies different mechanisms of the differentiation and the activation of human gammadelta T cells as effector cells of the immune response against cancer and infectious diseases; she investigates about the identification and development of biomarkers of resistance and susceptibility to Mycobacterium tuberculosis infection; Valentina Orlando has published 13 papers in peer reviewed journals and 3 comunications at national and international congress.

The first of its kind, the study provided specific markers to distinguish different disease states in asthma and paved the way for investigating the role of epigenetic mechanisms in other immune - mediated disorders and infectious diseases.

Research Focus: I dedicate my time and effort to develop high - throughput sequencing technologies such as single cell transcriptomic, ChIP - Seq, ChIA - PET, and many more... The scientific rational is to understand better and with a different angle, the mechanisms of epigenetic regulation of gene expression in (rare) immune cells, pathologically relevant in many diseases such as asthma, SLE, tuberculosis...

Therefore the group studies with sophisticated imaging technology in vitro and ex vivo: i) the molecular mechanism driving the migration of HIV through the intestinal epithelial barrier; ii) the cellular targets in the mucosa, in specific macrophages and DCs, to identify the possible pathways to invade the tissue and disseminate to other organs; iii) the involvement of DCs and their functional properties in mediating adaptive immune responses at mucosal level; and iv) the role of antibodies with different effector functions in changing the pathways of the virus.

- Conclusion: The anti-gliadin (gluten) immune response in autism involves a mechanism that is different from celiac disease.

During last decades different models such as molecular mimicry, «bystander effect» and viral persistence were proposed as possible mechanisms that initiate the overreaction of the immune system and lead to an autoimmune disease.

Alpha Herpesviruses such as FHV - 1 cause disease by two distinctly different mechanisms: 1) cytolytic (cell - rupturing) disease which involves active viral replication and destroys the epithelial cells of the cornea and conjunctiva causing ulceration; and, 2) immune - mediated disease results from the deposition of viral antigen in subepithelial tissues.