While metastatic sites may have originated from the primary tumor, several studies have demonstrated
a different immunohistochemical or mutation profile compared to the primary.
Not exact matches
Immunohistochemical demonstration of Cyclin D1 have become an important mean for assessing cell proliferation, therefore the immunohistological demonstration of cell cycle related antigens such as CDKs which regulated by the
different cyclins could provide a good tool for assessment of cellular proliferation [11].
Tissue microarrays are used to show antibody staining in samples from 144 individuals corresponding to 44
different normal tissue types, and samples from 216 cancer patients corresponding to 20
different types of cancer (movie about tissue microarray production and
immunohistochemical staining).
For independent antibodies, the
immunohistochemical data from all the
different antibodies are taken into consideration.
MCF7, 231, and 468 lines and an ER - α — positive metastatic sample (COB) were implanted subcutaneously into mice, and xenografts were harvested at
different time points; half was embedded in paraffin for
immunohistochemical analysis, whereas half was dissociated for mammosphere culture.