It's a different genetic situation, a different lifestyle,
a different microbiome.
Scientists attribute this heft to
different microbiomes — the communities... Read More
The experiment at the University of Oregon was designed to test, at a fundamental level, the impact of microbial dispersal among individuals with
different microbiomes.
Scientists attribute this heft to
different microbiomes — the communities of microorganisms that live in and on the body — in the C - section group.
The offspring that died had very
different microbiomes to their parents» in terms of the proportions of the various types of bacteria.
In support of this theory, my lab discovered that the Khoisan, a traditional hunter - gatherer population from Southern Africa, have dramatically
different microbiomes than found in industrialized societies.
And a recent study showed that patients with Parkinson's disease have
different microbiomes than matched controls.
Not exact matches
In addition, many studies do not take into account the complex interaction of
different fatty acid subtypes, such as omega - 3 and omega - 6 fatty acids, on gut inflammation as well as their effect on the intestinal
microbiome.
They also showed that the gut
microbiome of a healthy person looks very
different to that of someone with a bowel condition like Crohn's disease or ulcerative colitis.
In a thorough survey of our skin
microbiome, Elizabeth Grice identified species from at least 205
different genera.
They compared fecal samples, loaded with gut
microbiome members, from three groups: Amazonian hunter - gatherers and Andean farmers, both living in Peru, and an industrialized population in the U.S.. Each group possessed distinct
microbiomes with varying types of bacteria, but the American population stood out for having both
different and less diverse critters.
While the study looked only at the ability of fish to exchange microbes, it suggests that
microbiome variation among
different people might also be due to the movement of microbes, and that when people come together for a class or a meeting, for example, they may depart with a
microbiome that is somewhat
different than when they entered, Bohannan said.
The Wyss team believes the ability of the human gut - on - a-chip to culture the
microbiome with human gut cells also holds promise for the field of precision medicine, where a patient's own cells and gut microbiota could one day be cultured inside a gut - on - a-chip for testing
different therapies and identifying an individualized treatment strategy.
«This technology enables one to study in an isolated and controlled manner the complexity of the
microbiome and the role
different microbial species play in health and disease.
«We found that the
microbiome changes as the queen matures, but the
microbiomes of
different queens are very similar — regardless of the environment each queen is in,» says Dr. David Tarpy, a professor of entomology at NC State and co-author of a paper describing the work.
For example, when they tested the gut
microbiome from a healthy human male the old way, they found 127
different species.
The gut bacteria from the wild mice were fairly similar, but the
microbiomes of the lab mice were significantly
different, with fewer Bacteroidetes and Proteobacteria, for example.
Both projects found that each person's body supports many
different microbial ecosystems, and that our
microbiomes vary greatly from person to person.
«The
microbiome of a dust storm originating in the Sahara is
different from one blowing in from the Saudi or Syrian deserts, and we can see the fit between the bacterial population and the environmental conditions existing in each area.»
After each bout, though, the samples told a
different story: the teams»
microbiomes converged, having more species in common.
Since the bacteria are associated with contributing to good health, Mangalam and his colleagues wondered whether those with a chronic autoimmune disorder, such as multiple sclerosis, would then have a gut
microbiome that is
different than the
microbiome found in healthy individuals.
Mice in the study that were put on a rich diet and received
microbiome transplants helped the Wisconsin team expose functional differences attributable to two
different transplanted
microbiomes, including a link between the gut
microbiome and insulin secretion.
They also pre-treated one cohort of mice with antibiotics, to determine if that pretreatment resulted in
different shifts in the
microbiome as compared to those in mice not receiving antibiotics (it did so).
Angenent explains the process: «We kept two
microbiomes under
different temperatures and placed them in series.
He used a tank with many
different types of bacteria, called a reactor
microbiome.
Across several
different zoos on three
different continents, all captive primate
microbiomes showed the same pattern of converging toward the modern human
microbiome.
«The new study demonstrates that divergence of humans from great apes was accompanied by the establishment of a completely
different, human - specific
microbiome,» says Bosch.
In a study appearing in the journal PLOS ONE, researchers at The Ohio State University and their colleagues have demonstrated how two separate effects of climate change combine to destabilize
different populations of coral microbes — that is, unbalance the natural coral «
microbiome» — opening the door for bad bacteria to overpopulate corals» mucus and their bodies as a whole.
Michael Blaut, a microbiologist at the German Institute of Human Nutrition in Potsdam, Germany, says the mouse data are «believable and remarkable,» but says he has a hard time imagining a mechanism that would account for three compounds as chemically
different as aspartame, saccharin, and sucralose leading to the same changes in the gut
microbiome.
The gut
microbiome is the population of microbes living within the human intestine, consisting of tens of trillions of microorganisms (including at least 1,000
different species of known bacteria).
Next up: Getting stool samples at
different times of the year, not just summer, to see how the
microbiomes variy as people's diets change over the seasons.
The finding raises the question of whether the
microbiome may help explain the
different protective effects of oral PrEP, a preventative HIV procedure, in men and women.
The researchers suggest that living in a rural or urban environment may change the intestinal
microbiome, due to
different exposures early in life, resulting in decreased or increased risk
They emphasize that clinical assessments of
different fiber types and fiber - enriched foods on
microbiome outcomes are needed.
With crowdfunded projects such as American Gut, which already has thousands of participants who have had their
microbiomes sequenced, and studies of people whose lives are very
different from modern Western civilization, such as the Hadza of Tanzania, Yanomami of Venezuela and Matsés of Peru, we may be able to replenish our ancestral microbes and discover new ones that help to maintain health for individuals or entire populations.
So what is
different this time with the
microbiome?
In this case, the parts are the host and its genome plus the thousands of
different species of bacteria living in or on the host, along with all their genomes, collectively known as the
microbiome.
These catalogs provide a baseline for understanding how
microbiomes change over time — in health and disease — and how
microbiomes respond to
different factors such as diet and climate.
Today, the White House Office of Science and Technology Policy (OSTP), in collaboration with Federal agencies and private - sector stakeholders, is announcing a new National
Microbiome Initiative (NMI) to foster the integrated study of
microbiomes across
different ecosystems, and is hosting an event to bring together stakeholders vital to advancing the NMI.
«Our goal is to discover what microbial communities exist in
different parts of the human body and to explore how these communities change in the presence of health or disease,» said National Human Genome Research Institute Director, Francis S. Collins, M.D., Ph.D., co-chair of the Human
Microbiome Project Implementation Group.
Next, they were given one of two types of antibiotics commonly used in medicine, one that is absorbed into the bloodstream and one that is not, each of which had a
different effect on the
microbiome.
Public - private initiative aims foster the integrated study of
microbiomes across
different ecosystems.
Maybe one day when we know more about the
microbiome in the human gut, scientists could develop a computer program to predict how the
different types of food we eat, or antibiotics we take, affect the gut
microbiome.
Through this «omics approach we will also investigate the viral vaginal
microbiome population, potentially identifying additional viral contributors associated with
different HPV subtypes.
Can one get a similar behavioural change by changing the gut
microbiome of a normal mouse (
different to the germ - free mice that the authors used)?
In the roundtable, they discussed the importance of the
microbiome, the necessity for collaboration across
different fields of science, and where they hope the science is leading.
They discovered that giving the mice antibiotics produced very
different effects on their gut
microbiomes, as well as on their insulin sensitivity, tissue inflammation and related metabolic functions such as blood glucose, depending on the genetic background of the mouse.
Still, we can study
microbiomes in
different contexts.
Applications are invited from individual scientists as well as collaborative teams, but emphasis will be placed on Ideas that are cross-disciplinary and leverage the expertise of
different research disciplines in generating tools and methods that address compelling
microbiome research needs using innovative technical approaches.
The study is the result of one the first collaborations from the
Microbiome Center, a joint effort by the University of Chicago, the Marine Biological Laboratory and Argonne National Laboratory to support scientists at all three institutions who are developing new applications and tools to understand and harness the capabilities of microbial systems across
different fields.