Dr. Lui examined the effect of a whole ginger extract containing 5 % gingerol on a number of
different ovarian cancer cells..
Not exact matches
The researchers then used a combination of existing United States Food and Drug Administration - approved drugs to target autophagy and found
ovarian cancer cells to be highly sensitive to these drugs in several
different mouse
cancer models — even among
cells resistant to standard chemotherapy.
The study published in
Cancer Cell shows that exosomes from tumor cells of breast cancer (and other tumor types such as ovarian and endometrial) are different in size and composition than those of healthy
Cancer Cell shows that exosomes from tumor
cells of breast
cancer (and other tumor types such as ovarian and endometrial) are different in size and composition than those of healthy
cancer (and other tumor types such as
ovarian and endometrial) are
different in size and composition than those of healthy
cells.
The researchers then exposed
cells from each of these lines to a panel of 31
different drug treatments — including 23 chemotherapy compounds approved by the FDA for breast and
ovarian cancers, six targeted
cancer drugs, and two common drug combinations.
The resulting «map» of gene - drug interactions allowed the researchers to accurately predict the responses of multiple human
cancer cell lines to
different chemotherapy agents based on the
cell lines» genetic profiles and also revealed new genetic factors that appear to determine the response of breast and
ovarian tumor
cells to common classes of chemotherapy treatment.
The authors studied a standard panel of 60 established human tumor
cell lines representing nine
different human
cancers, as well as several specimens of human primary
ovarian cancer.
In the experiments described in the paper, the MGH team confirmed that their mesothelin - targeting fusion protein binds to mesothelin on either
ovarian cancer or mesothelioma
cells, activates dendritic
cells, and enhances the
cells» processing and presentation of several
different tumor antigens, inducing a number of T -
cell - based immune responses.