Sentences with phrase «different populations of cells»

This suggests that our automatic screening assay is specifically measuring the effect amiodarone HCL has on different populations of cells.

The players are the healthy cells, the targeted cancer cells and the resistant cancer cells and the game is played over and over again in the computer simulation as the different populations of cells compete.

A single tumor is composed of many different populations of cells.

Tumors, for example, are known to contain different populations of cells, some of which are quite different to each other in their genetic makeup.

Not exact matches

Although the new JNCI study did not analyze individual cell phone usage — preferring instead to take a broader look at the population at large — other research has examined subgroups of cell phone users to try to discern different trends among more frequent use.

Now, a team of scientists at the Icahn School of Medicine at Mount Sinai have developed the Just EGFP Death - Inducing T - cell, or JEDI T - cells, which enable the visualization of T - cell antigens, allowing researchers to study T - cell interactions with different cell types, model disease states, and finally determine the functions of otherwise poorly characterized cell populations.

Human epidermal equivalents representing different types of skin could also be grown, depending on the source of the stem cells used, and could thus be tailored to study a range of skin conditions and sensitivities in different populations.»

Next, they used a technique called fluorescence - activated cell sorting to separate out the newly differentiated retinal ganglion cells from a mixture of different cells into a highly purified cell population for study.

Researchers in this study used budding yeast, creating populations of cells with more than 10 million different randomised genomes, to investigate how genetic diversity affected resistance.

For Helicobacter pylori, a pathogenic bacterium that colonizes over 40 percent of the world population and is associated with gastric cancer, the team discovered that epigenetic heterogeneity can quickly emerge as a single cell divides, and different subpopulations with distinct methylation patterns have distinct gene expressions patterns.

In this mouse model, mutations in Kras and p53 genes resulted in the formation of individual tumor cell populations that were labeled with different colors.

Stem cell populations reside in areas called niches deep within different types of organs.

The code that a monkey's brain uses to represent faces relies not on groups of nerve cells tuned to specific faces — as has been previously proposed — but on a population of about 200 cells that code for different sets of facial characteristics.

In addition, they also counted the numbers of various types of single - celled organisms called testate amoebae, whose population changes depending on the amount of water in the bog, giving an indication of how wet or dry the climate was during different periods.

In the different cell types, the loops begin and end at different specific chromosomal locations, so each cell line's genome appears to have a unique population of loops.

Their recent study, which appears as the cover article in the May issue of Cancer Research, shows that mathematical models can be used to predict how different tumor cell populations interact with each other and respond to a changing environment.

To look at the effects of heat shock on native populations of proteins, Drummond and his colleagues utilized a novel set of techniques that allowed them to simultaneously track almost 1,000 different mature proteins in yeast cells.

In principle, tissue banks of parthenogenetic cell lines could include enough different immune protein combinations to treat up to half of the U.S. population — men as well as women — Lanza says.

The researchers tested the drug on mice with H. pylori infections from several different cell lines, and found that the drug was effective against the H. pylori while maintaining populations of healthy gut bacteria.

Researchers at the Institute for Stem Cell Therapy and Exploration of Monogenic Diseases (I - Stem — Inserm / AFM / UEVE), in collaboration with CNRS and Paris Descartes University, have recently developed a new approach to better control the differentiation of human pluripotent stem cells, and thus produce different populations of motor neurons from these cells in only 14 days.

This phenomenon, which indicates the presence of different mitochondrial DNA types in a cell or an individual, can be found in more than half of the population.

The selection strategy targeted cell populations expressing the inducible endothelial cell adhesion molecules, E-selectin and VCAM - 1, and proved successful in generating microvascular endothelial cell lines from a number of different organs.

This murine model system offers a superior source of immortalized cell populations as many of the difficulties associated with the in vitro transfection process are eliminated (e.g., initial requirement for many cells, different sites of gene integration, multiple copy number; Ref.

Researchers at the Institute for Stem Cell Therapy and Exploration of Monogenic Diseases (I - Stem — Inserm / AFM / UEVE) have recently developed a new approach to produce different populations of motor neurons from these cells in only 14 days.

Other forms of cell - cell interaction, on the other hand, are only effective in mixed population structures; these include, for example, cross-feeding mutualisms in which different cell types depend on close proximity to benefit each other [17 — 19].

The experimental plan includes a fine - grained analysis of the different cell populations within these precious tissues using cutting - edge single - cell genomics methods.

With regard to HgT, a molecular analysis of cybrid cells with identical nuclear backgrounds and different mtDNA populations indicated that HgT cybrids had a higher survival rate and were more tolerant of oxidative stress when compared to the more common European haplogroup H [45].

A major new insight is the realization that different tumors of the same type may rely on entirely different tumor stem cell populations.

Alterations accomplished using CRISPR, which enables scientists to edit a cell's DNA with unprecedented precision, are different in one crucial respect: The process can result in «gene drive,» a naturally occurring feature of some genes that enables them to spread through a population over generations, even if they do not help survival (and thus reproduction).

He is also interested in understanding the transcriptional regulation of lineage choice between different stem cell populations that occurs in the blastocyst.

We show that subpopulations of human astrocytes, generated by activation of different signaling pathways in the same population of human glial precursor cells, have markedly different effects when transplanted into the injured spinal cord.

Our findings suggest that pluripotency is determined by the capacity of a mixed population of lineage - biased intermediates to commit to different cell fates in specific contexts.

While it has been demonstrated previously that more differentiated cells demonstrate a lower reprogramming efficiency [11] and different somatic cell types possess differential reprogramming ability [12], [13], no study to date, to our knowledge, has identified subpopulations of cells within a primary cell population possessing differential reprogramming potential.

Our studies reveal the existence of two segregated excitatory synaptic microcircuits that propagate homeostatic sleep information from different populations of intrinsic MB «Kenyon cells» (KCs) to specific sleep - regulating MBONs: sleep - promoting KCs increase sleep by preferentially activating the cholinergic MBONs, while wake - promoting KCs decrease sleep by preferentially activating the glutamatergic MBONs.

It is important to distinguish lineage specific gene expression shown here, which occurs at a high level and with a degree of specificity in the different population compartments, to the low level of genome wide transcription observed in ES cells by others [22], or with transcript initiation at many loci noted previously in ES cells [23].

To confirm the finding, normal bone marrow cells were exposed to either IMGN632 or X-ADC for 72 hours at a concentration highly active against AML cells (100 pM), and the degree of caspase 3 activation, a marker of apoptosis, in different cell populations was assessed by flow cytometry (supplemental Figure 4).

Dogs are correlated with different forms of leukemia disease, i.e. acute and chronic.The size of the population of white blood cells in the bone marrow represents the acuteness of disease.