Yet there were numerous
different subclone haplotype — one came to dominate, but the others persisted as well.
Not exact matches
Prof Tony Green, an author from the Wellcome Trust - MRC Stem Cell Institute and Cambridge University, said: «The SC3 tool was able to use patterns of gene expression to distinguish, within an individual cancer,
subclones that carried
different mutations.
By labeling the
different subgroups with fluorescent dyes, researchers determined that just one of the
subclones was responsible for the disease metastasis.
We see extensive variability in genomes among tumours of
different tissue types, among
different patients within a tissue type and among
subclones within a given patient's cancer.
Cancers contain genetically
different subpopulations of cells, called
subclones.
Thus, two
subclones of the tumor in AML35 both acquired activating mutations of IDH2 at the same residue but by
different mutations.
We developed and implemented such a nomenclature for the European human pluripotent stem cell registry (hPSCreg), which needs to: 1) unambiguously identify a registered cell line; 2) allow tracing of
subclones of a particular line; and 3) enable the assignment of
different lines to a specific donor origin.