In concurrent studies, the team will examine the gene expression profile
of subsets of patients with
different clinical outcomes to provide further insight into why certain dogs have more aggressive B - CLL and to identify possible drug targetable pathways to improve the treatment for this cancer.
Possibly, mania is a more purely biologically driven phenomenon than bipolar depression, with onsets more readily attributable to medication inconsistency, sleep deprivation, circadian disruption, or behavioral activation.21,22,84 - 86 In contrast, social and familial support has been found to protect against depression in bipolar and unipolar affective disorders, but the role
of these variables in manic recurrences is unclear.86 - 88 An analysis
of laboratory interactional data from a
subset of 44 families in this sample revealed that treatment - related improvements in family communication skills were more closely associated with reductions in
patients» depressive than manic symptoms.56 Thus, manic and depressive symptoms may be influenced by
different constellations
of risk and protective factors.